Yoshiaki Kitamura

Profile Information

Affiliation: Faculty of Engineering, Gifu University
: (Concurrent)Graduate School of Natural Science and Technology
: (Concurrent)United Graduate School of Drug Discovery and Medical Information Sciences
: (Concurrent)Center for One Medicine Innovative Translational Research

Degree: 博士（薬学）(岐阜薬科大学)

J-GLOBAL ID: 200901074033822776
researchmap Member ID: 6000010466

External link: https://www1.gifu-u.ac.jp/~kitam_rg/

核酸を基軸とした創薬分子設計／核酸医薬創製のための反応開発／癌診断用PETプローブの開発／生理活性高分子の簡便標識化法の開発

Research Interests

Research Areas

Life sciences / Pharmaceuticals - chemistry and drug development / Medicinal chemistry

Research History

Jan, 2023 - Present

Center for One Medicine Innovative Translational Research, Gifu University
Dec, 2021 - Present

United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University
Apr, 2017 - Present

Graduate School of Natural Science and Technology, Gifu University
2008 - Present

Faculty of Engineering, Gifu University
Apr, 2013 - Mar, 2014

Department of Chemistry and Chemical Biology, Harvard University
Jun, 2011 - Mar, 2013

Administrative Staff, Nagoya Industrial Science Research Institute

Education

Apr, 2006 - Dec, 2007

Graduate School Department of Pharmaceutical Science, Gifu Pharmaceutical University
Apr, 2004 - Mar, 2006

Graduate School Department of Pharmaceutical Science, Gifu Pharmaceutical University
Apr, 2000 - Mar, 2004

Department of Public Health Pharmacy, Faculty of Pharmaceutical Science, Gifu Pharmaceutical University

Awards

Feb, 2021

味の素研究企画賞, カルベンを利用した核酸オリゴマーの実用的合成法の開発, 有機合成化学協会

喜多村徳昭
Jul, 2015

学術奨励賞, 核酸医薬開発を目指した化学修飾核酸の創製, 日本薬学会東海支部

喜多村徳昭
Aug, 2014

奨励賞, 次世代医薬創出のためのPET標識化法の開発, 有機合成化学協会東海支部

喜多村徳昭

Papers

Azidomethylation of Nucleobases and Related N-Heterocycles, Benzazoles, and Bis(arene)sulfonimides Using Azidomethyl Esters with Silyl Triflates

Ryoga Sawahata, Yuga Takagi, Yoshiaki Kitamura

Organic Letters, 2024 Peer-reviewedLast authorCorresponding author
A Diversifiable Synthetic Platform for the Discovery of New Carbasugar SGLT2 Inhibitors Using Azide–Alkyne Click Chemistry

Yoshiaki Kitamura, Mahmoud Kandeel, Erina Oba, Chiori Iwai, Keitaro Iritani, Nanako Nagaya, Reo Namura, Hiroshi Katagiri, Hiroshi Ueda, Yukio Kitade

Chemical and Pharmaceutical Bulletin, 71(3) 240-249, Mar, 2023 Peer-reviewedLead authorCorresponding author
Design of supramolecular hybrid nanomaterials comprising peptide-based supramolecular nanofibers and in situ generated DNA nanoflowers through rolling circle amplification

Shintaro Sugiura, Yuki Shintani, Daisuke Mori, Sayuri L. Higashi, Aya Shibata, Yoshiaki Kitamura, Shin-ichiro Kawano, Koichiro M. Hirosawa, Kenichi G.N. Suzuki, Masato Ikeda

Nanoscale, 15(3) 1024-1031, Nov, 2022 Peer-reviewed
Formation of Supramolecular Nanostructures through in Situ Self‐Assembly and Post‐Assembly Modification of a Biocatalytically Constructed Dipeptide Hydrazide**

Yuki Shintani, Taku Ohtomi, Aya Shibata, Yoshiaki Kitamura, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Masato Ikeda

Chemistry – A European Journal, 28(8) e202104421, Feb, 2022 Peer-reviewed
A new approach for the synthesis of N-β-enaminocarbonyl 2-oxazolidinones through ring transformation reactions of uracil

Yoshiaki Kitamura, Yuto Ohshima, Yuki Nagaya

Tetrahedron Letters, 88 153554-153554, Jan, 2022 Peer-reviewedLead authorCorresponding author
Introduction of an Oxidation-responsive 4-Boronobenzyl Group into an Oligonucleotide through a Postmodification Approach

