Yoshiya Hosokawa

Profile Information

Affiliation: Center for Infection Disease Education and Research （CiDER）, Osaka University

Degree: 博士（医学）(大阪大学)

J-GLOBAL ID: 201901002823100750
researchmap Member ID: B000364445

Research Areas

Life sciences / Metabolism and endocrinology /

Awards

Papers

Inflammatory Cell Infiltration into Islets without PD-L1 Expression is Associated with the Development of Immune Checkpoint Inhibitor-Related Type 1 Diabetes in Genetically Susceptible Patients.

Satoshi Kawata, Junji Kozawa, Sho Yoneda, Yukari Fujita, Risa Kashiwagi-Takayama, Takekazu Kimura, Yoshiya Hosokawa, Megu Y Baden, Sae Uno, Rikako Uenaka, Kazuyuki Namai, Yoko Koh, Yoshito Tomimaru, Haruhiko Hirata, Motohide Uemura, Satoshi Nojima, Eiichi Morii, Hidetoshi Eguchi, Akihisa Imagawa, Iichiro Shimomura

Diabetes, Jan 19, 2023
Amelioration of pancreatic fat accumulation in Japanese type 2 diabetes patients treated with sodium-glucose cotransporter 2 inhibitors: a retrospective study

Tomomi Horii, Junji Kozawa, Shingo Fujita, Yoshiya Hosokawa, Takekazu Kimura, Yukari Fujita, Ayumi Tokunaga, Kenji Fukui, Iichiro Shimomura

Obesity Science and Practice, 7(3) 346-352, Jun, 2021
Clinical Significance of the Maximum Body Mass Index before Onset of Type 2 Diabetes for Predicting Beta-Cell Function

Harutoshi Ozawa, Kenji Fukui, Sho Komukai, Yoshiya Hosokawa, Yukari Fujita, Takekazu Kimura, Ayumi Tokunaga, Junji Kozawa, Hiromi Iwahashi, Iichiro Shimomura

Journal of the Endocrine Society, 4(4) 1-13, Apr 1, 2020 Peer-reviewed
Pancreatic fat is related to the longitudinal decrease in the increment of C-peptide in glucagon stimulation test in type 2 diabetes patients

Chisaki Ishibashi, Junji Kozawa, Yoshiya Hosokawa, Sho Yoneda, Takekazu Kimura, Yukari Fujita, Kenji Fukui, Hiromi Iwahashi, Iichiro Shimomura

Journal of Diabetes Investigation, 11(1) 80-87, Jan 1, 2020 Peer-reviewed
Transplantation of autologous bone marrow-derived mesenchymal stem cells under arthroscopic surgery with microfracture versus microfracture alone for articular cartilage lesions in the knee: A multicenter prospective randomized control clinical trial

Yusuke Hashimoto, Yohei Nishida, Shinji Takahashi, Hiroaki Nakamura, Hisashi Mera, Kaori Kashiwa, Shinichi Yoshiya, Yusuke Inagaki, Kota Uematsu, Yasuhito Tanaka, Shigeki Asada, Masao Akagi, Kanji Fukuda, Yoshiya Hosokawa, Akira Myoui, Naosuke Kamei, Masakazu Ishikawa, Nobuo Adachi, Mitsuo Ochi, Shigeyuki Wakitani

Regenerative Therapy, 11 106-113, Dec, 2019 Peer-reviewed
Pathogenesis of fulminant type 1 diabetes: Genes, viruses and the immune mechanism, and usefulness of patient-derived induced pluripotent stem cells for future research

Yoshiya Hosokawa, Toshiaki Hanafusa, Akihisa Imagawa

Journal of Diabetes Investigation, 10(5) 1158-1164, Sep 1, 2019 Peer-reviewedInvited
Positive correlation between fasting plasma glucagon and serum C-peptide in Japanese patients with diabetes

Yoshiya Hosokawa, Junji Kozawa, Hitoshi Nishizawa, Dan Kawamori, Norikazu Maeda, Michio Otsuki, Taka aki Matsuoka, Hiromi Iwahashi, Iichiro Shimomura

Heliyon, 5(5) e01715, May, 2019 Peer-reviewed
T-lymphocyte infiltration to islets in the pancreas of a patient who developed type 1 diabetes after administration of immune checkpoint inhibitors

Sho Yoneda, Akihisa Imagawa, Yoshiya Hosokawa, Megu Yamaguchi Baden, Takekazu Kimura, Sae Uno, Kenji Fukui, Kunihito Goto, Motohide Uemura, Hidetoshi Eguchi, Hiromi Iwahashi, Junji Kozawa, Iichiro Shimomura

