Yusuke Sasano

Profile Information

Affiliation: 講師, 大学院薬学研究科, 東北大学

Degree: 博士（薬学）(東北大学)

J-GLOBAL ID: 201901010724313885
researchmap Member ID: B000373727

Research Interests

Research Areas

Research History

Jan, 2020 - Present

Lecturer, Graduate School of Pharmaceutical Sciences, Tohoku University
Oct, 2014 - Dec, 2019

Assistant Professor, Graduate School of Pharmaceutical Sciences, Tohoku University
Nov, 2014 - Nov, 2015

Research Associate, Department of Chemistry (Prof. Ryan A. Shenvi), The Scripps Research Institute
Apr, 2012 - Sep, 2014

Research Instructor, Graduate School of Pharmaceutical Sciences, Tohoku University
Apr, 2010 - Mar, 2012

Research Fellowship for Young Scientists (DC1), JSPS

Education

Apr, 2010 - Mar, 2012

(Prof. Yoshiharu Iwabuchi), Graduate School of Pharmaceutical Sciences, Tohoku University
Apr, 2008 - Mar, 2010

(Prof. Yoshiharu Iwabuchi), Graduate School of Pharmaceutical Sciences, Tohoku University
Apr, 2004 - Mar, 2008

(Prof. Yoshiharu Iwabuchi), Faculty of Pharmaceutical Sciences, Tohoku University

Committee Memberships

May, 2018 - Present

世話人, 次世代を担う有機化学シンポジウム

Papers

Comprehensive Structural and Electronic Properties of 2-Azaadamantane N-Oxyl Derivatives Correlated with Their Catalytic Ability

Masaki Nishijima, Yusuke Sasano, Yoshiharu Iwabuchi, Yasuyuki Araki

ACS Omega, 8 49067-49072, Dec 26, 2023 Peer-reviewed
Determination of antibiotics by amperometry using nortropine N-oxyl, a highly active nitroxyl radical

Tetsuya Ono, Fumiya Sato, Masayuki Kumano, Sachiko Komatsu, Kyoko Sugiyama, Kazuhiro Watanabe, Kentaro Yoshida, Yusuke Sasano, Tsutomu Fujimura, Yoshiharu Iwabuchi …

Analytical Sciences, Jun 28, 2023
Asymmetric Total Synthesis of Cytotrienin A: Late-stage Installation of C11 Side Chain onto the Macrolactam Scaffold.

Yuki Tateishi, Ryo Sato, Shingo Komatsu, Masatsugu Noguchi, Shota Nagasawa, Yusuke Sasano, Naoki Kanoh, Yoshiharu Iwabuchi

Angewandte Chemie (International ed. in English), e202303140, May 22, 2023
Identification of the Optimal Framework for Nitroxyl Radical/Hydroxylamine in Copper-Cocatalyzed Aerobic Alcohol Oxidation

Masaki Toda, Yusuke Sasano, Masaya Takahashi, Shogo Fujiki, Koki Kasabata, Tetsuya Ono, Katsuhiko Sato, Yoshitomo Kashiwagi, Yoshiharu Iwabuchi

The Journal of Organic Chemistry, 88(3) 1434-1444, Feb 3, 2023 Peer-reviewed
Azetidine synthesis by La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines.

Yuse Kuriyama, Yusuke Sasano, Yoshiharu Iwabuchi

Frontiers in chemistry, 11 1251299-1251299, 2023
Sequential click modification of a lithium-ion endohedral fullerene connecting small molecules through a dieneazide linker

Shogo Fujiki, Takumi Takada, Shota Nagasawa, Hiroshi Okada, Yusuke Sasano, Eunsang Kwon, Yutaka Matsuo, Yoshiharu Iwabuchi

CHEMICAL COMMUNICATIONS, 59(9) 1237-1240, Jan, 2023
Electrochemical reactions of highly active nitroxyl radicals with thiol compounds

Masayuki Kumano, Kyoko Sugiyama, Fumiya Sato, Sachiko Komatsu, Kazuhiro Watanabe, Tetsuya Ono, Kentaro Yoshida, Yusuke Sasano, Yoshiharu Iwabuchi, Tsutomu Fujimura …

