論文

査読有り 国際誌
2021年6月20日

Needle-Type $5\ \mu\mathrm{m}$ Pixel Pitch pH-Image Sensor and Imaging of Proton Emissions in the Cerebral Cortex

2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)
  • Kotaro Sakamoto
  • Mai Madokoro
  • Hiroshi Horiuchi
  • Junko Ishida
  • Tomoko Horio
  • Yasuyuki Kimura
  • Takeshi Hizawa
  • Yong-Joon Choi
  • Kazuhiro Takahashi
  • Toshihiko Noda
  • Junichi Nabekura
  • Kazuaki Sawada
  • 全て表示

開始ページ
271
終了ページ
274
記述言語
英語
掲載種別
研究論文(国際会議プロシーディングス)
DOI
10.1109/transducers50396.2021.9495573
出版者・発行元
IEEE

We developed a 256 x 32-pixel needle-type pH image sensor to visualize ion behavior at the cellular level under in vivo conditions. This sensor has a pixel configuration that can be fabricated via a modified CMOS process technology, and it achieved a pixel size of 5.65 x 4.39 mu m(2). The proposed image sensor is the highest-definition implantable ion image sensor among other conventional image sensors. For in vivo implantation, the sensor's shape was modified to a needle structure of 9.88 x 1.10 mm(2) with a thickness of 100 lam. From the measurement results, we verified that the sensor exhibits a high spatiotemporal resolution with a pH sensitivity, pH resolution, and temporal resolution of 56.4 mV/pH, 0.015 pH, and 14.1 fps, respectively. In addition, we detected pH changes in the brain of the experimented mouse during neural hyperexcitation, and successfully reproduced the measured data as 2-D images in real time.

リンク情報
DOI
https://doi.org/10.1109/transducers50396.2021.9495573
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000707041600072&DestApp=WOS_CPL
URL
http://xplorestaging.ieee.org/ielx7/9495312/9495375/09495573.pdf?arnumber=9495573
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85114964219&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85114964219&origin=inward
ID情報
  • DOI : 10.1109/transducers50396.2021.9495573
  • ISSN : 2167-0013
  • eISSN : 2167-0021
  • ISBN : 9781665412674
  • SCOPUS ID : 85114964219
  • Web of Science ID : WOS:000707041600072

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