論文

査読有り 国際誌
2020年8月14日

Spontaneous regeneration of the mandible following hemimandibulectomy for medication-related osteonecrosis of the jaw: A case report.

Medicine
  • Shinpei Matsuda
  • ,
  • Hisato Yoshida
  • ,
  • Minako Shimada
  • ,
  • Hitoshi Yoshimura

99
33
開始ページ
e21756
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/MD.0000000000021756

RATIONALE: Medication-related osteonecrosis of the jaw decreases quality of life of patients with cancer. The debate about it continues regarding the risk factors, etiology, and treatment methods, and so on. Also, spontaneous regeneration of the mandible is clinically rare. PATIENT CONCERNS: A 67-year-old woman presented to the authors' department complaining of pain, swelling, and pus discharge from a fistula. She previously had breast cancer bone metastases and had received antiresorptive intravenous bisphosphonate. DIAGNOSIS: The patient was diagnosed with medication-related osteonecrosis of the jaw. INTERVENTIONS: She received conservative therapy with antibiotics and surgical therapy as sequestrectomy under general anesthesia; however, the lesion did not heal. Thirty months after the MRONJ diagnosis, when she was 70 years' old, she underwent a left hemimandibulectomy without reconstruction under general anesthesia. OUTCOMES: Spontaneous regeneration of the mandible was observed by follow-up imaging examinations. The patient has no current subjective or objective symptoms. LESSONS: This is the first case report of the spontaneous mandibular regeneration after surgery for medication-related osteonecrosis of the jaw. Additionally, this case was the oldest patient among the published mandibular regeneration cases.

リンク情報
DOI
https://doi.org/10.1097/MD.0000000000021756
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32872069
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437848
ID情報
  • DOI : 10.1097/MD.0000000000021756
  • PubMed ID : 32872069
  • PubMed Central 記事ID : PMC7437848

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