yoshihiro kubo

Profile Information

Affiliation: -

J-GLOBAL ID: 200901073217393030
researchmap Member ID: 1000317089

Research Interests

Research Areas

Research History

2003 - Present

Department of Molecular & Cellular Physiology, Division of Biophysics & Neurobiology, National Institute for Physiological Sciences
2000 - 2003

Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
1997 - 2000

副参事研究員, 東京都神経科学総合研究所
1993 - 1997

主任研究員, 東京都神経科学総合研究所
1991 - 1993

University of California, San Francisco
1989 - 1991

主任研究員, 東京都神経科学総合研究所

Papers

132

Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist.

Chang Liu, I-Shan Chen, Michihiro Tateyama, Yoshihiro Kubo

The Journal of biological chemistry, 107219-107219, Mar 22, 2024
A self-inactivating invertebrate opsin optically drives biased signaling toward Gβγ-dependent ion channel modulation.

Hisao Tsukamoto, Yoshihiro Kubo

Proceedings of the National Academy of Sciences of the United States of America, 120(21) e2301269120, May 23, 2023
Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels.

Takushi Shimomura, Kiichi Hirazawa, Yoshihiro Kubo

Proceedings of the National Academy of Sciences of the United States of America, 120(6) e2209569120, Feb 7, 2023
Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific.

Niklas Brake, Adamo S Mancino, Yuhao Yan, Takushi Shimomura, Yoshihiro Kubo, Anmar Khadra, Derek Bowie

The Journal of general physiology, 154(7), Jul 4, 2022
A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel.

I-Shan Chen, Jodene Eldstrom, David Fedida, Yoshihiro Kubo

The Journal of physiology, 600(3) 603-622, Dec 8, 2021
Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 3.

Kiichi Hirazawa, Michihiro Tateyama, Yoshihiro Kubo, Takushi Shimomura

The Journal of biological chemistry, 297(6) 101425-101425, Dec, 2021
Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization.

Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa …

BMC molecular and cell biology, 22(1) 3-3, Jan 7, 2021
K+チャネルのしくみ GIRKチャネルの、小分子による新規機能調節機構

陳以珊, 久保義弘

心電図, 40(2) 107-113, Aug, 2020
A new world of heme function.

Yoshihiro Kubo

Pflugers Archiv : European journal of physiology, 472(5) 547-548, May, 2020
Biophysical research in Okazaki, Japan.

Shuji Akiyama, Kazuhiro Aoki, Yoshihiro Kubo

Biophysical reviews, 12(2) 237-243, Apr, 2020
Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels.

I-Shan Chen, Chang Liu, Michihiro Tateyama, Izhar Karbat, Motonari Uesugi, Eitan Reuveny, Yoshihiro Kubo

British journal of pharmacology, 176(17) 3161-3179, Sep, 2019 Peer-reviewed
Phosphoinositides modulate the voltage dependence of two-pore channel 3.

Takushi Shimomura, Yoshihiro Kubo

The Journal of general physiology, 151(8) 986-1006, Aug 5, 2019 Peer-reviewed
Functional properties of axolotl transient receptor potential ankyrin 1 revealed by the heterologous expression system.

Mai Oda, Hajime Ogino, Yoshihiro Kubo, Osamu Saitoh

Neuroreport, 30(5) 323-330, Mar 20, 2019 Peer-reviewed
Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7.

Jun Ishii, Atsushi Suzuki, Toru Kimura, Michihiro Tateyama, Tatsushi Tanaka, Takuya Yazawa, Yu Arimasu, I-Shan Chen, Kohei Aoyama, Yoshihiro Kubo …

Communications biology, 2(1) 270-270, 2019 Peer-reviewed
Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain.

Shinichiro Kume, Takushi Shimomura, Michihiro Tateyama, Yoshihiro Kubo

The Journal of physiology, 596(19) 4629-4650, Oct, 2018 Peer-reviewed
Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.

I-Shan Chen, Yoshihiro Kubo

The Journal of physiology, 596(10) 1833-1845, May 15, 2018 Peer-reviewed
Structural properties determining low K+ affinity of the selectivity filter in the TWIK1 K+ channel.

Hisao Tsukamoto, Masahiro Higashi, Hideyoshi Motoki, Hiroki Watanabe, Christian Ganser, Koichi Nakajo, Yoshihiro Kubo, Takayuki Uchihashi, Yuji Furutani

The Journal of biological chemistry, 293(18) 6969-6984, May 4, 2018 Peer-reviewed
Sensitivity of Takifugu TRPA1 to thermal stimulations analyzed in oocytes expression system.

