2013年4月
Enhanced generation of reactive oxygen species by interferon-gamma may have contributed to successful treatment of invasive pulmonary aspergillosis in a patient with chronic granulomatous disease
INTERNATIONAL JOURNAL OF HEMATOLOGY
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- 巻
- 97
- 号
- 4
- 開始ページ
- 505
- 終了ページ
- 510
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s12185-013-1315-y
- 出版者・発行元
- SPRINGER JAPAN KK
Invasive pulmonary aspergillosis (IPA) is a life-threatening complication of chronic granulomatous disease (CGD), a rare inherited disorder of phagocytes that is characterized by a defect in the production of reactive oxygen species (ROS) caused by mutations in NADPH oxidase 2. Here, we report a case of successful treatment of IPA complicated with CGD by the administration of interferon-gamma (IFN-gamma) in combination with voriconazole. The patient carried a splice site mutation in the CYBB gene, and the neutrophils could produce a certain amount of ROS. In this case, augmentation of ROS generation in the patient's neutrophils was observed after in vivo IFN-gamma treatment, which may be attributable to the induction of a normal CYBB gene in the myeloid progenitor cells. This treatment, in combination with voriconazole, may have contributed to the reversal of IPA in this patient. These results suggest that the in vivo use of IFN-gamma may augment ROS generation in CGD neutrophils, thus leading to the successful treatment of severe IPA.
- リンク情報
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- DOI
- https://doi.org/10.1007/s12185-013-1315-y
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000317475500011&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-84891712855&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-9662-5093
- ID情報
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- DOI : 10.1007/s12185-013-1315-y
- ISSN : 0925-5710
- ORCIDのPut Code : 38624278
- SCOPUS ID : 84891712855
- Web of Science ID : WOS:000317475500011