論文

査読有り
2017年4月

MicroRNA expression profiling in canine prostate cancer

JOURNAL OF VETERINARY MEDICAL SCIENCE
  • Masanori Kobayashi
  • ,
  • Akiko Saito
  • ,
  • Yoshikazu Tanaka
  • ,
  • Masaki Michishita
  • ,
  • Masato Kobayashi
  • ,
  • Mami Irimajiri
  • ,
  • Takeharu Kaneda
  • ,
  • Kazuhiko Ochiai
  • ,
  • Makoto Bonkobara
  • ,
  • Kimimasa Takahashi
  • ,
  • Tatsuya Hori
  • ,
  • Eiichi Kawakami

79
4
開始ページ
719
終了ページ
725
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1292/jvms.16-0279
出版者・発行元
JAPAN SOC VET SCI

Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are altered in cPCa tissue. The expression levels of 277 mature miRs in prostatic tissue (n=5, respectively) were compared between the non-tumor and tumor groups using real-time PCR. Five miRs (miR-18a, 95, 221, 222 and 330) were up-regulated, but 14 miRs (miR-127, 148a, 205, 299, 329b, 335, 376a, 376c, 379, 380, 381, 411, 487b and 495) were down-regulated specifically in cPCa (P<0.05). These miRs have potential use as early diagnosis markers for cPCa and in miR-based therapy.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1292/jvms.16-0279
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28239051
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000406225100005&DestApp=WOS_CPL