論文

国際誌
2022年8月26日

Site-specific differences in T lymphocyte composition of the gastric mucosa after Helicobacter pylori eradication.

Medicine
  • Masaya Iwamuro
  • Takahide Takahashi
  • Natsuki Watanabe
  • Makoto Abe
  • Hiroyuki Sakae
  • Yoshiyasu Kono
  • Hiromitsu Kanzaki
  • Takehiro Tanaka
  • Seiji Kawano
  • Fumio Otsuka
  • Yoshiro Kawahara
  • Hiroyuki Yanai
  • Hiroyuki Okada
  • 全て表示

101
34
開始ページ
e30241
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/MD.0000000000030241

In our earlier work, we revealed that inflammation of the lesser curvature of the gastric body and antrum could constitute independent risk factors for gastric cancer development, while inflammation of the greater curvature was not. The aims of this study were as follows: first, to reveal the differences between T lymphocyte populations of the gastric antrum and the greater and lesser curvatures of the gastric body in patients after Helicobacter pylori eradication; second, to analyze the correlation between the composition of the stomach-resident T lymphocytes and time from H. pylori eradication; and third, to evaluate the sex differences in T lymphocyte subsets after H. pylori eradication. To investigate site-specific differences in stomach-resident T lymphocytes after H. pylori eradication, we performed flow cytometry analysis on samples taken from the gastric antrum, greater curvature of the gastric body, and lesser curvature of the gastric body of 20 patients. We also analyzed the correlation between the composition of the stomach-resident T lymphocytes and the time from H. pylori eradication. The lymphocyte subsets of the antrum and lesser curvature of the body were similar. In contrast, compared to those in the greater curvature of the gastric body, CD4+/CD3+ lymphocyte subsets (43.8 ± 19.4% vs 31.7 ± 14.6%) were elevated in the lesser curvature of the body, whereas CD8+/CD3+ (67.1 ± 21.3% vs 80.4 ± 12.0%), CD7+/CD3+ (91.2 ± 4.6% vs 93.7 ± 3.8%), CCR4+/CD3+ (7.7 ± 8.1% vs 10.4 ± 7.0%), CD45RA+/CD3+CD4+ (27.2 ± 24.8% vs 39.5 ± 20.8%), and CD45RA+/CD3+CD4- (14.2 ± 11.1% vs 18.7 ± 11.5) were lower. Linear regression analysis showed a negative correlation between the time after H. pylori eradication and CD4+/CD3+ (P < .05, R2 = 0.198). There were no significant differences between men and women with respect to the lymphocyte populations. These results indicate that there are site-specific differences in lymphocyte composition in the stomach after H. pylori eradication.

リンク情報
DOI
https://doi.org/10.1097/MD.0000000000030241
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/36042652
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410669
ID情報
  • DOI : 10.1097/MD.0000000000030241
  • PubMed ID : 36042652
  • PubMed Central 記事ID : PMC9410669

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