Wakabayashi Yoshihiro

Profile Information

Affiliation: Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization

Degree: 農学(Mar, 2002, 東京大学)

J-GLOBAL ID: 200901028569978424
researchmap Member ID: 6000010052

Research Interests

Research Areas

Research History

Apr, 2021 - Present

National Agriculture and Food Research Organization
Apr, 2020 - Mar, 2021

National Agriculture and Food Research Organization
Apr, 2018 - Mar, 2020

Ministry of Agriculture, Forestry and Fisheries
Apr, 2016 - Mar, 2018

主任研究員, 畜産研究部門・繁殖性向上ユニット, 農業・食品技術総合研究機構
Apr, 2013 - Mar, 2016

主任研究員, 動物科学研究領域・動物生産生理機能研究ユニット, 農業生物資源研究所
Apr, 2008 - Mar, 2013

任期付研究員, 動物科学研究領域・動物生産生理機能研究ユニット, 農業生物資源研究所
Oct, 2006 - Mar, 2008

Research fellow, Health Sciences Center, University of Colorado
Apr, 2006 - Sep, 2006

学術研究支援員, 農学生命科学研究科, 東京大学大学院
Apr, 2003 - Mar, 2006

日本学術振興会・特別研究員
Apr, 2002 - Mar, 2003

非常勤研究員, 発生形態研究室, （財）東京都神経科学総合研究所

Education

Apr, 1999 - Mar, 2002

Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Papers

Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats

Takashi YAMAMURA, Hiroaki OKAMURA, Yoshihiro WAKABAYASHI

Journal of Reproduction and Development, 69(4) 218-222, 2023 Peer-reviewedCorresponding author
Silkworm Recombinant Bovine Zona Pellucida Protein 4 as a Potential Female Immunocontraceptive Antigen; Impaired Sperm-Oocyte Interaction and Ovarian Dysfunction.

Tatematsu KI, Ikeda M, Wakabayashi Y, Yamamura T, Kikuchi K, Noguchi J, Sezutsu H

Journal of Reproduction and Development, 67(6) 402-406, Dec, 2021 Peer-reviewed
Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats

Yoshihiro WAKABAYASHI, Hiroaki OKAMURA, Takashi YAMAMURA

Journal of Reproduction and Development, 67(6) 352-358, Dec, 2021 Peer-reviewedLead authorCorresponding author
Neurokinin 3 Receptor-Selective Agonist, Senktide, Decreases Core Temperature in Japanese Black Cattle

S. Nakamura, M. Miwa, Y. Morita, S. Ohkura, T. Yamamura, Y. Wakabayashi, S. Matsuyama

Domestic Animal Endocrinology, 74 106522-106522, Jul, 2020 Peer-reviewed
Peripheral administration of κ-opioid receptor antagonist stimulates gonadotropin-releasing hormone pulse generator activity in ovariectomized, estrogen-treated female goats

T. Sasaki, D. Ito, T. Sonoda, Y. Morita, Y. Wakabayashi, T. Yamamura, H. Okamura, S. Oishi, T. Noguchi, N. Fujii …

Domestic Animal Endocrinology, 68 83-91, Jul, 2019 Peer-reviewed
A Single Pheromone Receptor Gene Conserved across 400 My of Vertebrate Evolution.

Hikoyu Suzuki, Hidefumi Nishida, Hiro Kondo, Ryota Yoda, Tetsuo Iwata, Kanako Nakayama, Takayuki Enomoto, Jiaqi Wu, Keiko Moriya-Ito, Masao Miyazaki …

Molecular biology and evolution, 35(12) 2928-2939, Dec 1, 2018 Peer-reviewed
Structure and zonal expression of olfactory receptors in the olfactory epithelium of the goat, Capra hircus.

Josh Elisha R Octura, Kei-Ichiro Maeda, Yoshihiro Wakabayashi

The Journal of veterinary medical science, 80(6) 913-920, Jun 29, 2018 Peer-reviewedCorresponding author
Mapping of KNDy neurons and immunohistochemical analysis of the interaction between KNDy and substance P neural systems in goat

Hiroaki Okamura, Takashi Yamamura, Yoshihiro Wakabayashi

Journal of Reproduction and Development, 63(6) 571-580, Dec, 2017 Peer-reviewedCorresponding author
A neurokinin 3 receptor-selective agonist accelerates pulsatile luteinizing hormone secretion in lactating cattle

