Yoshiki Ikeda

Profile Information

Affiliation: Institute of Biomedical Science, Kansai Medical University

Degree: 理学(名古屋大学)

J-GLOBAL ID: 201801002171353204
researchmap Member ID: B000330757

Research Areas

Life sciences / Pharmaceuticals - chemistry and drug development /

Awards

Mar, 2022

Outstanding Researcher evaluates, Kansai Medical University

Yoshiki Ikeda

Papers

The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity.

Koh Takeuchi, Yoshiki Ikeda, Miki Senda, Ayaka Harada, Koji Okuwaki, Kaori Fukuzawa, So Nakagawa, Hong Yang Yu, Lisa Nagase, Misaki Imai, Mika Sasaki, Yu-Hua Lo, Doshun Ito, Natsuki Osaka, Yuki Fujii, Atsuo T Sasaki, Toshiya Senda

Structure (London, England : 1993), 30(6) 886-899, Jun 2, 2022
SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides

Yoshiki Ikeda, Akiyoshi Hirayama, Satoshi Kofuji, Yoshihisa Hirota, Ryo Kamata, Natsuki Osaka, Yuki Fujii, Mika Sasaki, Satsuki Ikeda, Eric P Smith, Robert Bachoo, Tomoyoshi Soga, Atsuo T Sasaki

The Journal of Biochemistry, Jul 9, 2021 Peer-reviewedLead author
Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification

Natsuki Osaka, Yoshihisa Hirota, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Venkat R. Chirasani, Sharon L. Campbell, Koh Takeuchi, Toshiya Senda, Atsuo T. Sasaki

Frontiers in Molecular Biosciences, 8, Jul 8, 2021 Peer-reviewed
Effect of Learning Dataset for Identification of Active Molecules: A Case Study of Integrin αIIbβ3 Inhibitors.

Kentaro Kawai, Mami Tomonou, Yume Machida, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Yoshiki Ikeda, Tatsuo Kinashi, Masaaki Omote

Molecular informatics, Mar 18, 2021 Peer-reviewed
Female dominance of both spatial cognitive dysfunction and neuropsychiatric symptoms in a mouse model of Alzheimer’s disease

Masanori A. Murayama, Nagisa Arimitsu, Jun Shimizu, Naruyoshi Fujiwara, Kenji Takai, Yoshiki Ikeda, Yoko Okada, Chieko Hirotsu, Erika Takada, Tomoko Suzuki, Noboru Suzuki

Experimental Animals, 70(3) 398-405, 2021 Peer-reviewed
IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma.

Satoshi Kofuji, Akiyoshi Hirayama, Alexander Otto Eberhardt, Risa Kawaguchi, Yuki Sugiura, Oltea Sampetrean, Yoshiki Ikeda, Mikako Warren, Naoya Sakamoto, Shuji Kitahara, Hirofumi Yoshino, Daisuke Yamashita, Kazutaka Sumita, Kara Wolfe, Lisa Lange, Satsuki Ikeda, Hiroko Shimada, Noriaki Minami, Akshiv Malhotra, Shin Morioka, Yuki Ban, Maya Asano, Victoria L Flanary, Annmarie Ramkissoon, Lionel M L Chow, Juri Kiyokawa, Tomoyuki Mashimo, Greg Lucey, Sergey Mareninov, Tatsuya Ozawa, Nobuyuki Onishi, Koichi Okumura, Jumpei Terakawa, Takiko Daikoku, Trisha Wise-Draper, Nazanin Majd, Kaori Kofuji, Mika Sasaki, Masaru Mori, Yonehiro Kanemura, Eric P Smith, Dimitrios Anastasiou, Hiroaki Wakimoto, Eric C Holland, William H Yong, Craig Horbinski, Ichiro Nakano, Ralph J DeBerardinis, Robert M Bachoo, Paul S Mischel, Wataru Yasui, Makoto Suematsu, Hideyuki Saya, Tomoyoshi Soga, Ingrid Grummt, Holger Bierhoff, Atsuo T Sasaki

Nature cell biology, 21(8) 1003-1014, Aug, 2019 Peer-reviewed
Identification of lysine methylation in the core GTPase domain by GoMADScan.

Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT

PloS one, 14(8) e0219436-e0219436, 2019 Peer-reviewed
多角的解析からみえてくるGTPの新たな機能と人疾患への治療戦略時系列マルチオミクス解析によるGTP代謝とがん化をつなぐ制御メカニズムの解明

河口理紗, デホーン・ミヒル, 池田幸樹, 小藤智史, 平山明由, 森大, 曽我朋義, 竹内恒, 千田俊哉, 佐々木敦朗, 木立尚孝

生命科学系学会合同年次大会, 2017年度 [4PW07-2], Dec, 2017
An archaeal RNA binding protein, FAU-1, is a novel ribonuclease related to rRNA stability in Pyrococcus and Thermococcus