Mai Oda, Yoshihiro Kubo, Osamu Saitoh

Neuroreport, 29(4) 280-285, Mar 7, 2018 Peer-reviewed
Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation.

Michihiro Tateyama, Yoshihiro Kubo

PloS one, 13(9) e0204447, 2018 Peer-reviewed
SLO potassium channels antagonize premature decision making in C. elegans.

Ichiro Aoki, Michihiro Tateyama, Takushi Shimomura, Kunio Ihara, Yoshihiro Kubo, Shunji Nakano, Ikue Mori

Communications biology, 1 123-123, 2018 Peer-reviewed

Misc.

Inhibitory Mechanisms of G-protein-gated Inwardly Rectifying K+ Channel by Antihistamines

I-Shan Chen, Chang Liu, Michihiro Tateyama, Izhar Karbat, Motonari Uesugi, Eitan Reuveny, Yoshihiro Kubo

BIOPHYSICAL JOURNAL, 118(3) 117A-117A, Feb, 2020
Homozygous loss-of-function mutation in the SLC26A7 gene coding a novel iodide transporter causes goitrous congenital hypothyroidism

Atsushi Suzuki, Jun Ishii, Aya Yoshida, Naoya Yamguchi, Tatsushi Tanaka, Kohei Aoyama, Michihiro Tateyama, I-Shan Chen, Yoshihiro Kubo, Toru Kimura …

HORMONE RESEARCH IN PAEDIATRICS, 91 36-36, Sep, 2019
Effects and Activation Mechanisms of Ivermectin on G-Protein-Gated Inwardly Rectifying Potassium Channels

I-Shan Chen, Michihiro Tateyama, Yuko Fukata, Motonari Uesugi, Yoshihiro Kubo

BIOPHYSICAL JOURNAL, 114(3) 301A-301A, Feb, 2018
Functional analysis of TRPA1 of zebrafish and pufferfish

Osamu Saitoh, Mai Oda, Mako Kurogi, Yoshihiro Kubo

GENES & GENETIC SYSTEMS, 89(6) 297-297, Dec, 2014
チャネル病

中條浩一, 久保義弘

Dec, 2014 Peer-reviewedInvited
Dynamic aspects of the function and stoichiometry of KCNQ1/KCNE1 ion channel complex

Y. Kubo, K. Nakajo

ACTA PHYSIOLOGICA, 211 43-43, Aug, 2014
Signal Transmission within the Trimeric P2X2 Receptor upon Voltage-and [ATP]-Dependent Gating

Batu Keceli, Yoshihiro Kubo

BIOPHYSICAL JOURNAL, 106(2) 153A-153A, Jan, 2014
A Pair of Phenylalanine Residues on the S4 and S5 Segments Create a Physical and Energy Barrier for the Voltage Sensor in KCNQ1/KCNE1 Channel

Koichi Nakajo, Yoshihiro Kubo

BIOPHYSICAL JOURNAL, 106(2) 140A-140A, Jan, 2014
ゲート

中條浩一, 久保義弘

脳科学辞典, Aug, 2013 Peer-reviewedInvited
イオンチャネル

中條浩一, 久保義弘

脳科学辞典, Aug, 2013 Peer-reviewedInvited
イオン選択性フィルター

中條浩一, 久保義弘

脳科学辞典, Aug, 2013 Peer-reviewedInvited
Gating modulation of KCNQ channels via the voltage -sensing domains

Koichi Nakajo, Yoshihiro Kubo

JOURNAL OF PHYSIOLOGICAL SCIENCES, 63 S54-S54, 2013
Subunit stoichiometry and signal flow analyses in the P2X(2) trimer upon voltage- and [ATP] -dependent activation

Batu Keceli, Yoshihiro Kubo

JOURNAL OF PHYSIOLOGICAL SCIENCES, 63 S247-S247, 2013
Binding of the Gq protein stabilizes the active conformation of the M1R and M3R, but not of P2Y1R

