<p>Focusing on a strength reduction factor related to door openings provided in AIJ standards in 2010, a series of experimental studies was performed with multi-story shear wall specimens with different configurations of door openings. In this study, besides the former specimen with eccentricallyaligned door openings, two specimens were designed to fail between the door openings. The observed strengths of all specimens agreed well with the values predicted using the index proposed by the authors' previous study. Furthermore, a specimen with shear margin of 1.2 obtained using the proposed index was tested, and its effectiveness for the assurance design was verified.</p>