講演・口頭発表等

国際会議
2019年8月21日

Relation of the DGKH genotype with openness to experience, a premorbid personality trait of bipolar disorder

World Congress of Psychiatry 2019
  • Y. Matsumoto
  • ,
  • A. Suzuki
  • ,
  • T. Shirata
  • ,
  • N. Takahashi
  • ,
  • K. Noto
  • ,
  • K. Goto
  • ,
  • K. Otani

記述言語
英語
会議種別
ポスター発表
主催者
World Psychiatry Association
開催地
lispon, portugal

Objectives:
To examine the relation of the diacylglycerol kinase η gene (DGKH) genotype with openness to experience, a premorbid personality trait of bipolar disorder.
Background:
The DGKH is a risk gene for bipolar disorder. Meanwhile, openness to experience, a dimension of the five-factor model of personality, is suggested as a premorbid personality trait of this disorder. In the present study, we examined the relation of the DGKH genotype with openness to experience, to obtain further evidence for the implication of the DGKH in bipolar disorder.
Materials and Methods:
The subjects were 319 healthy Japanese. Openness to experience, as well as other dimensions of the five-factor model, was assessed by the NEO Personality Inventory-Revised. The A/G polymorphism of DGKH (rs9525580) was determined by a PCR-RFLP method. The subjects were divided into two groups with respect to the presence or absence of the A allele, which is a risk allele for bipolar disorder. The Ethics Committee of Yamagata University School of Medicine approved the study protocol, and all subjects provided written informed consent to participate.
Results and Conclusions:
Scores of openness to experience were higher in the group with the A allele than in that without this allele. Meanwhile, the DGKH genotype was not associated with other personality dimensions. The present study suggests that a bipolar-risk allele of DGKH is associated with higher openness to experience, providing further evidence for the implication of this gene in the etiology of bipolar disorder.