論文

査読有り 筆頭著者
2009年2月

Histone H2B Deubiquitination Is Required for Transcriptional Activation of FLOWERING LOCUS C and for Proper Control of Flowering in Arabidopsis

PLANT PHYSIOLOGY
  • *Robert Jeffrey Schmitz
  • ,
  • *Yosuke Tamada
  • ,
  • Mark Robert Doyle
  • ,
  • Xiaoyu Zhang
  • ,
  • Richard Mark Amasino

149
2
開始ページ
1196
終了ページ
1204
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1104/pp.108.131508
出版者・発行元
AMER SOC PLANT BIOLOGISTS

The spectrum of histone modifications at a given locus is a critical determinant for the correct output of gene expression. In Arabidopsis (Arabidopsis thaliana), many studies have examined the relationship between histone methylation and gene expression, but few studies exist on the relationship between other covalent histone modifications and gene expression. In this work, we describe the role of histone H2B deubiquitination in the activation of gene expression and the consequence of a perturbation of histone H2B deubiquitination in the timing of the floral transition in Arabidopsis. A mutation in a H2B deubiquitinase, UBIQUITIN-SPECIFIC PROTEASE26 (UBP26), results in an early-flowering phenotype. In the ubp26 mutant, mRNA levels of the floral repressor FLOWERING LOCUS C (FLC) and other related family members is decreased. Furthermore, this mutant accumulates H2B monoubiquitination, and has decreased levels of H3K36 trimethylation and increased levels of H3K27 trimethylation at the FLC locus. Thus, UBP26 is required for transcriptional activation of FLC through H2B deubiquitination and is consistent with a model in which deubiquitination is necessary for the accumulation of H3K36 trimethylation and the proper level of transcriptional activation.

リンク情報
DOI
https://doi.org/10.1104/pp.108.131508
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19091875
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000263129400050&DestApp=WOS_CPL
URL
http://europepmc.org/abstract/med/19091875
URL
http://orcid.org/0000-0002-4845-4867
ID情報
  • DOI : 10.1104/pp.108.131508
  • ISSN : 0032-0889
  • ORCIDのPut Code : 46770528
  • PubMed ID : 19091875
  • Web of Science ID : WOS:000263129400050

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