論文

査読有り
2019年8月

Tradescantia pallida extract inhibits biofilm formation in Pseudomonas aeruginosa.

Nagoya journal of medical science
  • Mariko Kamiya
  • ,
  • Takeshi Mori
  • ,
  • Mio Nomura
  • ,
  • Takayuki Inagaki
  • ,
  • Tunemasa Nonogaki
  • ,
  • Akito Nagatsu
  • ,
  • Yuka Yamagishi
  • ,
  • Hiroshige Mikamo
  • ,
  • Yoshiaki Ikeda

81
3
開始ページ
439
終了ページ
452
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18999/nagjms.81.3.439

Pseudomonas aeruginosa is capable of biofilm formation. In this study, we investigated the effects of aqueous Tradescantia pallida extract on Pseudomonas aeruginosa growth and biofilm formation. Aqueous Tradescantia pallida extracts significantly inhibited both bacterial growth and biofilm formation. However, methanolic Tradescantia pallida extracts inhibited neither. Aqueous Tradescantia pallida extracts were deactivated by heating but were not deactivated by light exposure. The ingredients retained the inhibitory effect on the bacterial growth and biofilm formation after ultrafiltration of aqueous Tradescantia pallida extract. Furthermore, polyphenol-rich Tradescantia pallida extracts inhibited bacterial growth, thus, polyphenols are possible to be an active ingredient. We observed the biofilm by scanning electron microscopy, and quantitative and qualitative differences in the biofilm and cells morphology. Interestingly, the biofilm treated aqueous Tradescantia pallida extracts remained premature. We postulated that premature biofilm formation was due to the inhibition of swarming motility. Indeed, aqueous Tradescantia pallida extracts inhibited swarming motility. These results demonstrate that Peudomonas aeruginosa growth and biofilm formation are inhibited by aqueous Tradescantia pallida extracts.

リンク情報
DOI
https://doi.org/10.18999/nagjms.81.3.439
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31579334
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728195

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