Toshinori Yoshihara

Profile Information

Affiliation: Juntendo University

Degree: 博士（スポーツ健康科学）(順天堂大学大学院)
修士（スポーツ健康科学）(順天堂大学大学院)
学士（教育学）(山口大学)

Researcher number: 20722888
J-GLOBAL ID: 201801021306586110
researchmap Member ID: B000319143

External link: https://www.juntendo.ac.jp/graduate/kenkyudb/search/researcher.php?MID=5678

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Graduate School of Health and Sports Science., Juntendo University
Apr, 2023 - Present

Faculty of Health and Sports Science Juntendo University Department of Sports Science, Juntendo University
Apr, 2020 - Mar, 2023

Assistant Professor, Graduate School of Health and Sports Science., Juntendo University
Apr, 2020 - Mar, 2023

Assistant Professor, Faculty of Health and Sports Science Juntendo University Department of Sports Science, Juntendo University
Apr, 2015 - Mar, 2020

Research Assistant Professor, COI project center, Juntendo University
Oct, 2017 - Oct, 2019

Visiting Scholar, University of Florida, Postdoctoral Fellowship for Research Abroad of Japan Society for the Promotion of Science
Apr, 2014 - Mar, 2015

Postdoctoral Fellow, Institute of Health and Sports Science & Medicine, Juntendo University
Apr, 2011 - Mar, 2014

JSPS Research Fellow, The Japan Society for the Promotion of Science

Education

Apr, 2011 - Mar, 2013

Doctor of Sports Health & Science, Graduate School of Health and Sports Science, Juntendo University
Apr, 2009 - Mar, 2011

Master of Sports Health & Science, Graduate School of Health and Sports Science, Juntendo University
Apr, 2005 - Mar, 2009

Bachelor of Education, Faculty of Education, Yamaguchi University

Papers

Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast-twitch muscle in rats.

Munehiro Uda, Toshinori Yoshihara, Noriko Ichinoseki-Sekine, Takeshi Baba

Physiological reports, 12(5) e15969, Mar, 2024
Pre-heating stress associated with acute oral leucine supplementation effects in rat gastrocnemius muscle: Implications for protein synthesis signaling pathways.

Toshinori Yoshihara, Shohei Dobashi, Hisashi Naito

Journal of thermal biology, 119 103801-103801, Jan 30, 2024
Effects of preconditioning with heat stress on acute exercise-induced intracellular signaling in male rat gastrocnemius muscle.

Toshinori Yoshihara, Shohei Dobashi, Hisashi Naito

Physiological reports, 12(1) e15913, Jan, 2024
Correction: Ishihara et al. Association between Daily Physical Activity and Locomotive Syndrome in Community-Dwelling Japanese Older Adults: A Cross-Sectional Study. Int. J. Environ. Res. Public Health 2022, 19, 8164.

Yoshihiko Ishihara, Hayao Ozaki, Takashi Nakagata, Toshinori Yoshihara, Toshiharu Natsume, Tomoharu Kitada, Masayoshi Ishibashi, Pengyu Deng, Yasuyuki Yamada, Hiroyuki Kobayashi …

International journal of environmental research and public health, 20(18), Sep 13, 2023
Impacts of myosin heavy chain phenotypes on recovery of leg extension force after ACL-reconstructed knee

Tetsuo Kobayashi, Yuji Ogura, Satoshi Kishiro, Mitsutoshi Kurosaka, Toshinori Yoshihara, Ryo Kakigi, Naoki Minakawa, Kenji Uehara, Tomohiro Suzuki, Katsumasa Goto …

The Journal of Physical Fitness and Sports Medicine, 12(3) 77-85, May 25, 2023
Cage restriction-induced physical inactivity promotes subsequent hepatic apoptosis during tail suspension in young male rats.

Shohei Dobashi, Hisashi Naito, Toshinori Yoshihara

Physiological reports, 11(10) e15695, May, 2023
Exercise training improves obesity-induced inflammatory signaling in rat brown adipose tissue.

Takamasa Tsuzuki, Toshinori Yoshihara, Noriko Ichinoseki-Sekine, Hiroyuki Kobayashi, Takayuki Negishi, Kazunori Yukawa, Hisashi Naito

Biochemistry and biophysics reports, 32 101398-101398, Dec, 2022
Effect of losartan treatment on Smad signaling and recovery from hindlimb unloading-induced soleus muscle atrophy in female rats.

