Yoshinori Seko

Profile Information

J-GLOBAL ID: 202101020305689399
researchmap Member ID: R000030138

Research Areas

Life sciences / Cardiology / oxidative stress

Papers

Oxidative stress-responsive apoptosis-inducing protein in patients with heterozygous familial hypercholesterolemia.

Kayoko Sato, Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Nobuhisa Hagiwara, Yoshinori Seko

Heart and vessels, 36(12) 1923-1932, Jul 26, 2021
Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in cerebral ischemia/reperfusion injury.

Masao Kishimoto, Jun Suenaga, Hajime Takase, Kota Araki, Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Ryu Ueno, Nobuyuki Shimizu …

Scientific reports, 9(1) 13512-13512, Sep 18, 2019
Elevation of the vitreous body concentrations of oxidative stress-responsive apoptosis-inducing protein (ORAIP) in proliferative diabetic retinopathy.

Yuta Suzuki, Takako Yao, Ko Okumura, Yoshinori Seko, Shigehiko Kitano

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 257(7) 1519-1525, Jul, 2019
Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in High Glucose-Induced Apoptosis in Rat Cardiac Myocytes and Murine Pancreatic β-Cells.

Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Yoshinori Seko

Cells, 6(4), Oct 18, 2017
The Changing Landscape for Stroke Prevention in AF Findings From the GLORIA-AF Registry Phase 2

Menno V. Huisman, Kenneth J. Rothman, Miney Paquette, Christine Teutsch, Hans-Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Chang Sheng Ma, Kristina Zint, Amelie Elsaesser …

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 69(7) 777-785, Feb, 2017
Plasma levels of oxidative stress-responsive apoptosis inducing protein (ORAIP) in patients with atrial fibrillation.

Takako Yao, Kentaro Tanaka, Tsutomu Fujimura, Kimie Murayama, Shuichi Fukuda, Ko Okumura, Yoshinori Seko

International journal of cardiology, 222 528-530, Nov 1, 2016
Marked Elevation of Plasma Levels of Oxidative Stress-Responsive Apoptosis-Inducing Protein in Dialysis Patients.

Kentaro Tanaka, Takako Yao, Tsutomu Fujimura, Kimie Murayama, Shuichi Fukuda, Ko Okumura, Yoshinori Seko

Kidney international reports, 1(4) 321-324, Nov, 2016
Plasma levels of oxidative stress-responsive apoptosis inducing protein (ORAIP) in rats subjected to physicochemical oxidative stresses.

Takako Yao, Tsutomu Fujimura, Kimie Murayama, Yoshinori Seko

Bioscience reports, 36(2), 2016
Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis.

Yoshinori Seko, Tsutomu Fujimura, Takako Yao, Hikari Taka, Reiko Mineki, Ko Okumura, Kimie Murayama

Scientific reports, 5 13737-13737, Sep 8, 2015
A Case of Takayasu's Arteritis with Total Occlusion of the Abdominal Aorta Treated Only with Oral Medication for More Than 40 Years.

Kenichi Aizawa, Jun Fujii, Yoshinori Seko

Annals of vascular diseases, 8(2) 124-7, 2015
Basal cardiomyopathy develops in rabbits with ventricular tachyarrhythmias induced by a single injection of adrenaline.

Terunao Ashida, Tetsuya Takato, Gen Matsuzaki, Yoshinori Seko, Jun Fujii, Sachio Kawai

International heart journal, 55(1) 78-83, 2014
[An elderly woman with macrocytic anemia and acute high-output heart failure following acute bleeding due to a gastric ulcer].

Gen Matsuzaki, Terunao Ashida, Masao Akanuma, Jun Fujii, Yoshinori Seko

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 50(3) 409-12, 2013
Atrio-His (James) accessory pathway and infiltration of γδ T cells in the heart with MELAS.

Gen Matsuzaki, Akifumi Kushiyama, Kenta Uto, Morio Shoda, Yoshinori Seko

BMJ case reports, 2011, Feb 2, 2011
Ventricular tachyarrhythmia-related basal cardiomyopathy in rabbits with vagal stimulation--a novel experimental model for inverted Takotsubo-like cardiomyopathy.

Tetsuya Takato, Terunao Ashida, Yoshinori Seko, Jun Fujii, Sachio Kawai

Journal of cardiology, 56(1) 85-90, Jul, 2010
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.