Diabetes Care, 42(7) E116-E118, Jul, 2019 Peer-reviewed
Insulin-producing cells derived from ‘induced pluripotent stem cells’ of patients with fulminant type 1 diabetes: Vulnerability to cytokine insults and increased expression of apoptosis-related genes

Yoshiya Hosokawa, Taro Toyoda, Kenji Fukui, Megu Yamaguchi Baden, Michinori Funato, Yasushi Kondo, Tomomi Sudo, Hiromi Iwahashi, Marina Kishida, Chihiro Okada, Akira Watanabe, Isao Asaka, Kenji Osafune, Akihisa Imagawa, Iichiro Shimomura

Journal of Diabetes Investigation, 9(3) 481-493, May 1, 2018
Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells

Yasushi Kondo, Taro Toyoda, Ryo Ito, Michinori Funato, Yoshiya Hosokawa, Satoshi Matsui, Tomomi Sudo, Masahiro Nakamura, Chihiro Okada, Xiaotong Zhuang, Akira Watanabe, Akira Ohta, Nobuya Inagaki, Kenji Osafune

Diabetologia, 60(8) 1454-1466, Aug 1, 2017 Peer-reviewed
Examination of a viral infection mimetic model in human iPS cell-derived insulin- producing cells and the anti-apoptotic effect of GLP-1 analogue

Megu Yamaguchi Baden, Kenji Fukui, Yoshiya Hosokawa, Hiromi Iwahashi, Akihisa Imagawa, Iichiro Shimomura

PLoS ONE, 10(12) e0144606, Dec 1, 2015 Peer-reviewed
Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells

Taro Toyoda, Shin Ichi Mae, Hiromi Tanaka, Yasushi Kondo, Michinori Funato, Yoshiya Hosokawa, Tomomi Sudo, Yoshiya Kawaguchi, Kenji Osafune

Stem Cell Research, 14(2) 185-197, Mar 1, 2015 Peer-reviewed
Development of the Method to Differentiate Pancreatic beta-like Cells from Human iPS Cells by Using Small Molecules

Yasushi Kondo, Kentaro Toyoda, Taro Toyoda, Michinori Funato, Yoshiya Hosokawa, Satoshi Matsui, Tomomi Sudo, Xiaotong Zhuang, Akira Ohta, Shinya Yamanaka, Nobuya Inagaki, Kenji Osafune

DIABETES, 63 A543-A543, Jun, 2014
Juxtaglomerular cell tumor that was preoperatively diagnosed using selective renal venous sampling

Saeko Osawa, Yoshiya Hosokawa, Tetsuji Soda, Tetsuyuki Yasuda, Hideaki Kaneto, Tetsuhiro Kitamura, Junji Kozawa, Michio Otsuki, Akihisa Imagawa, Masayoshi Okumi, Yasushi Miyagawa, Norio Nonomura, Iichiro Shimomura

Internal Medicine, 52(17) 1937-1942, 2013 Peer-reviewed
Relationship between serum cystatin C and serum adiponectin level in type 2 diabetic patients

Yoshiya Hosokawa, Yuya Yamada, Yoshinari Obata, Megu Yamaguchi Baden, Kenji Saisho, Arisa Ihara, Koji Yamamoto, Kiyonori Katsuragi, Yuji Matsuzawa

Clinical and Experimental Nephrology, 16(3) 399-405, Jun, 2012 Peer-reviewed
Original article evaluation of diabetic polyneuropathy by Pain Vision ^®PS-2100, the device for quantitative analysis of perception and pain

Megu Yamaguchi Baden, Yoshinari Obata, Yoshiya Hosokawa, Kenji Saisho, Sachiko Tamba, Koji Yamamoto, Yuya Yamada, Yuji Matsuzawa

Journal of the Japan Diabetes Society, 54(7) 493-498, Jul 30, 2011
An autopsy case of left ventricular apical ballooning probably caused by pheochromocytoma with persistent ST-segment elevation

Hiroyasu Ueda, Yoshiya Hosokawa, Ui Tsujii, Masami Miyawaki, Nobuhiro Mitsusada, Yuji Yasuga, Hisatoyo Hiraoka, Shin Ichi Nakatsuka

International Journal of Cardiology, 149(2) e50-e52-E52, Jun 2, 2011
Clinical significance of serum adiponectin in Japanese diabetic patients

Yoshiya Hosokawa, Yuya Yamada, Yoshinari Obata, Megu Yamaguchi Baden, Kenji Saisho, Arisa Ihara, Koji Yamamoto, Kiyonori Katsuragi, Yuji Matsuzawa