Toshinori Yoshihara, Shohei Dobashi, Mizuki Takaragawa, Hisashi Naito

European journal of pharmacology, 931 175223-175223, Aug 18, 2022
Association between Daily Physical Activity and Locomotive Syndrome in Community-Dwelling Japanese Older Adults: A Cross-Sectional Study.

Yoshihiko Ishihara, Hayao Ozaki, Takashi Nakagata, Toshinori Yoshihara, Toshiharu Natsume, Tomoharu Kitada, Masayoshi Ishibashi, Pengyu Deng, Yasuyuki Yamada, Hiroyuki Kobayashi …

International journal of environmental research and public health, 19(13), Jul 3, 2022
Losartan treatment attenuates hindlimb unloading-induced atrophy in the soleus muscle of female rats via canonical TGF-β signaling.

Toshinori Yoshihara, Mizuki Takaragawa, Shohei Dobashi, Hisashi Naito

The journal of physiological sciences : JPS, 72(1) 6-6, Mar 9, 2022
Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles.

Shuo-Wen Chang, Toshinori Yoshihara, Takamasa Tsuzuki, Toshiharu Natsume, Ryo Kakigi, Shuichi Machida, Hisashi Naito

PloS one, 17(2) e0264171, 2022
Site-Specific Muscle Loss in the Abdomen and Anterior Thigh in Elderly Males with Locomotive Syndrome

Toshiharu Natsume, Hayao Ozaki, Takashi Nakagata, Toshinori Yoshihara, Tomoharu Kitada, Yoshihiko Ishihara, Pengyu Deng, Takuya Osawa, Shuji Sawada, Hiroyuki Kobayashi …

JOURNAL OF SPORTS SCIENCE AND MEDICINE, 20(4) 635-641, Dec, 2021
Alterations in renin-angiotensin receptors are not responsible for exercise preconditioning of skeletal muscle fibers.

Branden L Nguyen, Toshinori Yoshihara, Rafael Deminice, Jensen Lawrence, Mustafa Ozdemir, Hayden Hyatt, Scott K Powers

Sports medicine and health science, 3(3) 148-156, Sep, 2021
Serum albumin levels as a predictive biomarker for low-load resistance training programs' effects on muscle thickness in the community-dwelling elderly Japanese population: interventional study result.

Shuji Sawada, Hayao Ozaki, Toshiharu Natsume, Daiki Nakano, Pengyu Deng, Toshinori Yoshihara, Takuya Osawa, Hiroyuki Kobayashi, Shuichi Machida, Hisashi Naito

BMC geriatrics, 21(1) 464-464, Aug 18, 2021
The 30-s chair stand test can be a useful tool for screening sarcopenia in elderly Japanese participants.

Shuji Sawada, Hayao Ozaki, Toshiharu Natsume, Pengyu Deng, Toshinori Yoshihara, Takashi Nakagata, Takuya Osawa, Yoshihiko Ishihara, Tomoharu Kitada, Ken Kimura …

BMC musculoskeletal disorders, 22(1) 639-639, Jul 24, 2021
Angiotensin 1-7 protects against ventilator-induced diaphragm dysfunction.

Toshinori Yoshihara, Rafael Deminice, Hayden W Hyatt, Mustafa Ozdemir, Branden L Nguyen, Scott K Powers

Clinical and translational science, 14(4) 1512-1523, Jul, 2021
Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle.

Toshinori Yoshihara, Toshiharu Natsume, Takamasa Tsuzuki, Shuo-Wen Chang, Ryo Kakigi, Shuichi Machida, Takao Sugiura, Hisashi Naito

Journal of applied physiology (Bethesda, Md. : 1985), 130(4) 1214-1225, Feb 18, 2021
Calpains play an essential role in mechanical ventilation-induced diaphragmatic weakness and mitochondrial dysfunction.

Hayden W Hyatt, Mustafa Ozdemir, Toshinori Yoshihara, Branden L Nguyen, Rafael Deminice, Scott K Powers

Redox biology, 38 101802-101802, Jan, 2021
Muscle Size and Strength of the Lower Body in Supervised and in Combined Supervised and Unsupervised Low-Load Resistance Training.