Hideo Negishi, Tomoko Osawa, Kentaro Ogami, Xinshou Ouyang, Shinya Sakaguchi, Ryuji Koshiba, Hideyuki Yanai, Yoshinori Seko, Hiroshi Shitara, Keith Bishop …

Proceedings of the National Academy of Sciences of the United States of America, 105(51) 20446-51, Dec 23, 2008
Gamma-delta T-cell-mediated dilated cardiomyopathy.

Norifumi Takeda, Yoshinori Seko, Noboru Oriuchi, Ryozo Nagai

International journal of cardiology, 125(1) 130-2, Mar 28, 2008
Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3.

Yoshinori Seko, Hideo Yagita, Ko Okumura, Miyuki Azuma, Ryozo Nagai

Cardiovascular research, 75(1) 158-67, Jul 1, 2007
A case of neonatal lupus erythematosus presenting delayed dilated cardiomyopathy with circulating autoantibody to annexin A6.

Yoshinori Seko, Akihiro Matsumoto, Taira Fukuda, Yasushi Imai, Tsutomu Fujimura, Hikari Taka, Reiko Mineki, Kimie Murayama, Yasunobu Hirata, Ryozo Nagai

International heart journal, 48(3) 407-15, May, 2007
Giant cell and Takayasu arteritis.

Yoshinori Seko

Current opinion in rheumatology, 19(1) 39-43, Jan, 2007
Effect of the angiotensin II receptor blocker olmesartan on the development of murine acute myocarditis caused by coxsackievirus B3.

Yoshinori Seko

Clinical science (London, England : 1979), 110(3) 379-86, Mar, 2006

Misc.

198

Oxidative Stress-responsive Apoptosis Inducing Protein(ORAIP)は癌性悪液質誘発性心臓損傷を媒介する(Oxidative Stress-Responsive Apoptosis Inducing Protein(ORAIP) Mediates Cancer Cachexia-Induced Cardiac Injury)

世古義規, 野中美希, 呉林なごみ, 上園保仁, 立石健祐, 八尾貴子

日本循環器学会学術集会抄録集, 82回 OJ02-6, Mar, 2018
肺高血圧症患者において酸化ストレス応答アポトーシス誘導蛋白質(ORAIP)の血漿中濃度は肺血行動態と関連している(Plasma Levels of Oxidative Stress-Responsive Apoptosis Inducing Protein(ORAIP) is Associated with Pulmonary Hemodynamics in Patients with Pulmonary Hypertension)

山方勇樹, 池田聡司, 中田智夫, 米倉剛, 江口正倫, 古賀聖士, 室屋隆浩, 小出優史, 河野浩章, 八尾貴子 …

日本循環器学会学術集会抄録集, 82回 PJ052-2, Mar, 2018
肺高血圧症における酸化ストレス応答性アポトーシス誘導タンパク(ORAIP)の意義

山方勇樹, 池田聡司, 米倉剛, 古賀聖士, 室屋隆浩, 小出優史, 河野浩章, 八尾貴子, 世古義規, 前村浩二

血管, 41(1) 35-35, Jan, 2018
糖尿病網膜症の硝子体中の酸化ストレス応答性アポトーシス誘導因子ORAIP濃度の解析

鈴木裕太, 八尾貴子, 世古義規, 北野滋彦

糖尿病合併症, 31(Suppl.1) 341-341, Oct, 2017
心房細動患者における血漿中oxidative stress-responsive apoptosis inducing protein(ORAIP)濃度の著しい上昇(Marked Elevation of Plasma Levels of Oxidative Stress-Responsive Apoptosis Inducing Protein(ORAIP) in Patients with Atrial Fibrillation)

世古義規, 八尾貴子

日本循環器学会学術集会抄録集, 81回 PJ-335, Mar, 2017
Oxidative stress-responsive apoptosis inducing protein(ORAIP)は虚血/再灌流(低酸素/再酸素化)を媒介する Jak/STATおよびMEK/ERKシグナル経路を介する心筋細胞のアポトーシスの誘導(Oxidative Stress-Responsive Apoptosis Inducing Protein(ORAIP) Mediates Ischemia/Reperfusion(Hypoxia/Reoxygenation)-Induced Apoptosis of Cardiac Myocytes via Jak/STAT and MEK/ERK Signaling)

