Kouichi Yoshinari

J-GLOBAL         Last updated: Nov 14, 2018 at 00:54
 
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Name
Kouichi Yoshinari
Affiliation
University of Shizuoka
Section
School of Pharmaceutical Sciences
Research funding number
60343399

Research Interests

 
 

Research Areas

 
 

Awards & Honors

 
Apr 2011
ISSX Asia-Pacific New Investigator Award, ISSX
 

Published Papers

 
Nagai M, Hosaka T, Satsukawa M, Yoshinari K
Journal of pharmaceutical sciences   107(9) 2479-2488   Sep 2018   [Refereed]
Masuda A, Masuda M, Kawano T, Kitsunai Y, Nakayama H, Nakajima H, Kojima H, Kitamura S, Uramaru N, Hosaka T, Sasaki T, Yoshinari K
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan   137(5) 611-622   2017   [Refereed]
Todoroki K, Kudoh Y, Nakamura M, Shimizu Y, Sasaki T, Otsuki H, Wada K, Min JZ, Mizuno H, Yoshinari K, Toyo'oka T
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   34(9) 1011-1015   Sep 2018   [Refereed]
Sasaki T, Sato Y, Kumagai T, Yoshinari K, Nagata K
Journal of pharmaceutical health care and sciences   3 14   2017   [Refereed]
Nihira K, Nan-Ya KI, Kakuni M, Ono Y, Yoshikawa Y, Ota T, Hiura M, Yoshinari K
Toxicological sciences : an official journal of the Society of Toxicology      Sep 2018   [Refereed]
Liu S, Kawamoto T, Morita O, Yoshinari K, Honda H
Toxicology and Applied Pharmacology   318 79-87   Mar 2017   [Refereed]
Abe T, Amaike Y, Shizu R, Takahashi M, Kano M, Hosaka T, Sasaki T, Kodama S, Matsuzawa A, Yoshinari K
Toxicological sciences : an official journal of the Society of Toxicology      Jun 2018   [Refereed]
Kodama S, Shimura T, Kuribayashi H, Abe T, Yoshinari K
Toxicology Letters   271 58-65   Feb 2017   [Refereed]
Yoshimaru S, Shizu R, Tsuruta S, Amaike Y, Kano M, Hosaka T, Sasaki T, Yoshinari K
The Journal of toxicological sciences   43(7) 443-450   2018   [Refereed]
Shizu R, Abe T, Benoki S, Takahashi M, Kodama S, Miayata M, Matsuzawa A, Yoshinari K
The Biochemical journal   473(3) 257-266   Nov 2015   [Refereed]
Abe T, Takahashi M, Kano M, Amaike Y, Ishii C, Maeda K, Kudoh Y, Morishita T, Hosaka T, Sasaki T, Kodama S, Matsuzawa A, Kojima H, Yoshinari K
Archives of toxicology      Nov 2016   [Refereed]
Sasaki T, Inami K, Numata Y, Funakoshi K, Yoshida M, Kumagai T, Kanno S, Matsui S, Toriyabe T, Yamazoe Y, Yoshinari K, Nagata K
The Journal of pharmacology and experimental therapeutics   359(1) 102-109   Oct 2016   [Refereed]
Yamazoe Y, Ito K, Yamamura Y, Iwama R, Yoshinari K
Drug metabolism and pharmacokinetics   31(5) 363-384   Oct 2016   [Refereed]
Nagai M, Konno Y, Satsukawa M, Yamashita S, Yoshinari K
Drug metabolism and disposition: the biological fate of chemicals   44(8) 1390-1398   Aug 2016   [Refereed]
Yoshinari K, Yamashita K
Drug Metabolism and Pharmacokinetics   31(1) 1-2   Feb 2016   [Refereed]
Fujino C, Tamura Y, Tange S, Nakajima H, Sanoh S, Watanabe Y, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S
The Journal of Toxicological Sciences   41(5) 677-691   2016   [Refereed]
Iwamori S, Sato E, Saigusa D, Yoshinari K, Ito S, Sato H, Takahashi N
American Journal of Physiology. Renal Physiology   309(7) F667-71   Oct 2015   [Refereed]
Miyata M, Hayashi K, Yamakawa H, Yamazoe Y, Yoshinari K
Biological & Pharmaceutical Bulletin   38(3) 493-496   2015   [Refereed]
Miyata M, Hata T, Yamazoe Y, Yoshinari K
Biochemical and biophysical research communications   443(2) 477-482   Jan 2014   [Refereed]