Hayao Ozaki, Shuji Sawada, Takuya Osawa, Toshiharu Natsume, Toshinori Yoshihara, Pengyu Deng, Shuichi Machida, Hisashi Naito

Journal of sports science & medicine, 19(4) 721-726, Dec, 2020
Protective effects of acute exercise preconditioning on disuse-induced muscular atrophy in aged muscle: a narrative literature review.

Toshinori Yoshihara, Hisashi Naito

The journal of physiological sciences : JPS, 70(1) 55-55, Nov 27, 2020

Awards

Mar, 2017

Grand Prize, The Japanese Society of Health, Fitness and Nutrition

Toshinori Yoshihara
Mar, 2015

Incentive Award, The Japanese Society of Health, Fitness and Nutrition

Toshinori Yoshihara
Apr, 2014

1st Prize, Japanese society of Physical Fitness and Sports Medicine

Toshinori Yoshihara
Apr, 2012

Special Award, The 20th International Congress on Sports Sciences for Students

Toshinori Yoshihara
Sep, 2010

Young Investigator Award, Japanese society of Physical Fitness and Sports Medicine

Toshinori Yoshihara

Research Projects

ミトコンドリア機能に着目した糖尿病における呼吸筋機能低下メカニズムの解明

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2025

関根紀子, 吉原利典, 福典之, 小林裕幸
骨格筋適応の性差を司るアンジオテンシン受容体制御機構の解明

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2025

吉原利典, 内藤久士, 町田修一, 柿木亮
若年期に刻むマッスルメモリーで寝たきりゼロは実現できるか？

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jul, 2021 - Mar, 2024

吉原利典
非典型IκBーNF-κBシグナリングを介した骨格筋萎縮メカニズムの解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

小倉裕司, 黒坂光寿, 吉原利典
Lactate mediated histone modification prevent sarcopenia

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Mechanisms of hydrogen sulfide prevents mechanical ventilation-induced diaphragm atrophy and dysfunction

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Ichinoseki-Sekine Noriko
Epigenetic mechanisms for prevention of skeletal muscle atrophy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Toshinori Yoshihara
Epigenetic mechanisms of skeletal muscle atrophy

Overseas Research Fellowships, Japan Society for the Promotion of Science, Oct, 2017 - Oct, 2019

Toshinori Yoshihara
Exercise time and circadian rhythm may impact maximal skeletal muscle hypertrophy

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

CHANG SHUOWEN, NATIO Hisashi, YOSHIHARA Toshinori
Effects of exercise on prevention and improvement of type 2 diabetes from perspective of redox system

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2016 - Mar, 2018

Tsuzuki Takamasa, NAITO Hisashi, GOTO Sataro, YOSHIHARA Toshinori
Effect of heat stress on body fat mass and muscle mass in mice with sarcopenia obesity

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2016 - Mar, 2018

Goto Ayumi, NAITO Hisashi, KAKIGI Ryo, YOSHIHARA Toshinori, TSUZUKI Takamasa
Development of improved mechanical ventilation model for recovery(Fostering Joint International Research)

Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research), Fund for the Promotion of Joint International Research (Fostering Joint International Research), Japan Society for the Promotion of Science, 2016 - 2018

Ichinoseki-Sekine Noriko, Powers Scott K, Smuder Ashley J, Naito Hisashi, Yoshihara Toshinori
Muscle memory in space environment to be elucidated by epigenetics.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Yoshihara Toshinori
熱ストレス負荷が骨格筋萎縮を抑制するメカニズムの解明

特別研究員奨励費, 日本学術振興会, Apr, 2011 - Mar, 2014

吉原利典
熱ストレス負荷が骨格筋萎縮を抑制するメカニズムの解明

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2011 - 2013

吉原利典

Misc.

