2018年5月
Selectivity of Ca2+ channel blockers for dilator actions on the isolated lower esophageal sphincter and aorta from rats.
Journal of pharmacological sciences
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- 巻
- 137
- 号
- 1
- 開始ページ
- 98
- 終了ページ
- 100
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jphs.2018.01.012
- 出版者・発行元
- Japanese Pharmacological Society
We compared dilator actions of representative four Ca2+ channel blockers on the isolated lower esophagus sphincter (LES) and thoracic aorta from rats. Verapamil, diltiazem, nifedipine and cilnidipine suppressed KCl-induced contractions of LES and thoracic aorta in a concentration-dependent manner. The order of selectivity for LES, which was calculated as ratio of IC50 value for thoracic aorta divided by that for LES, was diltiazem > verapamil > nifedipine > cilnidipine. These results suggest that diltiazem more preferentially dilates the LES whereas cilnidipine is expected to have lower potential risk of gastroesophageal dysfunction during the antihypertensive therapy.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jphs.2018.01.012
- ISSN : 1347-8648
- ISSN : 1347-8613
- PubMed ID : 29709270
- SCOPUS ID : 85046122423