論文

国際誌
2014年7月10日

Circulation-independent differentiation pathway from extraembryonic mesoderm toward hematopoietic stem cells via hemogenic angioblasts.

Cell reports
  • Yosuke Tanaka
  • ,
  • Veronica Sanchez
  • ,
  • Nozomu Takata
  • ,
  • Tomomasa Yokomizo
  • ,
  • Yojiro Yamanaka
  • ,
  • Hiroshi Kataoka
  • ,
  • Philipp S Hoppe
  • ,
  • Timm Schroeder
  • ,
  • Shin-Ichi Nishikawa

8
1
開始ページ
31
終了ページ
9
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.celrep.2014.05.055

A large gap exists in our understanding of the course of differentiation from mesoderm to definitive hematopoietic stem cells (HSCs). Previously, we reported that Runx1(+) cells in embryonic day 7.5 (E7.5) embryos contribute to the hemogenic endothelium in the E10.5 aorta-gonad-mesonephros (AGM) region and HSCs in the adult bone marrow. Here, we show that two Runx1(+) populations subdivided by Gata1 expression exist in E7.5 embryos. The hemogenic endothelium and the HSCs are derived only from the Runx1(+)Gata1(-) population. A subset of this population moves from the extra- to intraembryonic region during E7.5-E8.0, where it contributes to the hemogenic endothelium of the dorsal aorta (DA). Migration occurs before the heartbeat is initiated, and it is independent of circulation. This suggests a developmental trajectory from Runx1(+) cells in the E7.5 extraembryonic region to definitive HSCs via the hemogenic endothelium.

リンク情報
DOI
https://doi.org/10.1016/j.celrep.2014.05.055
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24981862
ID情報
  • DOI : 10.1016/j.celrep.2014.05.055
  • PubMed ID : 24981862

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