論文

査読有り
2017年11月

Induction of oxidative stress by anticancer drugs in the presence and absence of cells

ONCOLOGY LETTERS
  • Chikako Yokoyama
  • ,
  • Yuto Sueyoshi
  • ,
  • Mika Ema
  • ,
  • Yumi Mori
  • ,
  • Kazuto Takaishi
  • ,
  • Hisashi Hisatomi

14
5
開始ページ
6066
終了ページ
6070
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3892/ol.2017.6931
出版者・発行元
SPANDIDOS PUBL LTD

Reactive oxygen species (ROS) are generated in the cell through multiple mechanisms. Intracellular ROS are rapidly detoxified by various enzymatic and non-enzymatic mechanisms; however, disruption of the oxidant-antioxidant balance causes oxidative stress and elicits cell damage. The oxidative stress induced by chemotherapy is known to cause side effects in patients with cancer. However, few studies have examined whether anticancer drugs induce oxidative stress in cancer cells. Furthermore, the precise mechanism by which anticancer drugs induce the generation of ROS remains unclear. In the present study, to investigate whether anticancer drugs induce oxidative stress, DLD-1 human colorectal cancer cells were treated with 20 different anticancer drugs and then stained with CellROX (R) ROS detection reagent. Furthermore, an oxygen radical absorbance capacity assay in the presence of copper was performed to estimate the oxidative activities of the anticancer drugs in the absence of cells. The data of the present study using assay methods in the presence and absence of cells suggest that nimustine, actinomycin D, doxorubicin, mitomycin C, mitoxantrone, carmofur, gemcitabine, mercaptopurine, camptothecin, paclitaxel, vinblastine, and vinorelbine are able to induce oxidative stress.

リンク情報
DOI
https://doi.org/10.3892/ol.2017.6931
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29113247
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000415083000139&DestApp=WOS_CPL
ID情報
  • DOI : 10.3892/ol.2017.6931
  • ISSN : 1792-1074
  • eISSN : 1792-1082
  • PubMed ID : 29113247
  • Web of Science ID : WOS:000415083000139

エクスポート
BibTeX RIS