Analytical Sciences, Dec 28, 2022
Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy for the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis

Naoki Kanoh, Yuta Terajima, Suguru Tanaka, Ryusei Terashima, Hiromichi Nishiyama, Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi, Shinichi Nishimura, Hideaki Kakeya

The Journal of Organic Chemistry, 86(23) 16231-16248, Dec 3, 2021 Peer-reviewed
Design, Synthesis, and Antifungal Activity of 16,17-Dihydroheronamide C and ent-Heronamide C

Naoki Kanoh, Ryusei Terashima, Hiromichi Nishiyama, Yuta Terajima, Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi, Hiroaki Saito, Syusuke Egoshi, Kosuke Dodo …

The Journal of Organic Chemistry, 86(23) 16249-16258, Dec 3, 2021
A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins

Ryosuke Segawa, Hiroyuki Takeda, Takeshi Yokoyama, Momoha Ishida, Chihiro Miyata, Taiji Saito, Ryosuke Ishihara, Tomoya Nakagita, Yusuke Sasano, Naoki Kanoh …

Biochemical Pharmacology, 194 114819-114819, Dec, 2021 Peer-reviewed
Nitroxyl Radical/Copper-Catalyzed Electrooxidation of Alcohols and Amines at Low Potentials

Kyoko Sugiyama, Yusuke Sasano, Sachiko Komatsu, Kentaro Yoshida, Tetsuya Ono, Tsutomu Fujimura, Yoshiharu Iwabuchi, Yoshitomo Kashiwagi, Katsuhiko Sato

Chemical and Pharmaceutical Bulletin, 69(10) 1005-1009, Oct 1, 2021
Chromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols

Shota Nagasawa, Shogo Fujiki, Yusuke Sasano, Yoshiharu Iwabuchi

JOURNAL OF ORGANIC CHEMISTRY, 86(9) 6952-6968, May, 2021
Expansion of Substrate Scope for Nitroxyl Radical/Copper-Catalyzed Aerobic Oxidation of Primary Alcohols: A Guideline for Catalyst Selection

Yusuke Sasano, Aoto Yamaichi, Ryota Sasaki, Shota Nagasawa, Yoshiharu Iwabuchi

CHEMICAL & PHARMACEUTICAL BULLETIN, 69(5) 488-497, May, 2021
Catalysis of electro-oxidation of antibiotics by nitroxyl radicals and the electrochemical sensing of vancomycin

Tetsuya Ono, Kyoko Sugiyama, Sachiko Komatsu, Masayuki Kumano, Kentaro Yoshida, Takenori Dairaku, Tsutomu Fujimura, Yusuke Sasano, Yoshiharu Iwabuchi, Yoshitomo Kashiwagi …

RSC Advances, 11(35) 21622-21628, 2021
Highly Regioselective 5-endo-tet Cyclization of 3,4-Epoxy Amines into 3-Hydroxypyrrolidines Catalyzed by La(OTf)3.

Yuse Kuriyama, Yusuke Sasano, Yoshihiko Hoshino, Shun-Ichiro Uesugi, Aoto Yamaichi, Yoshiharu Iwabuchi

Chemistry (Weinheim an der Bergstrasse, Germany), 27(6) 1961-1965, Nov 15, 2020
Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A

Sachiko Komatsu, Yusuke Sasano, Kyoko Sugiyama, Kazuhiro Watanabe, Masayuki Kumano, Kentaro Yoshida, Tetsuya Ono, Yoshiharu Iwabuchi, Tsutomu Fujimura, Katsuhiko Sato …

Oct 5, 2020
Electrochemical determination of choline using nortropine-N-oxyl for a non-enzymatic system

Yoshitomo Kashiwagi, Tetsuya Ono, Fumiya Sato, Masayuki Kumano, Kentaro Yoshida, Takenori Dairaku, Yusuke Sasano, Yoshiharu Iwabuchi, Katsuhiko Sato

Sensing and Bio-Sensing Research, 27 100302-100302, Feb, 2020 Peer-reviewed
Safe and Scalable Aerobic Oxidation by 2-Azaadamantan-2-ol (AZADOL)/NO <inf>x</inf> Catalysis: Large-Scale Preparation of Shi's Catalyst