Nanami Shirakami, Yugo Kawaki, Sayuri L. Higashi, Aya Shibata, Yoshiaki Kitamura, Sharina Abu Hanifah, Lim Lee Wah, Masato Ikeda

Chemistry Letters, 50(7) 1412-1415, Jul, 2021 Peer-reviewed
Construction of a reduction-responsive oligonucleotide via a post-modification approach utilizing 4-nitrophenyl diazomethane

Nanami Shirakami, Sayuri L. Higashi, Yugo Kawaki, Yoshiaki Kitamura, Aya Shibata, Masato Ikeda

Polymer Journal, 53(6) 741-746, Jun, 2021 Peer-reviewed
Sulfonamide antibiotics inhibit RNAi by binding to human Argonaute protein 2 PAZ

Kitamura, Y, Kandeel, M, Kondo, T, Tanaka, A, Makino, Y, Miyamoto, N, Shibata, A. Ikeda, M, Kitade, Y

Bioorganic & Medicinal Chemistry Letters, 30(24) 127637, Dec, 2020 Peer-reviewedLead authorCorresponding author
Effect of side chain phenyl group on the self-assembled morphology of dipeptide hydrazides

Taku Ohtomi, Sayuri L Higashi, Daisuke Mori, Aya Shibata, Yoshiaki Kitamura, Masato Ikeda

PeptideScience, Oct, 2020 Peer-reviewed
Novel Ring Transformation of Uracils to 2-Oxazolidinones

Yoshiaki Kitamura, Yuki Nagaya, Yuto Ohshima, Daiki Kato, Asuki Ohguchi, Hiroshi Katagiri, Masato Ikeda, Yukio Kitade

Heterocycles, 100(4) 622-631, Mar, 2020 Peer-reviewedLead authorCorresponding author
ABCE1 Acts as a Positive Regulator of Exogenous RNA Decay.

Takuto Nogimori, Koichi Ogami, Yuka Oishi, Ryoya Goda, Nao Hosoda, Yoshiaki Kitamura, Yukio Kitade, Shin-Ichi Hoshino

Viruses, 12(2), Feb, 2020 Peer-reviewed
Self-assembly and hydrogel formation ability of Fmoc-dipeptides comprising α-methyl-L-phenylalanine

Hanae Arakawa, Kumi Takeda, Sayuri L. Higashi, Aya Shibata, Yoshiaki Kitamura, Masato Ikeda

Polymer Journal, 52 923-930, Jan, 2020 Peer-reviewed
Practical and reliable synthesis of 2',3',5',5″-tetradeuterated uridine derivatives.

Noriko Miyamoto, Hiroki Ohno, Yoshiaki Kitamura, Kwihwan Park, Yoshinari Sawama, Hironao Sajiki, Yukio Kitade

Nucleosides, nucleotides & nucleic acids, 39(1-3) 236-244, 2020 Peer-reviewed
Chemical stimulus-responsive supramolecular hydrogel formation and shrinkage of a hydrazon-containing short peptide derivative

Takumi Sugiura, Takurou Kanada, Daisuke Mori, Hiroyuki Sakai, a, Aya Shibata, Yoshiaki Kitamura, Masato Ikeda

Soft Matter, 16(4) 899-906, Dec, 2019 Peer-reviewed
Hybrid Soft Nanomaterials Composed of DNA Microspheres and Supramolecular Nanostructures of Semi-artificial Glycopeptides

Higashi, S.L., Shibata, A., Kitamura, Y., Hirosawa, K.M., Suzuki, K.G.N., Matsuura, K., Ikeda, M.

Chemistry - A European Journal, 25(51) 11955-11962, Jul, 2019 Peer-reviewed
Dom34 mediates targeting of exogenous RNA in the antiviral OAS/RNase L pathway

Nogimori, T., Nishiura, K., Kawashima, S., Nagai, T., Oishi, Y., Hosoda, N., Imataka, H., Kitamura, Y., Kitade, Y., Hoshino, S.-I.

Nucleic Acids Research, 47(1) 432-449, Jan, 2019 Peer-reviewed
Cyclic arylopeptoid oligomers: synthesis and conformational propensities of peptide-mimetic aromatic macrocycles

Masahide Hayakawa, Ayaka Ohsawa, Kumi Takeda, Ryo Torii, Yoshiaki Kitamura, Hiroshi Katagiri, Masato Ikeda

Organic & Biomolecular Chemistry, 16(44) 8505-8512, Nov, 2018 Peer-reviewed
Synthesis of cationic glucosamino nucleic acids for stabilizing oligonucleotides

Kitamura, Y., Moribe, S., Kitade, Y.

