Yutaka Takahashi

Profile Information

Affiliation: Associate Professor, Graduate School of Medicine, Osaka University

Degree: 博士（保健学）(大阪大学大学院)

Researcher number: 40353461
J-GLOBAL ID: 201801019685987024
researchmap Member ID: B000311913

Research Interests

Research Areas

Life sciences / Tumor biology / 腫瘍免疫学

Research History

Apr, 2012 - Mar, 2015

Postdoctral associate, Masonic Cancer Center, University of Minnesota
Apr, 2002 - Mar, 2008

研究員, 癌研究所物理部, （財）癌研究会

Awards

Apr, 2004

大阪対ガン協会ガン研究助成奨励金（基礎の部 ), 大阪対ガン協会

高橋豊
Apr, 2003

大阪対ガン協会ガン研究助成奨励金（基礎の部 ), 大阪対ガン協会

高橋豊

Papers

104

Radiation therapy enhances systemic antitumor efficacy in PD-L1 therapy regardless of sequence of radiation in murine osteosarcoma

Shohei Katsuki, Yutaka Takahashi, Keisuke Tamari, Kazumasa Minami, Wataru Takenaka, Yoriko Ibuki, Junya Yamamoto, Shotaro Tatekawa, Kazuhiko Hayashi, Yuji Seo …

PLOS ONE, 17(7) e0271205-e0271205, Jul 11, 2022 Peer-reviewedCorresponding author
Enhancement of antitumor immune response by radiation therapy combined with dual immune checkpoint inhibitor in a metastatic model of HER2-positive murine tumor

Sayaka Misaki, Satoshi Murata, Miyuki Shimoji, Takayasu Iwai, Andreas Michael Sihombing, Ken Aoki, Yutaka Takahashi, Yoshiyuki Watanabe

Japanese Journal of Radiology, 40(12) 1307-1315, Jun 28, 2022 Peer-reviewed
High Dose Local Photon Irradiation Is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance the Abscopal Response in a Murine Pancreatic Carcinoma Model.

Junya Yamamoto, Yutaka Takahashi, Kazumasa Minami, Keisuke Tamari, Shohei Katsuki, Wataru Takenaka, Shotaro Tatekawa, Kazuhiko Hayashi, Yuji Seo, Fumiaki Isohashi …

Cancers, 14(9), Apr 22, 2022 Peer-reviewedCorresponding author
A Consistent Protocol Reveals a Large Heterogeneity in the Biological Effectiveness of Proton and Carbon-Ion Beams for Various Sarcoma and Normal-Tissue-Derived Cell Lines.

Masashi Yagi, Yutaka Takahashi, Kazumasa Minami, Taeko Matsuura, Jin-Min Nam, Yasuhito Onodera, Takashi Akagi, Takuya Maeda, Tomoaki Okimoto, Hiroki Shirato …

Cancers, 14(8), Apr 15, 2022 Peer-reviewedLead author
Poly (ADP-ribose) polymerase inhibitors sensitize cancer cells to hypofractionated radiotherapy through altered selection of DNA double-strand break repair pathways

Yuji Seo, Keisuke Tamari, Yutaka Takahashi, Kazumasa Minami, Shotaro Tatekawa, Fumiaki Isohashi, Osamu Suzuki, Yuichi Akino, Kazuhiko Ogawa

International Journal of Radiation Biology, 1-27, Dec 17, 2021
Chk1 suppression leads to a reduction in the enhanced radiation-induced invasive capability on breast cancer cells.

Takanori Adachi, Wantong Zhao, Kazumasa Minami, Yuhki Yokoyama, Daisuke Okuzaki, Rika Kondo, Yutaka Takahashi, Keisuke Tamari, Yuji Seo, Fumiaki Isohashi …

Journal of radiation research, 62(5) 764-772, Sep 13, 2021
抗CTLA-4抗体を使った免疫療法と放射線療法の併用治療は、膵管癌の局所のみならず遠隔巣においても抗腫瘍効果が得られる

山本純也, 高橋豊, 皆巳和賢, 玉利慶介, 勝木翔平, 武中渉, 松谷英樹, 立川章太郎, 小川和彦, 小泉雅彦

日本癌学会総会記事, 80回 [J12-5], Sep, 2021
マウス骨肉腫モデルに対する抗PD-L1抗体治療において治療順番に関わらず放射線治療は全身性の抗腫瘍効果を引き起こす

勝木翔平, 高橋豊, 玉利慶介, 皆巳和賢, 武中渉, 山本純也, 松谷英樹, 立川章太郎, 小川和彦, 小泉雅彦

日本癌学会総会記事, 80回 [J19-2], Sep, 2021
抗CTLA-4抗体併用下での放射線治療の線量増加による全身性抗腫瘍効果の増強について

武中渉, 高橋豊, 皆巳和賢, 玉利慶介, 立川章太郎, 勝木翔平, 山本純也, 松谷英樹, 小泉雅彦, 小川和彦

日本癌学会総会記事, 80回 [P12-1], Sep, 2021
p16-HNSCC患者の血漿中cell-free DNAを用いたdigital-PCRによるHPV-DNA検出

