This paper presents the shake table tests and the analysis for evaluating the dynamic interaction of a RC column with a pile foundation and soil system. In case of a small input motion, both the structure and the soil were linear and the inertial interaction was dominant in the response of the pile foundation. Increasing the shaking level, the effect of kinematic interaction on the response became major and when the RC column became nonlinear, the pile's behavior was strongly affected by the soil deformation and the dynamic interaction between the structure and the soil became smaller.