Bioorganic and Medicinal Chemistry Letters, 28(19) 3174-3176, Oct, 2018 Peer-reviewedLead authorCorresponding author
Introduction of 2-O-benzyl abasic nucleosides to the 3 '-overhang regions of siRNAs greatly improves nuclease resistance

Yuki Nagaya, Yoshiaki Kitamura, Aya Shibata, Masato Ikeda, Yukihiro Akao, Yukio Kitade

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27(24) 5454-5456, Dec, 2017 Peer-reviewed
Nucleobase azide-ethynylribose click chemistry contributes to stabilizing oligonucleotide duplexes and stem-loop structures

Yoshiaki Kitamura, Ryo Asakura, Koki Terazawa, Aya Shibata, Masato Ikeda, Yukio Kitade

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27(12) 2655-2658, Jun, 2017 Peer-reviewed

Misc.

SGLT阻害薬候補化合物ライブラリーの構築を目指したカルバグルコース誘導体の合成

大羽栄里奈, 岩井千織, 長屋奈那子, 片桐洋史, 上田浩, 上田浩, 北出幸夫, 北出幸夫, MAHMOUD Kandeel, 池田将 …

日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集, 2020, 2020
クリック反応を利用したコレステロール修飾dsRNAの開発

近藤良徳, 小縣綾, 小縣綾, 河出美和, 石川竣也, 齋竹真美子, 中島礼美, 柴田綾, 喜多村徳昭, 池田将 …

日本核酸医薬学会年会講演要旨集, 3rd, 2017
核酸医薬の開発を指向した2‐5Aを母核とするベンゼン骨格導入型新規人工核酸の創製

山下真世, 白石孝雄, 喜多村徳昭, 上野義仁, 北出幸夫

中部化学関係学協会支部連合秋季大会講演予稿集, 40th 147, Nov 7, 2009
クリック反応を用いたオリゴアデニル酸2‐5Aの標識化

白石孝雄, 喜多村徳昭, 上野義仁, 北出幸夫

日本薬学会年会要旨集, 129th(2) 79, Mar 5, 2009
RNA創薬を指向したグルコサミン結合型核酸オリゴマーの開発

坂野慎哉, 森田健介, 安藤隆幸, 喜多村徳昭, 上野義仁, 北出幸夫

中部化学関係学協会支部連合秋季大会講演予稿集, 40th, 2009
ORGN 77-Chemoselective and mild hydrogenation methods catalyzed by heterogeneous Pd/C-ethylendiamine, Pd-fibroin or Pd-polyethyleneimine complexes

Hironao Sajiki, Shigeki Mori, Yoshiaki Kitamura, Takashi Ikawa, Yasunari Monguchi, Tomohiro Maegawa

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 234, Aug, 2007
ORGN 538-Ligand-free and heterogeneous Pd/C catalyzed Suzuki-Miyaura coupling reaction toward the synthesis of heterobiaryl derivatives

Satoko Sako, Yoshiaki Kitamura, Takahiro Udzu, Tomohiro Maegawa, Yasunari Monguchi, Hironao Sajiki

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 234, Aug, 2007
ORGN 270-Mild and phosphine-free Suzuki-Miyaura coupling reaction catalyzed by Pd/C

Yoshiaki Kitamura, Satoko Sako, Takahiro Udzu, Ai Sakurai, Asami Tanaka, Yusuke Kobayashi, Utpal Bora, Takanori Kurita, Atsushi Kozaki, Tomohiro Maegawa …

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 232, Sep, 2006
Ligand-free Suzuki-Miyaura reaction catalysed by Pd/C at room temperature (pg 593, 2004)

H Sajiki, T Kurita, A Kozaki, GL Zhang, Y Kitamura, T Maegawa, K Hirota

JOURNAL OF CHEMICAL RESEARCH-S, (5) 344-344, May, 2005
Easy, copper-, ligand- and amine-free sonogashira coupling reaction catalyzed by palladium on carbon at low catalyst loading and by exposure to air (March, pg 619, 2005)

H Sajiki, G Zhang, Y Kitamura, T Maegawa, K Hirota

SYNLETT, (6) 1046-1046, Apr, 2005
Efficient protocol for the phosphine-free Suzuki-Miyaura reaction catalyzed by palladium on carbon at room temperature (Mar, pg 537, 2005)

H Sajiki, T Kurita, A Kozaki, G Zhang, Y Kitamura, T Maegawa, K Hirota

SYNTHESIS-STUTTGART, (5) 852-852, Apr, 2005

Books and Other Publications

医薬品モダリティの特許戦略と技術開発動向

(Role: Contributor)

