論文

国際誌
2023年2月16日

Non-A Blood Type Is a Risk Factor for Poor Cardio-Cerebrovascular Outcomes in Patients Undergoing Dialysis.

Biomedicines
  • Takafumi Nakayama
  • Junki Yamamoto
  • Toshikazu Ozeki
  • Yoshiro Tsuruta
  • Masashi Yokoi
  • Tomonori Aoi
  • Yoshiko Mori
  • Mayuko Hori
  • Makoto Tsujita
  • Yuichi Shirasawa
  • Chika Kondo
  • Kaoru Yasuda
  • Minako Murata
  • Yuko Kinoshita
  • Shigeru Suzuki
  • Michio Fukuda
  • Chikao Yamazaki
  • Noriyuki Ikehara
  • Makoto Sugiura
  • Toshihiko Goto
  • Hiroya Hashimoto
  • Kazuhiro Yajima
  • Shoichi Maruyama
  • Kunio Morozumi
  • Yoshihiro Seo
  • 全て表示

11
2
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/biomedicines11020592

The clinical impact of ABO blood type on cardio-cerebrovascular outcomes in patients undergoing dialysis has not been clarified. A total of 365 hemodialysis patients participated in the current study. The primary endpoint was defined as a composite including cardio-cerebrovascular events and cardio-cerebrovascular death. The primary endpoint was observed in 73 patients during a median follow-up period of 1182 days, including 16/149 (11%) with blood type A, 22/81 (27%) with blood type B, 26/99 (26%) with blood type O, and 9/36 (25%) with blood type AB. At baseline, no difference was found in the echocardiographic parameters. Multivariable Cox regression analyses revealed that blood type (type A vs. non-A type; hazard ratio (HR): 0.46, 95% confidence interval (95% CI): 0.26-0.81, p = 0.007), age (per 10-year increase; HR: 1.47, 95% CI: 1.18-1.84), antiplatelet or anticoagulation therapy (HR: 1.91, 95% CI: 1.07-3.41), LVEF (per 10% increase; HR: 0.78, 95% CI: 0.63-0.96), and LV mass index (per 10 g/m2 increase; HR: 1.07, 95% CI: 1.01-1.13) were the independent determinants of the primary endpoint. Kaplan-Meier curves also showed a higher incidence of the primary endpoint in the non-A type than type A (Log-rank p = 0.001). Dialysis patients with blood type A developed cardio-cerebrovascular events more frequently than non-A type patients.

リンク情報
DOI
https://doi.org/10.3390/biomedicines11020592
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/36831128
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953354
ID情報
  • DOI : 10.3390/biomedicines11020592
  • PubMed ID : 36831128
  • PubMed Central 記事ID : PMC9953354

エクスポート
BibTeX RIS