論文

査読有り 本文へのリンクあり
2019年

Improvement of detection limit of nanomechanical deflection using optical interferometry for label-free molecular detection

Sensors and Materials
  • Satoshi Maruyama
  • ,
  • Yong Joon Choi
  • ,
  • T. Kazuhiro Takahashi
  • ,
  • Kazuaki Sawada

31
9
開始ページ
2895
終了ページ
2906
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18494/SAM.2019.2247
出版者・発行元
MYU, SCIENTIFIC PUBLISHING DIVISION

© MYU K.K. Herein, we report an improved minimum detectable displacement on a surface stress biosensor using optical interferometry, allowing for the detection of a low biomarker concentration via antigen-antibody reaction. The sensor is composed of a submicron-thick freestanding polymethyl methacrylate (PMMA)/parylene-C membrane on a polydimethylsiloxane (PDMS) substrate with a microcavity to generate optical interference. The cavity structure was fabricated by transferring the submicron-thick bilayer to the highly adhesive PDMS substrate. The detection of human serum albumin antigen at a concentration of 1 pg/mL was achieved by antigen-antibody reaction using simultaneous optical and electrical measurements. In addition, the minimum detectable displacement of the optical interferometric surface stress sensor was determined to be 42.6 pm, representing an 11.7-fold improvement compared with conventional cantilever-based surface stress sensors.


リンク情報
DOI
https://doi.org/10.18494/SAM.2019.2247
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000487137200009&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072645404&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85072645404&origin=inward

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