2009年10月30日
Fibulin-5 contributes to microfibril assembly in human periodontal ligament cells
Acta Histochemica et Cytochemica
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- 巻
- 42
- 号
- 5
- 開始ページ
- 151
- 終了ページ
- 157
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1267/ahc.09021
The elastic system fibers comprise oxytalan, elaunin and elastic fibers, which differ in their relative microfibril and elastin content. Human periodontal ligaments (PDL) contain only oxytalan fibers (pure microfibrils) among them. Since fibulin-5 regulates the organization of elastic fibers to link the fibers to cells, we hypothesized that fibulin-5 may contribute to the formation of oxytalan fibers. We used siRNA for fibulin-5 in PDL cell culture to examine the extracellular deposition of fibrillin-1 and -2, which are the major components of microfibrils. Fibulin-5 was labeled on microfibrils positive for fibrillin-1 and -2. Fibulin-5 suppression reduced the level of fibrillin-1 and -2 deposition to 60% of the control level. These results suggest that fibulin-5 may control the formation of oxytalan fibers, and play a role in the homeostasis of oxytalan fibers. © 2009 The Japan Society of Histochemistry and Cytochemistry.
- リンク情報
- ID情報
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- DOI : 10.1267/ahc.09021
- ISSN : 0044-5991
- ISSN : 1347-5800
- PubMed ID : 19918324
- PubMed Central 記事ID : PMC2775106
- SCOPUS ID : 70350580335