論文

査読有り
2012年

Sub-acute Demyelinating Polyradiculoneuropathy as an Initial Symptom of Peripheral T Cell Lymphoma, Not Otherwise Specified (PTCL-NOS)

INTERNAL MEDICINE
  • Kazunobu Kawanishi
  • ,
  • Yasuyo Ohyama
  • ,
  • Yoshitake Kanai
  • ,
  • Tikara Hirase
  • ,
  • Hirokazu Tanaka
  • ,
  • Junichi Miyatake
  • ,
  • Youichi Tatsumi
  • ,
  • Takashi Ashida
  • ,
  • Hirokazu Nakamine
  • ,
  • Itaru Matsumura

51
15
開始ページ
2015
終了ページ
2020
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2169/internalmedicine.51.7457
出版者・発行元
JAPAN SOC INTERNAL MEDICINE

Here we report the first case of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), who initially presented with peripheral neuropathy. Nerve conduction, cerebral spinal fluid studies and his clinical course were compatible with sub-acute demyelinating polyradiculoneuropathy. In addition, left cervical lymph node swelling was observed on admission. Diagnosis of PTCL-NOS was made by the histological, immuno-histochemical, and Southern blot analyses on the biopsy specimen from the enlarged lymph node. Combination chemotherapy composed of cyclophosphamide, vincristine, doxorubicin and prednisolone (CHOP) was effective for polyneuropathy as well as for lymphoma. Several antibodies relating to paraneoplastic syndrome such as Ma1, Ma2, Amphiphysin, CV2, Ri, Yo and Hu were all negative. Because sural nerve biopsy performed prior to CHOP therapy revealed no infiltration of lymphoma cells, immune dysfunction mediated by some cytokine or unidentified autoantibody related to PTCL-NOS was thought to be involved in the polyradiculoneuropathy.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.51.7457
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22864129
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000308319600011&DestApp=WOS_CPL

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