Yusuke Sasano, Hikaru Sato, Shinsuke Tadokoro, Masami Kozawa, Yoshiharu Iwabuchi

Organic Process Research and Development, 23(4) 571-577, Apr 19, 2019
Electrochemical Detection of Triglycerides Based on an Enzymatic Reaction and Electrocatalytic Oxidation with Nortropine‐N‐oxyl

Tetsuya Ono, Katsuhiko Sato, Yusuke Sasano, Kentaro Yoshida, Takenori Dairaku, Yoshiharu Iwabuchi, Yoshitomo Kashiwagi

Electroanalysis, 31(4) 603-606, Apr, 2019
Ln(OTf) <inf>3</inf> -catalysed highly regioselective alcoholysis of 2,3-epoxy alcohols

Daichi Nakamura, Yusuke Sasano, Yoshiharu Iwabuchi

Organic and Biomolecular Chemistry, 17(14) 3581-3589, Jan 1, 2019

Misc.

Photosensitized Singlet Oxygen-supported Alcohol Oxidation Mediated by Nitroxyl Radical Catalyst

西嶋政樹, 長澤翔太, 笹野裕介, 荒木保幸, 岩渕好治, 和田健彦

日本化学会春季年会講演予稿集(Web), 103rd, 2023
THE UTILITY OF OXOAMMONIUM SPECIES IN ORGANIC SYNTHESIS: BEYOND ALCOHOL OXIDATION

Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi

Heterocycles, 105(1) 61-114, 2022
Studies directed toward the creation of induced pluripotent small (iPS) molecules based on naturally occurring polyene macrolactams

叶直樹, 叶直樹, 寺嶋優太, 田中卓, 寺島隆世, 西山大陸, 長澤翔太, 笹野裕介, 岩渕好治

複素環化学討論会講演要旨集, 50th, 2021
アンサマクロラクタム抗腫瘍活性天然物Cytotrienin Aの合成研究

建石悠貴, 佐藤亮, 小松慎吾, 野口正嗣, 長澤翔太, 笹野裕介, 叶直樹, 岩渕好治

創薬懇話会講演要旨集, 2021, 2021
Synthetic study of the marine alkaloid chartelline C benzene analog

永山晶子, 黒田麻由, 上杉惇一郎, 笹野裕介, 叶直樹, 岩渕好治

日本薬学会年会要旨集(Web), 141st, 2021
Synthetic Study of Cytotrienin A (2)

建石悠貴, 佐藤亮, 小松慎吾, 野口正嗣, 長澤翔太, 笹野裕介, 叶直樹, 岩渕好治

日本薬学会年会要旨集(Web), 141st, 2021
Aerobic oxidation of primary alcohols with nitroxyl radical/copper catalysis and one-pot reaction consisting of the alcohol oxidation and Z-selective HWE Reaction

山一蒼仁, 笹野裕介, 田中卓, 叶直樹, 岩渕好治

日本薬学会年会要旨集(CD-ROM), 140th (Web), 2020
Synthetic Study on Himalensines

小山純平, 笹野裕介, 叶直樹, 岩渕好治

万有仙台シンポジウム, 31st, 2020
海洋性アルカロイドchartelline Cベンゼンアナログの合成研究

永山晶子, 黒田麻由, 上杉惇一郎, 笹野裕介, 叶直樹, 岩渕好治

日本薬学会東北支部大会講演要旨集, 59th, 2020
Synthetic Study of Cytotrienin A

建石悠貴, 佐藤亮, 小松慎吾, 長澤翔太, 笹野裕介, 叶直樹, 岩渕好治

日本薬学会年会要旨集(CD-ROM), 140th (Web), 2020
ニトロキシルラジカル/銅触媒的な化学選択的アルコール空気酸化-HWE反応によるα,β-不飽和エステルの擬ワンポット合成