Sho Nakamura, Yoshihiro Wakabayashi, Takashi Yamamura, Satoshi Ohkura, Shuichi Matsuyama

BIOLOGY OF REPRODUCTION, 97(1) 81-90, Jul, 2017 Peer-reviewed
An administration of TAK-683 at a minimally effective dose for luteinizing hormone stimulation under the absence of the ovary induces luteinizing hormone surge in ovary-intact goats

Nahoko Kanai, Natsumi Endo, Satoshi Ohkura, Yoshihiro Wakabayashi, Hisanori Matsui, Hirokazu Matsumoto, Kaori Ishikawa, Akira Tanaka, Tatsuya Watanabe, Hiroaki Okamura …

Journal of Reproduction and Development, 63(3) 305-310, Jun, 2017 Peer-reviewed
Differential changes in luteinizing hormone secretion after administration of the investigational metastin/kisspeptin analog TAK-683 in goats

Natsumi Endo, Chie Tamesaki, Satoshi Ohkura, Yoshihiro Wakabayashi, Hisanori Matsui, Akira Tanaka, Tatsuya Watanabe, Hiroaki Okamura, Tomomi Tanaka

ANIMAL REPRODUCTION SCIENCE, 159 87-93, Aug, 2015 Peer-reviewed
Effects of intravenous administration of neurokinin receptor subtype-selective agonists on gonadotropin-releasing hormone pulse generator activity and lutemizing hormone secretion in goats

Takashi Yamamura, Yoshihiro Wakabayashi, Satoshi Ohkura, Victor M. Navarro, Hiroaki Okamura

Journal of Reproduction and Development, 61(1) 20-29, Feb, 2015 Peer-reviewed
The Luteinising Hormone Surge-Generating System is Functional in Male Goats as in Females: Involvement of Kisspeptin Neurones in the Medial Preoptic Area

F. Matsuda, K. Nakatsukasa, Y. Suetomi, Y. Naniwa, D. Ito, N. Inoue, Y. Wakabayashi, H. Okamura, K. -I. Maeda, Y. Uenoyama …

JOURNAL OF NEUROENDOCRINOLOGY, 27(1) 57-65, Jan, 2015 Peer-reviewed
Ovarian and Hormonal Responses to Follicular Phase Administration of Investigational Metastin/Kisspeptin Analog, TAK-683, in Goats

Y. Goto, N. Endo, K. Nagai, S. Ohkura, Y. Wakabayashi, A. Tanaka, H. Matsui, M. Kusaka, H. Okamura, T. Tanaka

REPRODUCTION IN DOMESTIC ANIMALS, 49(2) 338-342, Apr, 2014 Peer-reviewed
Identification of an Olfactory Signal Molecule that Activates the Central Regulator of Reproduction in Goats

Ken Murata, Shigeyuki Tamogami, Masamichi Itou, Yasutaka Ohkubo, Yoshihiro Wakabayashi, Hidenori Watanabe, Hiroaki Okamura, Yukari Takeuchi, Yuji Mori

CURRENT BIOLOGY, 24(6) 681-686, Mar, 2014 Peer-reviewed
The Effects of Chronic Subcutaneous Administration of an Investigational Kisspeptin Analog, TAK-683, on Gonadotropin-Releasing Hormone Pulse Generator Activity in Goats

Takashi Yamamura, Yoshihiro Wakabayashi, Kohei Sakamoto, Hisanori Matsui, Masami Kusaka, Tomomi Tanaka, Satoshi Ohkura, Hiroaki Okamura

NEUROENDOCRINOLOGY, 100(2-3) 250-264, 2014 Peer-reviewed
Differential Effects of Continuous Exposure to the Investigational Metastin/Kisspeptin Analog TAK-683 on Pulsatile and Surge Mode Secretion of Luteinizing Hormone in Ovariectomized Goats

Tomomi Tanaka, Satoshi Ohkura, Yoshihiro Wakabayashi, Takenobu Kuroiwa, Kiyosuke Nagai, Natsumi Endo, Akira Tanaka, Hisanori Matsui, Masami Kusaka, Hiroaki Okamura

JOURNAL OF REPRODUCTION AND DEVELOPMENT, 59(6) 563-568, Dec, 2013 Peer-reviewed
A Population of Kisspeptin/Neurokinin B Neurons in the Arcuate Nucleus May Be the Central Target of the Male Effect Phenomenon in Goats

Kohei Sakamoto, Yoshihiro Wakabayashi, Takashi Yamamura, Tomomi Tanaka, Yukari Takeuchi, Yuji Mori, Hiroaki Okamura