Michihiro Tateyama, Yoshihiro Kubo

JOURNAL OF PHYSIOLOGICAL SCIENCES, 63 S190-S190, 2013
AMAP受容体機能の起源を求めて

平井志伸, 堀田耕司, 久保義弘, 西野敦雄, 岡村康司, 岡浩太朗, 岡戸晴生

日本分子生物学会年会プログラム・要旨集(Web), 36th 3P-0571 (WEB ONLY), 2013
正常における抑制性シナプスの構造と機能 GABA_B受容体の構造と機能

立山充博, 松下真一, 久保義弘

Clin Neurosci, 30(12) 1349-1351, Dec 1, 2012
3PT168 Trials of large amount expression of mammalian potassium ion channels using cultured mammalian cells for biophysical analyses(The 50th Annual Meeting of the Biophysical Society of Japan)

Tsukaoto Hisao, Nakajo Koichi, Kubo Yoshihiro, Furutani Yuji

Seibutsu Butsuri, 52 S170, 2012
原索動物を用いた発生期におけるAMAP受容体の新機能の探索

平井志伸, 堀田耕司, 西野敦雄, 三輪昭子, 高橋弘樹, 岡浩太朗, 岡部繁男, 久保義弘, 岡村康司, 岡戸晴生

日本分子生物学会年会プログラム・要旨集(Web), 35th 3P-0644 (WEB ONLY), 2012
Opsin 5 as a deep brain photoreceptor regulating photoperiodism

Yusuke Nakane, Keisuke Ikegami, Hiroko Ono, Naoyuki Yamamoto, Shosei Yoshida, Yasuhiro Kamei, Sho-ichi Higashi, Kanjun Hirunagi, Shizufumi Ebihara, Yoshihiro Kubo …

NEUROSCIENCE RESEARCH, 71 E171-E171, 2011
FRET analyses of the interaction between m1 muscarinic receptor and Gq proteins

Michihiro Tateyama, Yoshihiro Kubo

NEUROSCIENCE RESEARCH, 71 E86-E86, 2011

Research Projects

チャネルにおけるイオン透過と非典型的膜電位依存性ゲーティングのカップリングの検証

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2023 - Mar, 2026

久保義弘, 陳以珊
イオンチャネルの動的構造変化の蛍光非天然アミノ酸・遷移金属イオン間FRET解析

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

久保義弘
Analysis of dynamic structural rearrangements of functioning ion channels by fluorescent unnatural amino acid

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

KUBO YOSHIHIRO
Analyses of structural rearrangements of membrane proteins by fluorescent unnatural amino acid scanning

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

KUBO Yoshihiro, Tsari Andriani Rizki
Analyses of an orphan metabotropic receptor which plays a role in the long term retention of memory, and a secretory protein encoded by its splice variant

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

KUBO Yoshihiro, YAMAMOTO Izumi, WATANABE Masahiro, Chen I-Shan, Yamamoto Tomomi, TATEYAMA Michihiro, TAKAO Keizo, MIYAKAWA Tsuyoshi, HATTORI Satoko, FUKATA Masaki, FUKATA Yuko, YOKOI Norihiko, SAKIMURA Kenji, SYUU Rei, NATSUME Rie
Comprehensive Brain Science Network