笹野裕介, 山一蒼仁, 田中卓, 叶直樹, 岩渕好治

有機合成シンポジウム講演要旨集, 115th, 2019
高度縮合多環式ユズリハアルカロイド・カリシフィリンAの合成研究

小山純平, 井口かおり, 笹野裕介, 叶直樹, 岩渕好治

創薬懇話会講演要旨集, 2019, 2019
ニトロキシルラジカル/銅触媒を用いたアルコール空気酸化-HWE反応によるα,β-不飽和エステルの擬ワンポット合成

山一蒼仁, 笹野裕介, 田中卓, 叶直樹, 岩渕好治

日本薬学会年会要旨集(CD-ROM), 139th, 2019
Cytotrienin Aの合成研究:鈴木カップリングによるトリエン単位構築の検討

建石悠貴, 佐藤亮, 小松慎吾, 野口正嗣, 長澤翔太, 笹野裕介, 叶直樹, 岩渕好治

日本薬学会東北支部大会講演要旨集, 58th, 2019
Synthetic Studies on (+)-Cytotrienin A, an Apoptosis Inducing Ansamycin Antibiotic

岩渕好治, 佐藤亮, 笹野裕介, 小松慎吾, 野口正嗣, 掛谷秀昭, 長田裕之, 叶直樹

天然有機化合物討論会講演要旨集(Web), 60th, 2018
抗腫瘍活性ユズリハアルカロイドDaphnicyclidin AのBCD環部の立体選択的合成

岡本健寛, 笹野裕介, 川住宗生, 宮城琢, 叶直樹, 岩渕好治

日本薬学会年会要旨集(CD-ROM), 138th, 2018
ニトロキシルラジカル/銅触媒を用いたアルコール空気酸化-HWE反応によるα,β-不飽和エステルの擬ワンポット合成

山一蒼仁, 笹野裕介, 田中卓, 叶直樹, 岩渕好治

日本薬学会東北支部大会講演要旨集, 57th, 2018
高度縮合多環式ユズリハアルカロイドカリシフィリンAの合成研究

小山純平, 井口かおり, 笹野裕介, 叶直樹, 岩渕好治

反応と合成の進歩シンポジウム講演要旨集, 44th, 2018
ランタニドトリフラートを触媒としたエポキシアルコールの位置選択的開環反応の最適化

中村大地, 笹野裕介, 上杉惇一郎, 叶直樹, 岩渕好治

日本薬学会年会要旨集(CD-ROM), 137th, 2017
抗腫瘍活性ユズリハアルカロイドDaphniyunnine Dの合成研究

小山純平, 井口かおり, 笹野裕介, 叶直樹, 岩渕好治

日本薬学会年会要旨集(CD-ROM), 137th, 2017

Professional Memberships

Research Projects

Development of Chemoselective Catalytic Oxidation Accelerated by the Use of Electroanalysis and Capillary Electrophoresis-Mass Spectrometry

Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (A), Japan Society for the Promotion of Science, Sep, 2021 - Mar, 2026
Digitalization-driven Transformative Organic Synthesis (Digi-TOS)

Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (A), Japan Society for the Promotion of Science, Sep, 2021 - Mar, 2026
有機ニトロキシルラジカルー遷移金属協奏触媒の機能創成を機軸とする精密有機分子構築

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

岩渕好治, 笹野裕介, 山越博幸, 長澤翔太
新規多座配位ニトロキシル／銅触媒を用いる高難度不斉アルコール空気酸化反応への挑戦

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

笹野裕介
Precise construction of organic molecules based on organonitroxyl radical-transition metal hybrid catalysts

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Iwabuchi Yoshiharu
Aerobic Asymmetric Alcohol Oxidation Using Chiral Tridentate Nitroxyl Radical/Copper Catalysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2020

Sasano Yusuke
Development of nitrogen-containing versatile chiral building blocks driven by novel chemoselctive catalysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Iwabuchi Yoshiharu
Enantioselective Aerobic Alcohol Oxidation Using Chiral Ligand-Hybridized Nitroxyl Radical/Copper Catalysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Sasano Yusuke
Chemoselective aerobic oxidation of amino alcohols using nitroxyl radical-copper catalysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

SASANO Yusuke
電子伝達系構築を機軸とするニトロキシルラジカル触媒を用いた新規空気酸化反応の開発

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, 2010 - 2011

笹野裕介

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