PLOS ONE, 8(11) e81017, Nov, 2013 Peer-reviewed
Potential Role of Transient Receptor Potential Channel M5 in Sensing Putative Pheromones in Mouse Olfactory Sensory Neurons

Arisa Oshimoto, Yoshihiro Wakabayashi, Anna Garske, Roberto Lopez, Shane Rolen, Michael Flowers, Nicole Arevalo, Diego Restrepo

PLOS ONE, 8(4) e61990, Apr, 2013 Peer-reviewed
Electrophysiological and Morphological Evidence for Synchronized GnRH Pulse Generator Activity Among Kisspeptin/Neurokinin B/Dynorphin A (KNDy) Neurons in Goats

Yoshihiro Wakabayashi, Takashi Yamamura, Kohei Sakamoto, Yuji Mori, Hiroaki Okamura

JOURNAL OF REPRODUCTION AND DEVELOPMENT, 59(1) 40-48, Feb, 2013 Peer-reviewedLead author

Misc.

シバヤギ弓状核キスペプチンニューロン群の神経活動変化とパルス状LH分泌変化の相関

Journal of Reproduction and Development, j71-j71, Sep, 2022 Lead author
ニューロキニンB受容体作動薬投与が夏季のウシ体温に及ぼす影響

中村翔, 三輪雅史, 森田康広, 山村崇, 若林嘉浩, 大蔵聡, 松山秀一

Journal of Reproduction and Development, 65(Suppl) 97-j97, Sep, 2019
ニューロキニン作動薬の持続投与が家畜の繁殖機能に及ぼす影響

山村崇, 松山秀一, 中村翔, 若林嘉浩

日本畜産学会大会講演要旨, 125th 147, Mar 28, 2019
ニューロキニンB受容体作動薬投与がウシの体温に及ぼす影響

中村翔, 三輪雅史, 山村崇, 若林嘉浩, 松山秀一

第111回日本繁殖生物学会大会講演要旨掲載号, 64(Suppl) 92, Sep, 2018
κ‐オピオイド受容体拮抗剤の末梢投与はシバヤギのパルス状LH分泌を亢進する

佐々木拓弥, 伊藤太祐, 園田朋也, 若林嘉浩, 山村崇, 岡村裕昭, 大石真也, 藤井信孝, 森田康広, 上野山賀久 …

日本畜産学会大会講演要旨, 124th 211-211, Mar 28, 2018
The effect of continuous intravenous administration of NK3R agonist on gonadotrophin release in cattle

YAMAMURA Takashi, MATSUYAMA Shuichi, NAKAMURA Sho, ENDO Natsumi, TANAKA Tomomi, WAKABAYASHI Yoshihiro

The Journal of Reproduction and Development Supplement, 111 P-4-P-4, 2018
ニューロキニン作動薬を用いた家畜の新規卵胞発育制御法の開発研究

山村崇, 松山秀一, 中村翔, 大蔵聡, 若林嘉浩

日本畜産学会大会講演要旨, 122nd 161, Mar 28, 2017
泌乳期ウシにおけるニューロキニンB受容体作動薬が黄体形成ホルモンのパルス状分泌に及ぼす影響

中村翔, 若林嘉浩, 山村崇, 大蔵聡, 松山秀一

日本下垂体研究会学術集会プログラム・講演要旨集, 32nd 66, 2017
ニューロキニンB受容体作動薬投与が泌乳期ウシの分娩後初回排卵へ及ぼす影響

中村翔, 若林嘉浩, 山村崇, 大蔵聡, 松山秀一

東日本家畜受精卵移植技術研究会大会資料, 33rd 29, 2017
長時間作用型PEG化NK3受容体作動薬の創製

桑井真司, 大石真也, 三須良介, 大野浩章, 山村崇, 若林嘉浩, 岡村裕昭, 藤井信孝

日本薬学会年会要旨集(CD-ROM), 136th ROMBUNNO.29T‐PM07, 2016
PEG修飾による長時間作用型NK3受容体作動薬の創製

桑井真司, 大石真也, 三須良介, 岡崎志穂, 山本昂輝, 大野浩章, 山村崇, 若林嘉浩, 岡村裕昭, 藤井信孝

メディシナルケミストリーシンポジウム講演要旨集, 33rd 92, Nov 1, 2015
弓状核へのNeurokinin B局所投与により誘起された神経活動上昇は反対側の弓状核キスペプチンニューロン群へ伝達される

