論文

査読有り 国際誌
2020年6月

Plasma levels of matrix metalloproteinase-9 (MMP-9) are associated with cognitive performance in patients with schizophrenia.

Neuropsychopharmacology reports
  • Noriko Kudo
  • ,
  • Hidenaga Yamamori
  • ,
  • Tamaki Ishima
  • ,
  • Kiyotaka Nemoto
  • ,
  • Yuka Yasuda
  • ,
  • Michiko Fujimoto
  • ,
  • Hirotsugu Azechi
  • ,
  • Tomihisa Niitsu
  • ,
  • Shusuke Numata
  • ,
  • Manabu Ikeda
  • ,
  • Masaomi Iyo
  • ,
  • Tetsuro Ohmori
  • ,
  • Masaki Fukunaga
  • ,
  • Yoshiyuki Watanabe
  • ,
  • Kenji Hashimoto
  • ,
  • Ryota Hashimoto

40
2
開始ページ
150
終了ページ
156
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/npr2.12098

AIM: Matrix metalloproteinase-9 (MMP-9) has been shown to modulate synaptic plasticity and may contribute to the pathophysiology of schizophrenia. This study investigated the peripheral levels of MMP-9 and its association with cognitive functions in patients with schizophrenia to see the possible involvement of MMP-9 in pathophysiology of schizophrenia, especially in cognitive decline. METHODS: We measured the plasma levels of MMP-9 in 257 healthy controls and 249 patients with schizophrenia, including antipsychotic drug-free patients. We also explored the possible association between plasma MMP-9 levels and cognitive performance in healthy controls and patients with schizophrenia using the Wechsler Adult Intelligence Scale, Third Edition (WAIS- III), the Wechsler Memory Scale-Revised (WMS-R), and the Rey Auditory Verbal Learning Test (AVLT). RESULTS: We found that the plasma levels of MMP-9 were significantly higher in patients with schizophrenia, including antipsychotic drug-free patients, than in healthy controls. We found a significant negative association between plasma MMP-9 levels and cognitive performance in controls and patients with schizophrenia. CONCLUSION: Together, these convergent data suggest a possible biological mechanism for schizophrenia, whereby increased MMP-9 levels are associated with cognitive impairment.

リンク情報
DOI
https://doi.org/10.1002/npr2.12098
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32022478

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