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2016

Kimura Minoru, Tanji Jun, Takada Masahiko, Nakamura Katsuki, Ohtsuka Toshihisa, Aoki Shigeki, Takao Hidemasa, Shimoji Keigo, Goto Masami, Yoshiura Takashi, Nakata Yasuhiro, Abe Osamu, Masumoto Tomohiko, Tokumaru Aya, Matsumura Akira, Kirino Eiji, Terada Hitoshi, Sato Noriko, Kasai Kiyoto, Hashimoto Ryota, Niwa Shin-ichi, Kato Tadafumi, Suzuki Michio, Shuji Iritani, Nemoto Kiyotaka, Tomita Hiroaki, Murayama Shigeo, Akatsu Hiroyasu, Takao Masaki, Saito Yuko, Bito Haruhiko, Yoshimura Yumiko, Matsuzaki Masanori, Furuta Toshiaki, Okado Haruo, Saito Izumu, Kaibuchi Kozo, Hasegawa Masato, Aiba Atsu, Shiina Nobuyuki, Igarashi Michihiro, Tomoki Nishioka, Watanabe Masahiko, Koike Masato, Sakagami Hiroyuki, Shigemoto Ryuichi, Fukazawa Yugo, Sakimura Kenji, Mori Hisashi, Mishina Masayoshi, Kobayashi Kazuto, Yanagawa Yuchio, Uemura Tadashi, Ishihara Takeshi, Nose Akinao, Iino Yuichi, Miyakawa Tsuyoshi, Takao Keizo, Mushiake Hajime, Katayama Norihiro, Tanaka Tetsu, Inoue Kazuhide, Okabe Shigeo, Kano Masanobu, Fujiyama Fumino, Isa Tadashi, Kageyama Ryoichiro, Fujita Ichiro, Yoshida Akira, Nishikawa Toru, Nukina Nobuyuki, Fukai Tomoki, Iwatsubo Takeshi, Yamamori Tetsuo, Okazawa Hitoshi, Tanaka Keiji, Kakigi Ryusuke, Tsuda Ichiro, Kitazawa Shigeru, Doya Kenji, Takahashi Ryosuke, Ikenaka Kazuhiro, Sobue Gen, Hasegawa Toshikazu, Ota Jun, Saitoe Minoru, Kadomatsu Kenji, Kida Satoshi, Manabe Toshiya, Tomita Taisuke, Iwata Atsushi, Murakami Ikuya, Tsutsui Ken-ichiro, Hanakawa Takashi, Hirai Hirokazu, Mima Tatsuya, Isomura Yoshikazu, Samejima Kazuyuki, Hoshi Eiji, Miyata Mariko, Yuzaki Michisuke, Tanaka Masaki, Fukata Masaki, Suzuki Kyoko, Kuba Hiroshi, Masu Masayuki, Kinoshita Makoto, Sugihara Izumi, Shirane Michiko, Yamamoto Nobuhiko, Nishijo Hisao, Nambu Atsushi, Takumi Toru, Yamashita Toshihide, Sakurai Takeshi, Tamamaki Nobuaki, Hata Yoshio, Harada Akihiro, Ozaki Norio, Sakai Katsuyuki, Kubo Yoshihiro, Nakazawa Takanobu, Tanaka Kenji, Takei Nobuyuki, Hitoshi Seiji, Takahiroa. Kato, Kato Fusao, Shirao Tomoaki, Taira Masato, Okano Hideyuki, Sekino Yuko, Okamoto Yasumasa, KOMATSU Hidehiko, Miyata Takaki, Takahashi Yoshiko, Nishida Shinya, Tominaga Makoto
Functional expression of mammalian ion channels and analysis of the molecular mechanisms

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

FURUTANI Yuji, NAKAJO Koichi, TSUKAMOTO Hisao, KIMURA Tetsunari, KUBO Yoshihiro
Analyses of the function of Prrt3, an orphan family C metabotropic recptor

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

KUBO Yoshihiro
High time resolution FRET analysis of the activation of G protein

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

TATEYAMA Michihiro, KUBO Yoshihiro
Analyses of the signal flow upon activation of ATP receptor channel by tandem repeat constructs

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

KUBO Yoshihiro, KECELI Batu
Molecular mechanisms of the physiologically relevant component of the inward rectifier potassium channels that shows low sensitivity to the channel blockers

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

YANAGI Keiko, KUBO Yoshihiro
TRPA1チャネルのカフェインに対する応答の質的種間差異に基づく活性化機構の解明

科学研究費助成事業, 挑戦的萌芽研究, 日本学術振興会, 2009 - 2010

久保義弘
Quantitative analyses of G protein activation by the single molecule imaging

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

TATEYAMA Michihiro, KUBO Yoshihiro
Analyses of an orphan metabotropic receptor and a secretion protein encoded by the same gene

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

KUBO Yoshihiro
膜電位-細胞長変換素子プレスチンの分子構築と動的構造変化の解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2008 - 2009

久保義弘
膜電位センサーを持たないATP受容体チャネルの膜電位依存性ゲーティングの分子基盤

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2007 - 2008

久保義弘
Molecular identification and functional analysis of a caffeine receptor on the plasma membrane.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2006 - 2007

KUBO Yoshihiro, SAITOH Osamu, TATEYAMA Michihiro
膜電位-細胞長変換素子プレスチンの分子構築と動的構造変化

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

久保義弘
ATP受容体チャネルP2Xの発現状況に依存する構造と機能の変化の解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

久保義弘
イオンチヤネル・受容体群の「膜上直接相互作用」によるシナプス伝達の調節機構

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2005 - 2005

久保義弘

Profile Information

Research Interests

Research Areas

Research History

Papers

Misc.

Research Projects

Menu

Coauthors