2014年9月
Synthesis and inhibitory activity on hepatitis C virus RNA replication of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)aniline analogs
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 24
- 号
- 17
- 開始ページ
- 4276
- 終了ページ
- 4280
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bmcl.2014.07.019
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Using our recently developed assay system for full-genome-length hepatitis C virus (HCV) RNA replication in human hepatoma-derived Li23 cells (ORL8), we identified 4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)aniline analog la as a novel HCV inhibitor. Structural modifications of la provided a series of sulfonamides 7 with much more potent HCV RNA replication-inhibitory activity than ribavirin. Compound 7a showed an additive anti-HCV effect in combination with standard anti-HCV therapy (IFN-alpha plus ribavirin). Since 7a generated reactive oxygen species (ROS) in the ORL8 system and its anti-HCV activity was blocked by vitamin E, its anti-HCV activity may be mediated at least in part by ROS. (C) 2014 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.bmcl.2014.07.019
- ISSN : 0960-894X
- eISSN : 1464-3405
- Web of Science ID : WOS:000341339300040