146

Symposium29-1

吉原利典

体力科学, 72(1), 2023
REGULATION OF SKELETAL MUSCLE RECEPTOR EXPRESSION UNRAVELING SEX DIFFERENCES IN THE DEVELOPMENT OF SARCOPENIA

吉原利典

若手研究者のための健康科学研究助成成果報告書, (37), 2023
多周波数BIA装置の相違は高齢者における骨格筋量の評価に影響を及ぼす

沢田秀司, 劉振岳, 谷本道哉, トウ鵬宇, 吉原利典, 内藤久士, 町田修一

日本サルコペニア・フレイル学会誌, 7(Supplement), 2023
12週間の自体重レジスタンストレーニングが女性高齢者のバランス能力と転倒関連自己効力感に及ぼす影響

劉振岳, 沢田秀司, とう鵬宇, 吉原利典, 内藤久士, 町田修一

日本サルコペニア・フレイル学会誌, 7(Supplement), 2023
Nrf2欠損は力学的過負荷による骨格筋の肥大を促進する

都築孝允, 吉原利典, 内藤久士, 根岸隆之, 湯川和典

日本運動生理学会大会プログラム・抄録集, 31st, 2023
Epigenetics mechanisms of the prevention of sarcopenia

吉原利典

月刊Precision Medicine, 5(4) 371-375, Apr, 2022
運動適応におけるエピジェネティクス骨格筋におけるエピジェネティック修飾の加齢変化

吉原利典

体育の科学, 72(12), 2022
自体重レジスタンストレーニングを用いたオンライン運動教室が中高齢者の下肢の身体機能に及ぼす影響

劉振岳, 沢田秀司, 吉原利典, とう鵬宇, 町田修一, 内藤久士

健康支援, 24(1), 2022
双方向通信によるオンライン運動教室は生活機能および精神的健康度の改善に有用である

沢田秀司, 劉振岳, 吉原利典, とう鵬宇, 町田修一, 内藤久士

健康支援, 24(1), 2022
ロコモの評価には30秒椅子立ち上がりテストと最大歩行速度の組み合わせが有用である

沢田秀司, トウ鵬宇, 吉原利典, 木村憲, 佐藤信紘, 内藤久士, 町田修一

日本サルコペニア・フレイル学会誌, 6(Supplement), 2022
Epigenetic mechanisms of sarcopenia

吉原利典

Bio Clinica, 36(9) 879-883, Aug, 2021
通常歩行速度1.4m/s以下および最大歩行速度1.9m/s以下はロコモのリスクがある

沢田秀司, とう鵬宇, 吉原利典, 木村憲, 佐藤信紘, 町田修一, 内藤久士

日本サルコペニア・フレイル学会誌, 5(Supplement), 2021
自立型高齢者住宅の入居者におけるロコモ度と認知機能の関連性

大野佳南子, 大野佳南子, 沢田秀司, 宮崎祐, 桑田勇人, 吉原利典, とう鵬宇, 佐藤信紘, 涌井佐和子, 内藤久士 …

日本サルコペニア・フレイル学会誌, 5(Supplement), 2021
トレーナビリティの性差を左右する骨格筋の制御機構に関する基礎研究

吉原利典, 土橋祥平, 土橋祥平, 寳川美月, 棗寿喜

日本運動生理学会大会プログラム・抄録集, 29th, 2021
常圧低酸素環境下での高強度トレーニングがラット腓腹筋のミトコンドリア関連タンパク質発現に及ぼす影響

土橋祥平, 吉原利典, 内藤久士

日本運動生理学会大会プログラム・抄録集, 29th, 2021
骨格筋電気刺激に対するモノカルボン酸トランスポーター発現応答における性差

吉原利典, 棗寿喜, 土橋祥平, 内藤久士

日本運動生理学会大会プログラム・抄録集, 29th, 2021
Epigenetic mechanisms of sarcopenia

22(14) 74-77, Dec, 2020
Epigenetic mechanisms of sarcopenia

吉原利典

月刊細胞, 52(12) 693-696, Oct, 2020
血清アルブミンレベルは自体重レジスタンストレーニングの筋肥大効果に影響を及ぼす

沢田秀司, 尾崎隼朗, 棗寿喜, とう鵬宇, 吉原利典, 大澤拓也, 町田修一, 内藤久士

日本老年医学会雑誌, 57(Suppl.) 66-66, Jul, 2020
120

Epigenetic mechanisms for prevention of skeletal muscle atrophy.