Diabetology International, 2(2) 65-71, Jun, 2011
Long-term efficacy of trilostane for Cushing's syndrome due to adrenocorticotropin-independent bilateral macronodular adrenocortical hyperplasia

Yoshinari Obata, Yuya Yamada, Megu Yamaguchi Baden, Yoshiya Hosokawa, Kenji Saisho, Sachiko Tamba, Koji Yamamoto, Yuji Matsuzawa

Internal Medicine, 50(21) 2621-2625, 2011 Peer-reviewed
Long-term suppressive effect of octreotide on progression of metastatic gastrinoma with multiple endocrine neoplasia type 1: Seven-year follow up

Megu Yamaguchi, Yuya Yamada, Yoshiya Hosokawa, Ryuya Iwamoto, Sachiko Tamba, Arisa Ihara, Koji Yamamoto, Yoshihiko Hoshida, Yuji Matsuzawa

Internal Medicine, 49(15) 1557-1563, 2010

Misc.

劇症1型糖尿病発症メカニズムの解明患者由来iPS細胞を用いた検討

細川吉弥, 新川翔也, 古野正浩, 福井健司, 小澤純二, 福崎英一郎, 今川彰久, 下村伊一郎

糖尿病, 64(Suppl.1) 助成-8, May, 2021
劇症1型糖尿病発症メカニズムの解明

細川吉弥

日本応用酵素協会誌, (55) 75-76, Mar, 2021
劇症1型糖尿病発症メカニズムの解明-患者由来iPS細胞を用いた検討-

細川吉弥, 新川翔也, 古野正浩, 福井健司, 小澤純二, 福崎英一郎, 今川彰久, 下村伊一郎

糖尿病(Web), 64(Suppl), 2021
発症早期のインスリン負荷試験にてグルカゴン分泌反応不全を認めた劇症1型糖尿病の一例

細川吉弥, 小澤純二, 川知祐介, 米田祥, 河盛段, 西澤均, 前田法一, 大月道夫, 松岡孝昭, 下村伊一郎

日本内分泌学会雑誌, 96(1) 277-277, Aug, 2020
末期腎不全を合併した若年発症のインスリン依存型糖尿病2例に対する全エクソーム解析

藤田真吾, 宮下洋平, 藤田有可里, 細川吉弥, 木村武量, 徳永あゆみ, 福井健司, 朝野仁裕, 小澤純二, 下村伊一郎

糖尿病, 63(Suppl.1) S-163, Aug, 2020
2型糖尿病患者の発症前既往最高BMIとβ細胞・α細胞量の関連の検討

小澤栄稔, 福井健司, 藤田有可里, 米田祥, 焦裕之, 石橋千咲, 藤田真吾, 細川吉弥, 木村武量, 徳永あゆみ, 江口英利, 小澤純二, 下村伊一郎

糖尿病, 63(Suppl.1) S-197, Aug, 2020
細胞外インスリンによる膵β細胞におけるGLUT2発現に関する検討

焦裕之, 福井健司, 米田祥, 石橋千咲, 藤田有可里, 細川吉弥, 木村武量, 小澤純二, 下村伊一郎

糖尿病, 63(Suppl.1) S-257, Aug, 2020
2型糖尿病患者におけるSGLT2阻害剤の膵脂肪化に対する効果

福井健司, 堀井知美, 石橋千咲, 藤田真吾, 細川吉弥, 木村武量, 藤田有可里, 徳永あゆみ, 小澤純二, 下村伊一郎

糖尿病, 63(Suppl.1) S-295, Aug, 2020
免疫チェックポイント阻害薬による1型糖尿病発症例の膵組織の検討

高山理佐, 藤田有可里, 米田祥, 宇野彩, 川田哲史, 小澤栄稔, 細川吉弥, 木村武量, 福井健司, 小澤純二, 下村伊一郎

糖尿病, 63(Suppl.1) S-315, Aug, 2020
ニボルマブ投与後に糖尿病発症と膵外分泌酵素上昇を呈した透析患者の一例

籠田芳夫, 木村武量, 細川吉弥, 小澤純二, 前田法一, 大月道夫, 松岡孝昭, 下村伊一郎

糖尿病, 63(Suppl.1) S-316, Aug, 2020
末期腎不全を合併した若年発症のインスリン依存型糖尿病2例に対する全エクソーム解析

藤田真吾, 宮下洋平, 藤田有可里, 藤田有可里, 細川吉弥, 木村武量, 徳永あゆみ, 福井健司, 朝野仁裕, 小澤純二, 小澤純二, 下村伊一郎

糖尿病(Web), 63(Suppl), 2020
2型糖尿病患者における膵および肝の脂肪化の臨床的意義

石橋千咲, 小澤純二, 細川吉弥, 米田祥, 木村武量, 藤田有可里, 福井健司, 岩橋博見, 下村伊一郎

