2012年4月
Suppression of feline coronavirus replication in vitro by cyclosporin A
VETERINARY RESEARCH
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- 巻
- 43
- 号
- 開始ページ
- 41
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1186/1297-9716-43-41
- 出版者・発行元
- BIOMED CENTRAL LTD
The feline infectious peritonitis virus (FIPV) is a member of the feline coronavirus family that causes FIP, which is incurable and fatal in cats. Cyclosporin A (CsA), an immunosuppressive agent that targets the nuclear factor pathway of activated T-cells (NF-AT) to bind cellular cyclophilins (CyP), dose-dependently inhibited FIPV replication in vitro. FK506 (an immunosuppressor of the pathway that binds cellular FK506-binding protein (FKBP) but not CyP) did not affect FIPV replication. Neither cell growth nor viability changed in the presence of either CsA or FK506, and these factors did not affect the NF-AT pathway in fcwf-4 cells. Therefore, CsA does not seem to exert inhibitory effects via the NF-AT pathway. In conclusion, CsA inhibited FIPV replication in vitro and further studies are needed to verify the practical value of CsA as an anti-FIPV treatment in vivo.
- リンク情報
- ID情報
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- DOI : 10.1186/1297-9716-43-41
- ISSN : 0928-4249
- eISSN : 1297-9716
- PubMed ID : 22546085
- Web of Science ID : WOS:000306645700001