May, 2019
Current Protocols in Nucleic Acid Chemistry

喜多村徳昭, 上野義仁, 北出幸夫

Jun, 2014
固定化触媒のルネッサンス

Kitamura Yoshiaki(Gifu Pharmaceutical University, Sajiki Hironao(Gifu, Pharmaceutical University (Role: Contributor)

Jul, 2007

Presentations

151

クリックケミストリーを利用したカルバグルコース型SGLT阻害薬の創製

入谷桂太郎, 大羽栄里奈, 岩井千織, 長屋奈那子, 片桐洋史, 上田浩, Kandeel Mahmoud, 北出幸夫, 池田将, 喜多村徳昭

日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
SGLT阻害薬候補化合物ライブラリーの構築を目指したカルバグルコース誘導体の合成

大羽栄里奈, 岩井千織, 長屋奈那子, 片桐洋史, 上田浩, 北出幸夫, Kandeel Mahmoud, 池田将, 喜多村徳昭

日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2020, Nov, 2020
喜多村徳昭, 岩井千織, 長屋奈那子, 大羽栄里奈, 片桐洋史, 上田浩, 北出幸夫, Mahmoud Kandeel, 池田将

新規SGLT阻害薬開発を目指したカルバグルコース誘導体の多様性指向型合成

日本薬学会第140年会, Mar 26, 2020
DNAとペプチド超分子ナノ構造体からなる新規多成分超分子ナノ材料の創製とその応用

東小百合, 柴田綾, 喜多村徳昭, 廣澤幸一郎, 鈴木健一, 松浦和則, 池田将

日本化学会第100春季年会, Mar 22, 2020
核酸とペプチド誘導体のself-sortingを利用した新規超分子ナノ材料の創製

東小百合, 柴田綾, 喜多村徳昭, 廣澤幸一郎, 鈴木健一, 池田将

第4回LLPS研究会・ASUKA若手交流会2019, Dec 9, 2019
嗅覚受容体における新規短鎖脂肪酸受容体の同定

八橋茉利奈, 吉田泰徳, 今枝孝夫, 西川将司, 中野駿, 喜多村徳昭, 池田将, 榊原清美, 本山ユミ, 長瀬隆弘, 上田浩

第42回日本分子生物学会年会, Dec 3, 2019
ウラシル環の新規開環反応の開発とβ₋アミノ酸類合成への応用

大島佑斗, 長屋優貴, 伊藤雄亮, 柳田彩斗, 池田将, 喜多村徳昭

日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2019, Nov 10, 2019
A novel ring transformation of uracils to 2-oxazolidinones and 2-imidazolidinones

Yoshiaki Kitamura, Yuki Nagaya, Asuki Ohguchi, Daiki Kato, Yuto Ohshima, Yukio Kitade, Hiroshi Katagiri, Masato Ikeda

第46回国際核酸化学シンポジウム・日本核酸化学会第3回年会, Oct 29, 2019
核酸とペプチドからなる超分子ナノ構造体の階層構造解明

東小百合, 柴田綾, 喜多村徳昭, 廣澤幸一郎, 鈴木健一, 池田将

第9回CSJ化学フェスタ2019, Oct 17, 2019
還元応答性タンパク質のOne-step構築

柴田晴奈, 喜多村徳昭, 柴田綾, 池田将

第9回CSJ化学フェスタ2019, Oct 15, 2019
ポスト修飾を利用した還元応答性核酸の創製

白神菜々美, 山川萌奈子, 東小百合, 柴田綾, 喜多村徳昭, 池田将

日本ケミカルバイオロジー学会第14回年会, Jun 12, 2019
核酸とペプチドからなる新規刺激応答性超分子ナノ材料の創製

東小百合, 柴田綾, 喜多村徳昭, 廣澤幸一郎, 鈴木健一, 池田将

日本ケミカルバイオロジー学会第14回年会, Jun 10, 2019
新規SGLT2阻害薬開発を目指した1-置換カルバグルコース誘導体の多様性指向型合成

喜多村徳昭, 岩井千織, 長屋奈那子, 上田浩, 片桐洋史, Mahmoud Kandeel, 池田将, 北出幸夫

第36回メディシナルケミストリーシンポジウム, Nov 28, 2018
Synthesis of various furanoid glycal derivatives and their use as stimuli-responsive tools by precise control of their decomposition to furan derivatives