糖尿病, 62(Suppl.1) S-150, Apr, 2019
高インスリン血症と反応性低血糖を呈し,全エクソーム解析を行った1例

堀谷恵美, 藤田真吾, 宮下洋平, 黒田陽平, 藤田有可里, 細川吉弥, 木村武量, 徳永あゆみ, 福井健司, 小澤純二, 朝野仁裕, 鎌田佳宏, 嶺尾郁夫, 岩橋博見, 下村伊一郎

糖尿病, 62(Suppl.1) S-157, Apr, 2019
インスリノーマ症例における非腫瘍部膵島のGLUT2ならびにGLP-1受容体発現に関する検討

焦裕之, 米田祥, 福井健司, 豊田新一郎, 石橋千咲, 藤田有可里, 細川吉弥, 木村武量, 小澤純二, 岩橋博見, 下村伊一郎

糖尿病, 62(Suppl.1) S-257, Apr, 2019
日本人2型糖尿病患者において空腹時グルカゴン値は血中Cペプチド値と正相関する

細川吉弥, 小澤純二, 西澤均, 河盛段, 前田法一, 大月道夫, 松岡孝昭, 岩橋博見, 下村伊一郎

糖尿病, 62(Suppl.1) S-278, Apr, 2019
免疫チェックポイント阻害薬投与後発症1型糖尿病患者膵の免疫組織化学的検討

米田祥, 今川彰久, 細川吉弥, 木村武量, 福井健司, 小澤純二, 後藤邦仁, 植村元秀, 江口英利, 岩橋博見, 下村伊一郎

糖尿病, 62(Suppl.1) S-286, Apr, 2019
2型糖尿病患者の発症前最高体重と膵β細胞特性についての組織学的検討

福井健司, 小澤栄稔, 藤田有可里, 米田祥, 細川吉弥, 木村武量, 小澤純二, 岩橋博見, 下村伊一郎

糖尿病, 62(Suppl.1) S-317, Apr, 2019
高インスリン血症と反応性低血糖を呈し,全エクソーム解析を行った1例

堀谷恵美, 藤田真吾, 宮下洋平, 黒田陽平, 藤田有可里, 細川吉弥, 木村武量, 徳永あゆみ, 福井健司, 小澤純二, 朝野仁裕, 鎌田佳宏, 嶺尾郁夫, 岩橋博見, 岩橋博見, 下村伊一郎

糖尿病(Web), 62(Suppl), 2019
糖尿病発症前の既往最高BMI群別にみた2型糖尿病患者の罹病期間と内因性インスリン分泌能との関連

小澤栄稔, 福井健司, 元田沙織, 石橋千咲, 藤田真吾, 細川吉弥, 藤田有可里, 馬殿恵, 米田祥, 木村武量, 徳永あゆみ, 小澤純二, 岩橋博見, 下村伊一郎

糖尿病, 61(Suppl.1) S-152, Apr, 2018
インスリンデグルデク1日1回および2回注射による日内グルコース値変動をFreeStyleリブレにて観察した1型糖尿病の1例

細川吉弥, 田矢直大, 米田祥, 小澤純二, 木村武量, 宮下和幸, 西澤均, 前田法一, 大月道夫, 松岡孝昭, 岩橋博見, 下村伊一郎

糖尿病, 61(Suppl.1) S-175, Apr, 2018

Research Projects

Analysis of the mechanisms of beta cell destruction in fulminant type 1 diabetes with special reference to CD300e and viral infection related factors

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Imagawa Akihisa
Resolution of Ch25h mechanism at pancreatic beta cells in fulminant type 1 diabetes

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2020

Hosokawa Yoshiya
Analysis of the mechanisms of beta cell destruction by DNA and RNA viruses identified in the pancreases of patients with fulminant type 1 diabetes

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Imagawa Akihisa, YONEDA Sho, HOSOKAWA Yoshiya, BADEN Megu
Etiology of fulminant type 1 diabetes mellitus

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

IMAGAWA AKIHISA, HANAFUSA Toshiaki, FUKUI Kenji, NAKATA Shinsuke, YOSHIKAWA Atsushi, HOSOKAWA Yoshiya, BADEN Megu

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