Toshinori Yoshihara

Impact, 2019(7) 81-83, Aug, 2019 Invited

Books and Other Publications

Science and Development of Muscle Hypertrophy 2nd Edition

(Role: Joint author)

Nov, 2021
パワーズ運動生理学 : 体力と競技力向上のための理論と応用

(Role: Joint translator) (Original Author(s): Powers, Scott K, Scott Kline, Howley, Edward T)

Aug, 2020 (ISBN: 9784815701901)
ニュー運動生理学〈1〉

内藤久士, 町田修一, 吉原利典, 宮村実晴 (Role: Joint author, 4骨格筋の肥大と萎縮)

真興交易医書出版部, Sep, 2014 (ISBN: 4880038865)

Committee Memberships

Sep, 2016 - Present

評議員, 日本体力医学会

Teaching Experience

Social Activities

運動の効果を最大限に引き出すコツ

Lecturer

順天堂大学スポーツ健康科学部, ミニオープンキャンパス模擬授業, Jul 17, 2021
過去・現在と未来をつなぐマッスルメモリー～これまでの運動経験は将来どのように活かされるのか？～

Lecturer

順天堂大学スポーツ健康科学部, Mar 6, 2021
ロコモ予防のための運動と栄養～効率的な筋活を支える栄養について～

Lecturer

順天堂大学運動生理学研究室, Oct 17, 2020
順天堂大学公開講座”運動の大切さを知ろう!～3世代で一緒に学べるスポーツ科学～

Lecturer

順天堂大学, 順天堂大学公開講座, Jul, 2017
東急グランクレール美しが丘ロコモティブシンドローム予防プロジェクト「体力測定会」結果説明会

Lecturer

東急グランクレール美しが丘, ロコモティブシンドローム予防プロジェクト「体力測定会」結果説明会, May, 2017
東急グランクレール藤ヶ丘・あざみ野ロコモティブシンドローム予防プロジェクト「体力測定会」結果説明会

Lecturer

東急グランクレール藤ヶ丘・あざみ野, ロコモティブシンドローム予防プロジェクト「体力測定会」結果説明会, Apr, 2017
スポーツ・レクリエーション生理学

Lecturer

公益財団法人日本レクリエーション協会, 平成28年度地域スポーツ支援研修会, Feb, 2017
東急グランクレール青葉台ロコモティブシンドローム予防プロジェクト「体力測定会」結果説明会

Lecturer

東急グランクレール青葉台, ロコモティブシンドローム予防プロジェクト「体力測定会」結果説明会, Dec, 2016
親子でロコモチェック

Logistic support

柏市, スポーツドリームかしわ2016, Nov, 2016
運動と栄養順天堂大学オリジナルのロコモ対策を知る!

Lecturer

順天堂大学, 順天堂大学公開講座, Nov, 2016
東急グランクレール美しが丘ロコモティブシンドローム予防プロジェクト「体力測定会」結果説明会

Lecturer

東急グランクレール美しが丘, ロコモティブシンドローム予防プロジェクト「体力測定会」結果説明会, Oct, 2016
順天堂大学公開講座”順天堂大学オリジナルのロコモ対策を学ぼう!今日からできるロコモ対策”

Lecturer

順天堂大学, 順天堂大学公開講座, Oct, 2016
順天堂大学ロコモ度チェック

Logistic support

千葉県, 県民の日ちばわくわくフェスタ2016, Jun, 2016
順天堂大学公開講座”順大オリジナルウォーキングで今日からできるロコモ対策”

Lecturer

順天堂大学, 順天堂大学公開講座, Jan, 2016
順天堂大学スポーツ健康科学部公開講座”筋力アップで生涯を幸福に”

Lecturer

順天堂大学, 順天堂大学公開講座, Nov, 2015

Media Coverage

How can we use our exercise experience when we were young?

Juntendo University, FEATURE, 2019, Dec 25, 2019 Internet
INTERVIEW with JSPS FELLOW in the U.S.

JSPS SAN FRANCISCO, NEWSLETTER, Vol. 49, 8-10, Jul 1, 2019 Newspaper, magazine

Professional Memberships

May, 2023 - Present

European College of Sport Science
Sep, 2020 - Present

American Physiological Society
May, 2009 - Present

THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE
国際スポートロジー学会
Japanese Research Association of Health, Fitness and Nutrition
日本運動生理学会

Profile Information

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Misc.

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