論文

査読有り 筆頭著者 責任著者 国際誌
2021年2月16日

Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation.

Nature Communications
  • Yosuke Kurashima
  • Takaaki Kigoshi
  • Sayuri Murasaki
  • Fujimi Arai
  • Kaoru Shimada
  • Natsumi Seki
  • Yun-Gi Kim
  • Koji Hase
  • Hiroshi Ohno
  • Kazuya Kawano
  • Hiroshi Ashida
  • Toshihiko Suzuki
  • Masako Morimoto
  • Yukari Saito
  • Ai Sasou
  • Yuki Goda
  • Yoshikazu Yuki
  • Yutaka Inagaki
  • Hideki Iijima
  • Wataru Suda
  • Masahira Hattori
  • Hiroshi Kiyono
  • 全て表示

12
1
開始ページ
1067
終了ページ
1067
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41467-021-21277-2

Increases in adhesive and invasive commensal bacteria, such as Escherichia coli, and subsequent disruption of the epithelial barrier is implicated in the pathogenesis of inflammatory bowel disease (IBD). However, the protective systems against such barrier disruption are not fully understood. Here, we show that secretion of luminal glycoprotein 2 (GP2) from pancreatic acinar cells is induced in a TNF-dependent manner in mice with chemically induced colitis. Fecal GP2 concentration is also increased in Crohn's diease patients. Furthermore, pancreas-specific GP2-deficient colitis mice have more severe intestinal inflammation and a larger mucosal E. coli population than do intact mice, indicating that digestive-tract GP2 binds commensal E. coli, preventing epithelial attachment and penetration. Thus, the pancreas-intestinal barrier axis and pancreatic GP2 are important as a first line of defense against adhesive and invasive commensal bacteria during intestinal inflammation.

リンク情報
DOI
https://doi.org/10.1038/s41467-021-21277-2
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33594081
ID情報
  • DOI : 10.1038/s41467-021-21277-2
  • PubMed ID : 33594081

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