2022年4月7日
Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC).
Chemical communications (Cambridge, England)
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- 巻
- 58
- 号
- 29
- 開始ページ
- 4635
- 終了ページ
- 4638
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1039/d2cc00272h
We developed a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8). The PROTAC induced degradation of HDAC8 without affecting the levels of other HDACs in cellular assays, and inhibited the growth of T-cell leukemia Jurkat cells more potently than a conventional HDAC8 inhibitor.
- ID情報
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- DOI : 10.1039/d2cc00272h
- PubMed ID : 35311871