若林嘉浩, 山村崇, 大蔵聡, 岡村裕昭

J Reprod Dev, 61(Suppl Japanese Issue) J122, Sep 5, 2015
ニューロキニン作動薬を用いた新たな卵胞発育制御技術の開発研究

山村崇, 若林嘉浩, 三須良介, 大石真也, 大蔵聡, 藤井信孝, 岡村裕昭

日本畜産学会大会講演要旨, 119th 197, Mar 28, 2015
タキキニンファミリーの神経ペプチドがGnRHパルスジェネレータにおよぼす影響

山村崇, 若林嘉浩, 大蔵聡, 岡村裕昭

J Reprod Dev, 60(Suppl Japanese Issue) J114, Aug 10, 2014
シバヤギ弓状核キスペプチンニューロン分布領域へのNeurokinin B局所投与がGnRHパルス産生におよぼす影響

若林嘉浩, 山村崇, 大蔵聡, 岡村裕昭

J Reprod Dev, 60(Suppl Japanese Issue) J114, Aug 10, 2014
新規κオピオイド受容体拮抗剤の末梢投与がシバヤギGnRHパルスジェネレーター活動におよぼす効果

伊藤太祐, 中務桂佑, 若林嘉浩, 山村崇, 岡村裕昭, 大石真也, 野口太朗, 藤井信孝, 上野山賀久, 束村博子 …

J Reprod Dev, 59(Suppl Japanese Issue) J103-j103, Aug 20, 2013
ヤギの卵胞期におけるキスペプチン誘導体TAK-683の投与が卵巣活動,性腺刺激ホルモンおよび卵巣ステロイドホルモン分泌におよぼす影響

後藤侑, 遠藤なつ美, 永井清亮, 大蔵聡, 若林嘉浩, 田中晃, 松井久典, 日下雅美, 岡村裕昭, 田中知己

Journal of Reproduction and Development, 59(Suppl Japanese Issue), 2013
弓状核キスペプチンーニューロンの神経活動同期に関わるNeurokinin B/Neurokinin3receptorシグナリングの役割

若林嘉浩, 山村崇, 岡村裕昭

GPCR研究会プログラム・抄録集, 10th 21, 2013
Kisspeptin and GnRH Pulse Generation

Hiroaki Okamura, Hiroko Tsukamura, Satoshi Ohkura, Yoshihisa Uenoyama, Yoshihiro Wakabayashi, Kei-ichiro Maeda

KISSPEPTIN SIGNALING IN REPRODUCTIVE BIOLOGY, 784 297-323, 2013 Peer-reviewed
NKBは弓状核キスペプチン/NKBニューロンに作用してGnRHパルスを産生させる

若林嘉浩, 山村崇, 大蔵聡, 本間玲実, 坂本光平, 森裕司, 岡村裕昭

J Reprod Dev, 58(Suppl Japanese Issue) J146, Aug 20, 2012

Professional Memberships

Research Projects

a

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2027
反芻動物が発情特異的に発散するフェロモン・匂い分子の探索と作用解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

若林嘉浩
Investigation for pathway of pheromone that regulates reproductive function in ruminants

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Sep, 2020 - Mar, 2022
繁殖促進効果をもつ反芻動物のフェロモン作用機構の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2016 - Mar, 2018

若林嘉浩
Effect of Neurokinin B on the activity of the GnRH pulse generator

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Wakabayashi Yoshihiro
Control of physiological function and behavior by mammalian pheromone

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2009 - Mar, 2014

MORI Yuji, TAKEUCHI Yukari, WATANEBE Hidenori, OKAMURA Hiroaki, YAMAGISHI Kimiko, TAKAHASHI Shin-ichirou, ICHIKAWA Masumi, KABA Hideto, TANIGUCHI Mutsuo, WAKABAYASHI Yoshihiro, KIYOKAWA Yasushi
Research for a mechanism for generation of GnRH pulse regulated by neural activity of kisspeptin neurons in the arcuate nucleus

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

WAKABAYASHI Yoshihiro
The neural circuit of "male effect" pheromone signaling pathway in goat brain

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (Start-up), Grant-in-Aid for Young Scientists (Start-up), Japan Society for the Promotion of Science, 2008 - 2009

WAKABAYASHI Yoshihiro
鋤鼻神経細胞株を用いた検定系による哺乳類フェロモン分子の探索

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2003 - 2005

若林嘉浩

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