Misc

 
SHIZU Ryota, BENOKI Satoshi, MIYATA Masaaki, KODAMA Susumu, YOSHINARI Kouichi
Annual Meeting of the Japanese Society of Toxicology   40(0)    2013
核内受容体pregnene X receptor (PXR)およびconstitutive androstane receptor (CAR)は,肝に高発現し,生体異物に応答して異物除去など様々な生理機能を制御する転写因子である。CARの活性化はまた,肝細胞増殖や肝発がんと関連しており,このことが化学物質の安全性評価においてしばしば問題となる。最近我々は,PXRの活性化は単独では肝細胞増殖作用を示さないものの,CAR活性化薬や核内受容体PPARα活性化薬による肝細胞増殖を増強することを見出...
SHIMURA Takuto, KODAMA Susumu, KURIBAYASHI Hideaki, MIYATA Masaaki, YOSHINARI Kouichi, YAMAZOE Yasushi
Annual Meeting of the Japanese Society of Toxicology   40(0)    2013
核内受容体pregnane X receptor (PXR)は,肝臓や腸管に高いレベルで発現し,それら臓器の主要な生理機能の調節を担う低分子応答性の転写因子である。近年,PXRの機能喪失や異常と免疫系の活性亢進及び炎症性疾患との関連,またPXRの活性化による炎症軽減作用が報告され,PXRの新規生理機能として免疫系調節への関与が注目されている。しかし,その詳細な作用機序は依然として不明である。そこでコンカナバリンA(Con A)誘発性マウス肝障害モデルを用いて,PXRによる免疫系調節の作用機...
NAKAJIMA Hiroyuki, YOSHINARI Kouichi
Annual Meeting of the Japanese Society of Toxicology   40(0)    2013
化学物質の暴露に伴い,肝細胞肥大とそれによる肝肥大がしばしば認められる。肝細胞肥大の毒性学的意義は明確ではないが,肝がんや他の肝毒性との関連も指摘されており,その発生機序の理解は化学物質の安全性評価に重要である。現在までに肝細胞肥大の発生機序に関する報告はほとんど無いが,薬物代謝酵素誘導に伴い起こることが示唆されている。薬物代謝酵素誘導には異物応答性の転写因子であるAh受容体ならびに核内受容体PXR,CARおよびPPARαが中心的に働くことから,本研究では,化学物質の肝細胞肥大作用とこれら...
YAMADA Takashi, HASEGAWA Ryuichi, SAKURATANI Yuki, YAMADA Jun, YOSHINARI Koichi, YAMAZOE Yasushi, HIROSE Akihiko, HAYASHI Makoto
Annual Meeting of the Japanese Society of Toxicology   40(0)    2013
反復投与毒性試験は,化学物質の有害性評価において重要な役割を果たしており,わが国の化学物質審査規制法(化審法)やEUのREACHなどで化学物質の有害性の判定に用いられている。しかし時間とコストがかかることから試験された物質は限られており,近年の国内外における化学物質管理制度の改正に伴って,既に市場に流通している数多くの未試験物質について安全性評価が求められる。このため動物試験を戦略的に実施する必要があるほか,データギャップ補完のための1つの手法としてカテゴリーアプローチが考えられている。こ...
Ito Kazumi, Yoshinari Koichi, Yamazoe Yasushi
Taikai Program Yoshisyu of the Environmental Mutagen Society of Japan   (41)    Oct 2012

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2011 - 2012    Investigator(s): Kouichi YOSHINARI
In this study, we have investigated the influences of treatment with the activators of inflammation-associated nuclear receptors on the gene expression profile of inflammation-related genes in human model macrophages and rat Kupffer cells. The res...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2010 - 2012    Investigator(s): Kouichi YOSHINARI
In this study, we have investigated the functions of nuclear receptors CAR and PXR to understand their roles in hepatotoxicity. We have found that CAR transactivates human and mouse DHCR24 genes, that CAR inhibits PPARα-mediated transcription in m...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2010 - 2011    Investigator(s): Yasushi YAMAZOE
In this study, we have obtained following findings : 1)the expressions of mouse Cyp3a11 and human CYP3A4 in hepatocytes are modulated by cellular cholesterol levels, 2)SREBP-2 activated by reduced cellular cholesterol levels down-regulates the exp...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2009 - 2011    Investigator(s): Yasushi YAMAZOE
We studied on the bile acid-mediated regulation of ileal FGF15/19 expression and FGF15/19-mediated regulation of hepatic lipid metabolism. The suppression of enterobacteria-mediated bile acid conversion decreased ileal FGF15 levels resulting in th...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2011    Investigator(s): Satoru KAKIZAKI
The roles and crosstalk between nuclear receptors PXR and CAR on the pathogenesis of non-alcoholic steatohepatitis (NASH) were evaluated in this study. CAR accelerated the production of reactive oxygen species (ROS) and worsened the liver injury a...