世古義規, 八尾貴子

日本循環器学会学術集会抄録集, 81回 PJ-727, Mar, 2017
末期腎不全例での新規生理活性因子・酸化ストレス応答性アポトーシス誘導蛋白(ORAIP)の著明な血漿中濃度上昇

田中健太郎, 八尾貴子, 世古義規

日本腎臓学会誌, 58(3) 378-378, May, 2016
胃潰瘍の出血により急性高心拍出量性心不全を呈した高齢者大球性貧血の1例

松崎弦, 芦田映直, 赤沼真夫, 藤井潤, 世古義規

日本老年医学会雑誌, 50(3) 409-412, May, 2013
胃潰瘍の出血により急性心不全を呈した高齢者の1例

松崎弦, 芦田映直, 世古義規

日本老年医学会雑誌, 49(5) 650-650, Sep, 2012
逆たこつぼ型心筋症家兎モデルにおける病変の局在とその機序について

河合祥雄, 鈴木宏昌, 末吉徳芳, 芦田映直, 高遠哲也, 世古義規, 藤井潤, 長浜眞人

日本心臓病学会誌, 7(Suppl.I) 338-338, Aug, 2012
41年間内科治療のみで経過観察し得た腹部大動脈閉塞を伴った高安動脈炎の1例

松崎弦, 世古義規, 藤井潤

日本内科学会関東地方会, 586回 25-25, Mar, 2012
アドレナリン投与により心室不整脈が出現した家兎にみられる逆たこつぼ型心筋症様心基部全周病変

高遠哲也, 芦田映直, 松崎弦, 世古義規, 藤井潤, 河合祥雄

日本心臓病学会誌, 6(Suppl.I) 262-262, Aug, 2011
7年間服薬していた降圧薬を休薬し16年後も寛解状態を維持している高血圧の一例

松崎弦, 芦田映直, 世古義規, 藤井潤

日本高血圧学会総会プログラム・抄録集, 33回 366-366, Oct, 2010
頸部迷走神経刺激家兎にみられる心室性不整脈発生と心基部、僧帽弁、乳頭筋病変の形成求心性迷走神経の役割

高遠哲也, 芦田映直, 松崎弦, 世古義規, 藤井潤, 河合祥雄

日本心臓病学会誌, 5(Suppl.I) 252-252, Aug, 2010
スピロノラクトンによる疼痛を伴った女性化乳房がエプレレノンに変更後改善した原発性アルドステロン症の1例

高遠哲也, 芦田映直, 松崎弦, 世古義規

診断と治療, 98(5) 859-861, May, 2010
母親が肥大型心筋症を呈し,娘がLGL症候群を合併したMELASの親子例

松崎弦, 世古義規, 梶沼宏, 櫛山暁史

日本循環器学会関東甲信越地方会(Web), 216th, 2010
高血圧患者における家庭血圧測定および降圧薬服用アドヒアランス各診療科間の比較

高遠哲也, 世古義規, 大西由希子, 北里博仁, 吉田洋子, 佃克則, 菊池方利, 赤沼真夫, 芦田映直

日本高血圧学会総会プログラム・抄録集, 32回 203-203, Oct, 2009
家兎頸部迷走神経刺激後に出現する左心室基部心筋病変逆たこつぼ型心筋症の新しい実験モデル

高遠哲也, 芦田映直, 世古義規, 藤井潤, 河合祥雄

日本心臓病学会誌, 4(Suppl.I) 292-292, Aug, 2009
頸動脈内膜中膜複合体厚(IMT)とPWV,ABI,AIとの関連についての検討

高遠哲也, 八尾貴子, 世古義規, 芦田映直

血圧, 15(10) 900-901, Oct, 2008
高血圧患者における降圧薬服用コンプライアンスの検討専門病院と一般クリニックの比較

高遠哲也, 芦田映直, 山田奈美恵, 杉山卓郎, 世古義規, 別宮啓之

日本高血圧学会総会プログラム・抄録集, 31回 206-206, Oct, 2008

Research Projects

川崎病冠動脈炎における酸化ストレス誘導蛋白（ORAIP)の役割と新規治療薬の開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

