論文

査読有り 国際誌
2020年8月4日

Temozolomide and etoposide combination for the treatment of relapsed osteosarcoma.

Japanese journal of clinical oncology
  • Ryo Akazawa
  • Katsutsugu Umeda
  • Satoshi Saida
  • Itaru Kato
  • Hidefumi Hiramatsu
  • Akio Sakamoto
  • Yoshiki Arakawa
  • Shinji Sumiyoshi
  • Takeshi Okamoto
  • Hiroshi Moritake
  • Souichi Adachi
  • Junko Takita
  • 全て表示

50
8
開始ページ
948
終了ページ
952
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/jjco/hyaa070
出版者・発行元
OXFORD UNIV PRESS

The prognosis of patients with relapsed osteosarcoma is extremely poor and the optimal treatment remains to be identified. Here, we retrospectively analysed the clinical outcomes of nine patients with relapsed osteosarcoma treated with temozolomide/etoposide. Of the two patients who received temozolomide/etoposide as palliative therapy for unresectable tumours, one remained alive with stable disease for >4 years. The remaining seven patients received temozolomide/etoposide as adjuvant therapy following resection of relapsed metastatic disease; of these, one was free from disease for 41 months. Potentially beneficial effects were observed in two of three O6-methylguanine-DNA methyltransferase protein-negative patients, whereas all five O6-methylguanine-DNA methyltransferase-positive patients experienced subsequent relapse. None of the patients experienced severe adverse effects requiring hospitalization. Temozolomide/etoposide is a feasible candidate as salvage therapy for relapsed osteosarcoma. Further studies are needed to verify the utility of O6-methylguanine-DNA methyltransferase protein expression as a biomarker for predicting the response to this treatment.

リンク情報
DOI
https://doi.org/10.1093/jjco/hyaa070
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32463097
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000593052300016&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/jjco/hyaa070
  • ISSN : 0368-2811
  • eISSN : 1465-3621
  • PubMed ID : 32463097
  • Web of Science ID : WOS:000593052300016

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