We describe an approach to calibrate Single Event Effect (SEE)-based detectors in monoenergetic fields and apply the resulting semi-empiric responses to more generalmixed-field cases in which a broad variety of particle species and energy spectra are present. The calibration of the response functions is based both on experimental proton (30-200MeV) and neutron (5-300MeV) data and considerations derived from Monte Carlo simulations using the FLUKA Monte Carlo code. The application environments include the quasi-monoenergetic neutrons at RCNP, the atmospheric-like VESUVIO spallation spectrum and the CHARM high-energy accelerator test facility. The agreement between the mixed-field response and that predicted through the mono-energetic calibration is within +/- 30% for the broad variety of cases considered and thus regarded as highly successful for mixed-field monitoring applications.