菅沼栄介, 世古義規
胸腹部大動脈術後脊髄再灌流障害の新たな細胞障害機序の解明と治療法の開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

中井秀和, 藤田靖之, 山中勝弘, 世古義規, 川本篤彦, 岡田健次
Elucidation of the relationship of novel apoptosis-inducing substances to the pathophysiology of pulmonary arterial hypertension

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

EGUCHI Masamichi
Identification of the Receptor for ORAIP That Mediates Cardiac Response to Oxidative Stresses and Development of Treatment

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2003 - 2004

SEKO Yoshinori, SHINDO Takayuki
Identification of the ligands for Cardiac Orphan G protein -Coupled Receptors and Development of T herapy Modulating Cardiac Function

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2002

SEKO Yoshinori, SAKURAI Takeshi
心血管系の負荷応答と病態形成:遺伝子転写シグナルと病態生理に基づく治療戦略の確立

科学研究費助成事業, 基盤研究(A), 日本学術振興会, 2000 - 2002

永井良三, 世古義規, 高橋利之, 杉浦清了, 小室一成
Development of inhibitors for the activation of cardiovascular interstitial ceils

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 1999 - 2001

NAGAI Ryozo, KURIHARA Hiroki, SEKO Yoshinori
Development of the Specific Immunotherapy for Myocarditis, Dilated Cardiomyopathy(Chronic Myocarditis), and Takayasu Arteritis.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1999 - 2000

SEKO Yoshinori, MISAKI Yoshikata, YAMAMOTO Kazuhiko
Purification and Identification of the Bioactive Subs tance That Mediates Cardiac Response to the Ischemia Reperfusion Stresses and Development of Treatment

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1999 - 2000

SEKO Yoshinori, KANGAWA Kenji, TOBE Kazuyuki
拡張型心筋症(慢性心筋炎)のモデル動物の作成と治療法開発への応用

科学研究費助成事業, 萌芽的研究, 日本学術振興会, 1999 - 1999

世古義規, 三崎義堅, 山本一彦
Elucidation of the Molecular Mechanism of Cardiac Response to the Ischemia Reperfusion Stresses and Establishment of Treatment Based on the Molecular Mechanism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1997 - 1998

SEKO Yoshinori, TOBE Kazuyuki
Molecular Mechanisms of Genetic Response of Myocardial Cells to Cytotoxic Stress

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1997 - 1998

KURABAYASHI Masahiko, ARAI Masashi
血管平滑筋細胞における転写因子Idの機能と発現調節機序

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1997 - 1997

倉林正彦, 世古義規
Development of Molecular Biologic Diagnostic and Therapeutic Method of Asymptomatic Myocardial Ischemia and Unstable Angina

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 1995 - 1997

SEKO Yoshinori, ENOKAWA Yoshifumi, TOBE Kazuyuki
心筋虚血再灌流障害における細胞内情報伝達機構の解明および抗接着分子療法の確立

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 1996 - 1996

世古義規, 高橋直之, 戸辺一之
心筋虚血再灌流障害に対する抗接着分子療法の確立および心筋細胞応答の分子機構の解析

科学研究費助成事業, 一般研究(C), 日本学術振興会, 1995 - 1995

世古義規, 江野川義文, 戸辺一之
The elucidation of the roles of cell-adhesion molecules in heart diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Developmental Scientific Research (B), Japan Society for the Promotion of Science, 1993 - 1995

YAZAKI Yoshio, KATOH Hirohisa, YAMAZAKI Tsutomu, SEKO Yoshinori
心筋虚血再灌流障害の細胞内・細胞間分子機構の解明とそれに基づいた予防法の確立

科学研究費助成事業, 一般研究(C), 日本学術振興会, 1994 - 1994

世古義則, 戸辺一之, 永井良三
心筋虚血再潅流障害の分子機構の解明および接着分子タンパクを用いた予防法の確立

科学研究費助成事業, 一般研究(C), 日本学術振興会, 1993 - 1993

世古義規, 戸辺一之, 山崎力, 永井良三
Intracellular Signaling of Stretch Mediated Myocyte Growth

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (B), Japan Society for the Promotion of Science, 1991 - 1992

YAZAKI Yoshio, YAMAZAKI Tsutomu, KOMURO Issei, NAGAI Ryozo

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