<p>This study proposed a concept for evaluating biological functions by its physico-chemical properties such as surface wettability. To realize the concept, we have to prepare two elements; (1) systems for assessing the physico-chemical properties of biological objects and (2) a database connecting physico-chemical properties to biological functions. In this study, non-contact wettability assessment system was used as an apparatus for assessing surface wettability, one of the most common physico-chemical properties. Because this system can eliminate a physical contact between a probe and an object, there is an advantage on contamination reduction. Furthermore, in-liquid evaluation is feasible by the system. Therefore, this study aimed to the evaluation of cellular functions via the surface wettability on the cultivated cellular tissues.</p>