松谷英樹, 玉利慶介, 立川章太郎, 皆巳和賢, 高橋豊, 武中渉, 勝木翔平, 山本純也, 小川和彦, 小泉雅彦

日本癌学会総会記事, 80回 [P14-7], Sep, 2021
抗CTLA-4抗体を使った免疫療法と放射線療法の併用治療は、膵管癌の局所のみならず遠隔巣においても抗腫瘍効果が得られる

山本純也, 高橋豊, 皆巳和賢, 玉利慶介, 勝木翔平, 武中渉, 松谷英樹, 立川章太郎, 小川和彦, 小泉雅彦

日本癌学会総会記事, 80回 [J12-5], Sep, 2021
マウス骨肉腫モデルに対する抗PD-L1抗体治療において治療順番に関わらず放射線治療は全身性の抗腫瘍効果を引き起こす

勝木翔平, 高橋豊, 玉利慶介, 皆巳和賢, 武中渉, 山本純也, 松谷英樹, 立川章太郎, 小川和彦, 小泉雅彦

日本癌学会総会記事, 80回 [J19-2], Sep, 2021
抗CTLA-4抗体併用下での放射線治療の線量増加による全身性抗腫瘍効果の増強について

武中渉, 高橋豊, 皆巳和賢, 玉利慶介, 立川章太郎, 勝木翔平, 山本純也, 松谷英樹, 小泉雅彦, 小川和彦

日本癌学会総会記事, 80回 [P12-1], Sep, 2021
p16-HNSCC患者の血漿中cell-free DNAを用いたdigital-PCRによるHPV-DNA検出

松谷英樹, 玉利慶介, 立川章太郎, 皆巳和賢, 高橋豊, 武中渉, 勝木翔平, 山本純也, 小川和彦, 小泉雅彦

日本癌学会総会記事, 80回 [P14-7], Sep, 2021
Alteration of tumor microenvironment and radioresistance induced by clonal hematopoiesis(和訳中)

立川章太郎, 元岡大祐, 玉利慶介, 皆巳和賢, 瀬尾雄二, 高橋豊, 今野雅允, 石井秀始, 猪原秀典, 小川和彦

日本血液学会学術集会, 83回 OS3-3, Sep, 2021
Local hyperthermia combined with CTLA-4 blockade induces both local and abscopal effects in a murine breast cancer model.

Yoriko Ibuki, Yutaka Takahashi, Keisuke Tamari, Kazumasa Minami, Yuji Seo, Fumiaki Isohashi, Masahiko Koizumi, Kazuhiko Ogawa

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 38(1) 363-371, 2021
【放射線治療の現状と将来】放射線治療と新規薬剤との併用

小川和彦, 高橋豊, 皆巳和賢, 玉利慶介, 礒橋文明

Medical Science Digest, 46(13) 796-799, Nov, 2020
【放射線治療の現状と将来】放射線治療と新規薬剤との併用

小川和彦, 高橋豊, 皆巳和賢, 玉利慶介, 礒橋文明

Medical Science Digest, 46(13) 796-799, Nov, 2020
乳癌に対するlocal hyperthermiaと抗CTLA-4抗体の併用による腫瘍内免疫微小環境の変化

伊吹依利子, 高橋豊, 玉利慶介, 皆巳和賢, 瀬尾雄二, 礒橋文明, 小泉雅彦, 小川和彦

Thermal Medicine, 36(Suppl.) OS3-5, Sep, 2020
Radiation Dose Escalation is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma.

Wataru Takenaka, Yutaka Takahashi, Keisuke Tamari, Kazumasa Minami, Shohei Katsuki, Yuji Seo, Fumiaki Isohashi, Masahiko Koizumi, Kazuhiko Ogawa

Cancers, 12(6), Jun 12, 2020 Peer-reviewed

Misc.

