2015年7月
FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis
DEVELOPMENT
- ,
- 巻
- 142
- 号
- 13
- 開始ページ
- 2329
- 終了ページ
- +
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1242/dev.122408
- 出版者・発行元
- COMPANY OF BIOLOGISTS LTD
When a tubular structure forms during early embryogenesis, tubular elongation and lumen formation (epithelialization) proceed simultaneously in a spatiotemporally coordinated manner. We here demonstrate, using the Wolffian duct (WD) of early chicken embryos, that this coordination is regulated by the expression of FGF8, which shifts posteriorly during body axis elongation. FGF8 acts as a chemoattractant on the leader cells of the elongating WD and prevents them from epithelialization, whereas static ('rear') cells that receive progressively less FGF8 undergo epithelialization to form a lumen. Thus, FGF8 acts as a binary switch that distinguishes tubular elongation from lumen formation. The posteriorly shifting FGF8 is also known to regulate somite segmentation, suggesting that multiple types of tissue morphogenesis are coordinately regulated by macroscopic changes in body growth.
- リンク情報
- ID情報
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- DOI : 10.1242/dev.122408
- ISSN : 0950-1991
- eISSN : 1477-9129
- PubMed ID : 26130757
- Web of Science ID : WOS:000357124900011