2010 - 2012
CLEC2-PLAG complex-induced oncogenic transformation in the intra-lymphatic microenvironment
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
- Grant number
- 22390345
- Japan Grant Number (JGN)
- JP22390345
- Grant amount
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- (Total)
- 19,890,000 Japanese Yen
- (Direct funding)
- 15,300,000 Japanese Yen
- (Indirect funding)
- 4,590,000 Japanese Yen
We developed novel antibodies specific for human and mouse podoplanin (PMab-1,NZ-1.2) sold in MBL, Imgenex, Sigma, and Millipore. Immunohistochemical studies on the oral squamous cell carcinoma (SCC) revealed that platelets exist between SCC and lymphatic endothelial cells at the luminal side of lymphatic vessels where SCC attached. The platelets may contribute to the lymphogenous metastasis of SCC. The adhesion activity to human lymphatic endothelial cells was higher in podoplanin-positive SCC than in podoplanin-negative SCC, and the adhesion of SCC was blocked by NZ-1.2. Anti-podoplanin may be useful for the inhibition of the lymphogenous metastasis of SCC.
- Link information
- ID information
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- Grant number : 22390345
- Japan Grant Number (JGN) : JP22390345