Yoshiki Ikeda, Yasuhiro Okada, Asako Sato, Tamotsu Kanai, Masaru Tomita, Haruyuki Atomi, Akio Kanai

SCIENTIFIC REPORTS, 7(1) 12674, Oct, 2017 Peer-reviewed
【がん代謝ワールブルグを超えて全容解明に挑むトリガーとなる分子、腸内細菌や免疫細胞の関与、標的治療の展望】(第2章)がん特異的な代謝 GTP代謝

小藤智史, 池田幸樹, Wolfe Kara, Randhawa Jaskirat, 河口理紗, 島田裕子, 小藤香織, 佐々木美加, 奥村晃市, 竹内恒, 千田俊哉, 佐々木敦朗

実験医学, 35(10) 1633-1641, Jun, 2017
Structural reverse genetics study of the PI5P4K beta-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells

Koh Takeuchi, Miki Senda, Yu-Hua Lo, Satoshi Kofuji, Yoshiki Ikeda, Atsuo T. Sasaki, Toshiya Senda

FEBS JOURNAL, 283(19) 3556-3562, Oct, 2016 Peer-reviewed
The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis

Kazutaka Sumita, Yu-Hua Lo, Koh Takeuchi, Miki Senda, Satoshi Kofuji, Yoshiki Ikeda, Jumpei Terakawa, Mika Sasaki, Hirofumi Yoshino, Nazanin Majd, Yuxiang Zheng, Emily Rose Kahoud, Takehiro Yokota, Brooke M. Emerling, John M. Asara, Tetsuo Ishida, Jason W. Locasale, Takiko Daikoku, Dimitrios Anastasiou, Toshiya Senda, Atsuo T. Sasaki

Molecular Cell, 61(2) 187-198, Jan 21, 2016 Peer-reviewed
The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis

Kazutaka Sumita, Yu-Hua Lo, Koh Takeuchi, Miki Senda, Satoshi Kofuji, Yoshiki Ikeda, Jumpei Terakawa, Mika Sasaki, Hirofumi Yoshino, Nazanin Majd, Yuxiang Zheng, Emily Rose Kahoud, Takehiro Yokota, Brooke M. Emerling, John M. Asara, Tetsuo Ishida, Jason W. Locasale, Takiko Daikoku, Dimitrios Anastasiou, Toshiya Senda, Atsuo T. Sasaki

MOLECULAR CELL, 61(2) 187-198, Jan, 2016 Peer-reviewed
SSK1, a novel GTP-dependent kinase, detects GTP levels and regulates tumorigenesis

K. Sumita, K. Takeuchi, Y. Lo, M. Senda, S. Kofuji, Y. Ikeda, H. Yoshino, M. Sasaki, J. Terakawa, T. Daikoku, L. C. Cantley, T. Senda, A. T. Sasaki

MOLECULAR BIOLOGY OF THE CELL, 26, 2015 Peer-reviewed
Hfq binding at RhlB-recognition region of RNase E is crucial for the rapid degradation of target mRNAs mediated by sRNAs in Escherichia coli

Yoshiki Ikeda, Mieko Yagi, Teppei Morita, Hiroji Aiba

MOLECULAR MICROBIOLOGY, 79(2) 419-432, Jan, 2011 Peer-reviewed

Misc.

Molecular evolution of PI5P4Kβ that underlies the GTP resilience

竹内恒, 池田幸樹, 千田美紀, 原田彩佳, 奥脇弘次, 福澤薫, 中川草, 長瀬里沙, 今井美咲, 廣田佳久, 佐々木敦朗, 千田俊哉

日本分子生物学会年会プログラム・要旨集(Web), 44th, 2021
Drug discovery strategy for transmembrane proteins from the perspective of integrin drug discovery

Yoshiki Ikeda, Tatsuo Kinashi

SAR News, 39 17-23, Oct, 2020 Peer-reviewedInvitedLead authorCorresponding author
がん特異的な代謝 7.GTP代謝

小藤智史, 小藤智史, 池田幸樹, WOLFE Kara, RANDHAWA Jaskirat, 河口理紗, 河口理紗, 島田裕子, 小藤香織, 佐々木美加, 奥村晃市, 奥村晃市, 竹内恒, 千田俊哉, 佐々木敦朗

実験医学, 35(10) 1633‐1641, Jun 15, 2017
GTP metabolic switch promotes malignant growth of brain tumors

S. Kofuji, M. Warren, K. Sumita, A. Ramkissoon, M. Sasaki, N. Majd, H. Yoshino, K. Kofuji, K. Okumura, Y. Ikeda, R. Rao, L. Chow, A. T. Sasaki

MOLECULAR BIOLOGY OF THE CELL, 26, 2015
ArchaeaにおけるRNA binding proteinであるFAU‐1はRibosomal RNAのprocessingに関わる新規RNaseである

