論文

国際誌
2021年3月

Possible nosocomial transmission of virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.

Annals of hematology
  • Yoshiyuki Onda
  • Junya Kanda
  • Nozomu Hanaoka
  • Mizuki Watanabe
  • Yasuyuki Arai
  • Masakatsu Hishizawa
  • Tadakazu Kondo
  • Kouhei Yamashita
  • Miki Nagao
  • Tsuguto Fujimoto
  • Akifumi Takaori-Kondo
  • 全て表示

100
3
開始ページ
753
終了ページ
761
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00277-021-04414-1

Adenovirus (ADV)- or BK virus (BKV)-associated hemorrhagic cystitis (HC) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Several risk factors have been previously reported; however, it is unclear whether virus-associated HC can be transmitted. To clarify this point, we performed a retrospective cohort study on 207 consecutive patients who underwent allo-HSCT at Kyoto University Hospital between 2012 and 2018. We evaluated the incidence and risk factors of virus-associated HC and performed a phylogenetic analysis of the ADV partial sequence. The median age at transplantation was 50 (range, 17-68) years. Fifty-eight patients (28%) developed HC. ADVs were detected in 18 cases, BKVs were detected in 51, both were detected in 12, and only John Cunningham virus (JCV) was detected in 1 case. No factor was significantly associated with HC. However, both ADV- and BKV-HC occurred intensively between April 2016 and September 2017, which suggested possible nosocomial transmission of ADV and BKV. Genome sequencing of the hexon, E3, and penton regions of detected ADVs identified 7 cases of ADV type 11, 2 cases of type 35, and 3 cases of a type 79-related strain. A sequence analysis revealed that these strains in each type were almost identical, except for one case of a type 79-related strain. In conclusion, ADV-HCs with possible nosocomial transmission were described based on genotyping of the virus and partial sequencing of the viral genome. Although viral HC after allo-HSCT is thought to mainly be due to reactivation of a latent virus, nosocomial transmission of ADV or BKV should also be considered.

リンク情報
DOI
https://doi.org/10.1007/s00277-021-04414-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33439306
ID情報
  • DOI : 10.1007/s00277-021-04414-1
  • PubMed ID : 33439306

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