論文

査読有り
2019年4月15日

The role of glycogen in development and adult fitness in Drosophila

Development
  • Takayuki Yamada
  • ,
  • Okiko Habara
  • ,
  • Yuka Yoshii
  • ,
  • Ryota Matsushita
  • ,
  • Hitomi Kubo
  • ,
  • Yosui Nojima
  • ,
  • Takashi Nishimura

146
8
開始ページ
dev176149
終了ページ
dev176149
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1242/dev.176149
出版者・発行元
The Company of Biologists

The polysaccharide glycogen is an evolutionarily conserved storage form of glucose. However, the physiological significance of glycogen metabolism on homeostatic control throughout the animal life cycle remains incomplete. Here, we describe Drosophila mutants that have defective glycogen metabolism. Null mutants of glycogen synthase (GlyS) and glycogen phosphorylase (GlyP) displayed growth defects and larval lethality, indicating that glycogen plays a crucial role in larval development. Unexpectedly, however, a certain population of larvae developed into adults with normal morphology. Semi-lethality in glycogen mutants during the larval period can be attributed to the presence of circulating sugar trehalose. Homozygous glycogen mutants produced offspring, indicating that glycogen stored in oocytes is dispensable for embryogenesis. GlyS and GlyP mutants showed distinct metabolic defects in the levels of circulating sugars and triglycerides in a life stage-specific manner. In adults, glycogen as an energy reserve is not crucial for physical fitness and lifespan under nourished conditions, but glycogen becomes important under energy stress conditions. This study provides a fundamental understanding of the stage-specific requirements for glycogen metabolism in the fruit fly.

リンク情報
DOI
https://doi.org/10.1242/dev.176149
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30918052
URL
https://syndication.highwire.org/content/doi/10.1242/dev.176149

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