2018年8月12日
ATP as a pathophysiologic mediator of bacteria-host crosstalk in the gastrointestinal tract.
International Journal of Molecular Sciences
- ,
- ,
- 巻
- 19
- 号
- 8
- 開始ページ
- Pii:E2371
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3390/ijms19082371
Extracellular nucleotides, such as adenosine triphosphate (ATP), are released from host cells including nerve termini, immune cells, injured or dead cells, and the commensal bacteria that reside in the gut lumen. Extracellular ATP interacts with the host through purinergic receptors, and promotes intercellular and bacteria-host communication to maintain the tissue homeostasis. However, the release of massive concentrations of ATP into extracellular compartments initiates acute and chronic inflammatory responses through the activation of immunocompetent cells (e.g., T cells, macrophages, and mast cells). In this review, we focus on the functions of ATP as a pathophysiologic mediator that is required for the induction and resolution of inflammation and inter-species communication.
- リンク情報
- ID情報
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- DOI : 10.3390/ijms19082371
- PubMed ID : 30103545
- PubMed Central 記事ID : PMC6121306