Yoshiaki Kitamura, Koki Terazawa, Yuki Nagaya, Ryo Asakura, Katsuki Tanaka, Masato Ikeda, Yukio Kitade

第45回国際核酸化学シンポジウム・日本核酸化学会第2回年会, Nov 7, 2018
新規短鎖脂肪酸受容体としての嗅覚受容体OR51E2の同定と解析

八橋茉利奈, 西川将司, 中野駿, 喜多村徳昭, 池田将, 本山ユミ, 榊原清美, 今枝孝夫, 山川央, 長瀬隆弘, 上田浩

日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2018, Nov 4, 2018
環状芳香族性ペプトイド四量体の合成および動的構造変化の解析

大澤彩香, 武田香実, 早川征秀, 喜多村徳昭, 片桐洋史, 池田将

第8回CSJ化学フェスタ2018, Oct 23, 2018
機能性短鎖RNA医薬開発における体内の安定・活性化向上を目指した修飾核酸技術の創製

喜多村徳昭

「核酸医薬」セミナー, Sep 7, 2018 Invited
RNA医薬創出を指向した化学修飾核酸の創製

喜多村徳昭

第11回ナノバイオ若手ネットワーキングシンポジウム, Jun 15, 2018
標的指向型アフィボディ修飾RNAの開発

東小百合, 柴田綾, 喜多村徳昭, 池田将, 北出幸夫

日本ケミカルバイオロジー学会第13回年会, Jun 12, 2018
塩基部欠損ヌクレオシド類を 3’末端に有する siRNA の合成と性質評価

長屋優貴, 喜多村徳昭, 柴田綾, 池田将, 赤尾幸博, 北出幸夫

日本薬学会第138年会, Mar 27, 2018

Teaching Experience

Professional Memberships

Feb, 2018

The Japanese Biochemical Society
Jul, 2017

The Japan Society of Nucleic Acids Chemistry
Nov, 2015

The Society of Synthetic Organic Chemistry, Japan
May, 2015

The Japanese Society for Process Chemistry
May, 2009

Japanese Society for Chemical Biology
Dec, 2008

The Chemical Society of Japan
Jan, 2008

American Chemical Society
Dec, 2004

The Pharmaceutical Society of Japan

Works

東海3大学新技術説明会

2010

Research Projects

Development of sophisticated small RNAs utilizing the properties of functional groups

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

KITAMURA Yoshiaki, KITADE YUKIO, IKEDA MASATO, AYA SHIBATA
Owing to the development of RNA medicine, discovery of practical RNA molecules and synthesis of nucleic acid PET probes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

KITADE Yukio
Novel modification method of oligonucleotides for siRNA medicine

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2013

KITAMURA Yoshiaki, KITADE Yukio, UENO Yoshihito, IKEDA Masato
マイクロRNAの機能を利用した難治性疾患の早期診断法及び治療法の開発

文部科学省「特別経費」, 文部科学省, 2011 - 2012

北出幸夫

Industrial Property Rights

特許第5721180号芳香族化合物、並びに、それを用いたオリゴヌクレオチド誘導体合成用修飾担体、オリゴヌクレオチド誘導体及びオリゴヌクレオチド構築物

北出幸夫, 喜多村徳昭
特開2012-188420 エチニル基含有環状イミド化合物、並びに、それを用いたチオール基修飾剤及びそれを用いたアミノ基修飾剤

北出幸夫, 喜多村徳昭
WO2011-071078 芳香族化合物、並びに、それを用いたオリゴヌクレオチド誘導体合成用修飾担体、オリゴヌクレオチド誘導体及びオリゴヌクレオチド構築物

北出幸夫, 喜多村徳昭
5871231 エチニル基含有環状イミド化合物、並びに、それを用いたチオール基修飾剤及びそれを用いたアミノ基修飾剤

KITADEYUKIO, KITAMURAYOSHIAKI
5721180 AROMATICCOMPOUND，MODIFICATIONCARRIERTHATUSESSAMEANDISUSEDFORSYNTHESIZINGANOLIGONUCLEOTIDEDERIVATIVE，OLIGONUCLEOTIDEDERIVATIVE，ANDOLIGONUCLEOTIDECONSTRUCT

KITADEYUKIO, KITAMURAYOSHIAKI

Social Activities

講演講師

Lecturer

技術情報協会, 講演会, Sep 7, 2018 - Sep 7, 2018

Other

甲種危険物取扱者

Dec, 2008 - Dec, 2008
第一種衛生管理者

Jun, 2008 - Jun, 2008
薬剤師

Jul, 2004 - Jul, 2004

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Education

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