IKEDA YOSHIKI, OKADA YASUHIRO, SATO ASAKO, KANAI TAMOTSU, TOMITA MASARU, ATOMI HARUYUKI, KANAI AKIO

日本分子生物学会年会プログラム・要旨集(Web), 37th 1P-0285 (WEB ONLY), 2014

Books and Other Publications

実験医学増刊 Vol.35 No.10 がん代謝ワールブルグを超えて全容解明に挑む

(Role: Joint author, 第2章がん特異的な代謝 7. GTP代謝)

羊土社, Jun, 2017
大腸菌におけるRNase EとRNA結合タンパク質Hfq間の相互作用領域の解析

池田幸樹

名古屋大学, Feb, 2011

Presentations

Toward establishment for in silico-oriented Science

Yoshiki Ikeda

Dec 16, 2021 Invited
インテグリン関連疾患治療薬開発に向けた薬剤スクリーニング法の開発

池田幸樹

スクリーニング学研究会, Nov 22, 2019
アカデミア創薬・インテグリン創薬コンソーシアム事業から学ぶアカデミア創薬研究の流れ

池田幸樹

スクリーニング学研究会, Nov 21, 2019
The physiological role of GTP sensing activity of PI5P4Kβ and its evolutional aspects

Yoshiki Ikeda

The Molecular Biology Society of Japan 2018, Nov 28, 2018 Invited
Structure-based screening to identify inhibitor against GTP-sensor kinase, PI5P4Kβ, for cancer therapy.

Ikeda Y, Takeuchi K, Senda M, Fukunishi Y, Kawaguchi R, Sasaki M, Senda T, Sasaki AT

UC symposia conference 2018, Apr, 2018, University of Cincinnati
Structure-based screening to identify inhibitor against GTP-sensor kinase, PI5P4Kβ, for cancer therapy.

Ikeda Y, Takeuchi K, Senda M, Fukunishi Y, Kawaguchi R, Sasaki M, Senda T, Sasaki AT

Keystone symposia conference 2018, B5: Phosphoinositide Biology: New Therapeutic Targets Beyond Class I PI3K, Feb, 2018
PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis.

Ikeda Y, Takeuchi K, Senda M, Nakagawa S, Harada A, Fukunishi Y, Kawaguchi R, Sasaki M, Senda T, Sasaki AT

Keystone symposia conference 2018, B5: Phosphoinositide Biology: New Therapeutic Targets Beyond Class I PI3K, Feb, 2018 Invited
Toward making “Tumor-buster” which inhibit GTP-sensor kinase, PI5P4Kβ.

Yoshiki Ikeda

Seminar at Keio University, Jun, 2017 Invited
Reverse-Structural screening to identify inhibitor against GTP-sensor kinase, PI5P4Kβ, for cancer therapy.

Ikeda Y, Takeuchi K, Senda M, Fukunishi Y, Senda T, Sasaki AT

Keystone symposia conference 2017, X3: Tumor Metabolism: Mechanisms and Targets, Mar, 2017
Pharmacological targeting of GTP-energy sensor, PI5P4Kß, as a novel breast cancer therapeutics.

Ikeda Y, Takeuchi K, Senda M, Fukunishi Y, Senda T, Sasaki AT

Jensen symposium 2016, Oct, 2016

Major Research Projects

Development of next-generation-antibodies based on shark VNAR platform

Japan Agency for Medical Research and Development, Jul, 2021 - Mar, 2026

Yoshiki Ikeda
Talin1によるインテグリン活性化を介した神経膠(芽)腫悪性化メカニズムの解明

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

池田幸樹
Discovery and Development of Drugs for Glioblastoma based on Integrin inhibition

Japan Agency for Medical Research and Development, Apr, 2020 - Mar, 2022
大腸菌におけるRNase Eを基盤としたRNA分解複合体の解析

科学研究費助成事業特別研究員奨励費, 日本学術振興会, 2010 - 2011

池田幸樹

Industrial Property Rights

特願P21008JP Therapeutic drug for myasthenia gravis

Humiyuki Hattori, Yoshiki Ikeda
特願2021-055869 Nitrogen-containing compounds, and markers for predicting tumor malignancy

Mikio Hayashi, Yoshiki Ikeda, Ryoichi Iwata

Media Coverage

Research team unravels the trick of evolving the GTP sensor

VERVE TIMES, May, 2022 Internet
US-Japan research team unravels the trick of evolving the GTP sensor

AAAS, EurekAlert, May, 2022 Internet
がん細胞の代謝物利用調べる方法確立創薬や治療戦略などへの応用期待

荘内日報社, 荘内日報, Nov 12, 2021 Newspaper, magazine
がん細胞の代謝経路追跡創薬、治療への応用期待

山形新聞社, 山形新聞, Nov 10, 2021 Newspaper, magazine
Effect of Learning Dataset for Identification of Active Molecules

Med IT Tech, Apr, 2021 Internet

Profile Information

Research Areas

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Papers

Misc.

Books and Other Publications

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Major Research Projects

Industrial Property Rights

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