Radiation therapy enhances systemic antitumor efficacy in PD-L1 therapy regardless of sequence in murine osteosarcoma

Shohei Katsuki, Yutaka Takahashi, Keisuke Tamari, Kazumasa Minami, Wataru Takenaka, Junya Yamamoto, Hideki Matsutani, Shotaro Tatekawa, Kazuhiko Ogawa, Masahiko Koizumi

CANCER SCIENCE, 113, Feb, 2022
HPV-DNA detection by digital-PCR using cell-free DNA from plasma of p16-HNSCC patients

Hideki Matsutani, Keisuke Tamari, Shotaro Tatekawa, Kazumasa Minami, Yutaka Takahashi, Wataru Takenaka, Shohei Katsuki, Junya Yamamoto, Kazuhiko Ogawa, Masahiko Koizumi

CANCER SCIENCE, 113 1616-1616, Feb, 2022
Radiation at escalated dose enhances the systemic antitumor efficacy of anti-CTLA-4 antibody

Wataru Takenaka, Yutaka Takahashi, Kazumasa Minami, Keisuke Tamari, Shotaro Tatekawa, Shohei Katsuki, Junya Yamamoto, Hideki Matsutani, Masahiko Koizumi, Kazuhiko Ogawa

CANCER SCIENCE, 113 397-397, Feb, 2022
Combined effects of immunotherapy with anti-CTLA-4 antibody and radiation therapy on pancreatic ductal adeno carcinoma

Junya Yamamoto, Yutaka Takahashi, Kazumasa Minami, Keisuke Tamari, Shohei Katsuki, Wataru Takenaka, Hideki Matsutani, Shotaro Tatekawa, Kazuhiko Ogawa, Masahiko Koizumi

CANCER SCIENCE, 113 1427-1427, Feb, 2022
Optimization of combined therapy with carbon ion irradiation and immune checkpoint blockade

高橋豊, 勝木翔平, 伊吹依利子, 皆巳和賢, 中路拓, 下川卓志, 小川和彦, 小泉雅彦

量子科学技術研究開発機構研究報告書(Web), (20), 2021
Effects of radiation on the metastatic potential in cancer

55(3) 264-277, Sep, 2020
Optimization of combined therapy with carbon ion irradiation and immune checkpoint blockade

高橋豊, 勝木翔平, 伊吹依利子, 皆巳和賢, 中路拓, 小泉雅彦, 下川卓志, 小川和彦

量子科学技術研究開発機構研究報告書(Web), (17), 2020
免疫チェックポイント阻害剤とサイトカインを併用した腫瘍免疫療法における重粒子線の役割の解明

高橋豊, 伊吹依利子, 皆巳和賢, 中路拓, 小泉雅彦, 下川卓志, 小川和彦

量子科学技術研究開発機構研究報告書(Web), (13), 2019
重粒子線のがん転移能に与える影響

皆巳和賢, 沖裕也, 安井智洋, 佐野圭祐, 高橋豊, 玉利慶介, 大谷啓佑, 瀬尾雄二, 礒橋文明, 小泉雅彦 …

日本放射線影響学会大会抄録(Web), 60th 101, Oct 25, 2017
Ro90-7501 Is Identified As a Radiosensitizer By High Throughput Screening

K. Tamari, Y. Seo, Y. Takahashi, K. Otani, A. Kawashima, O. Suzuki, F. Isohashi, K. Ogawa

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 99(2) E619-E619, Oct, 2017
Radiation combined with checkpoint blockades enhanced antitumor efficacy for osteosarcoma

Yutaka Takahashi, Tomohiro Yasui, Keisuke Tamari, Kazumasa Minami, Masahiko Koizumi, Yuji Seo, Fumiaki Isohashi, Keisuke Ohtani, Ryosuke Kambe, Kazuhiko Ogawa

CANCER RESEARCH, 77, Jul, 2017
A concept for evaluation of time-variable dose-volume evaluating on the time-dose-volume manifold

ANETAI Yusuke, SUMIDA Iori, TAKAHASHI Yutaka, YAGI Masashi, MIZUNO Hirokazu, OGAWA Kazuhiko

医学物理 Supplement, 37(1), 2017
サイバーナイフを用いた前立腺癌IMRTにおける線量予測と位置精度の関係

水野裕一, 隅田伊織, 小池優平, 高橋豊, 八木雅史, 鈴木修, 塩見浩也, 吉岡靖生, 小川和彦

日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 29th, 2016
前立腺癌IMRTにおけるセットアップエラーを考慮した体内線量予測と放射線生物学的ガンマ評価

高津淳, 水野裕一, 金子暁里, 高橋豊, 八木雅史, 玉木伸幸, 吉岡靖生, 隅田伊織, 小川和彦

日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 29th, 2016
動体追尾照射に対する躍度最小モデルを用いた基準呼吸波の提案

姉帯優介, 隅田伊織, 高橋豊, 太田誠一, 八木雅史, 水野裕一, 鈴木修, 玉利慶介, 瀬尾雄二, 小川和彦

日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 29th, 2016
子宮頸癌に対する高線量率組織内照射

礒橋文明, 吉岡靖生, 小西浩司, 隅田伊織, 高橋豊, 尾方俊至, 小泉雅彦, 井上武宏, 馬淵誠士, 榎本隆之 …

日本婦人科腫瘍学会雑誌 = The journal of the Japan Society of Gynecologic Oncology, 29(2) 195-199, Apr 25, 2011
大阪大学病院におけるStep and Shoot IMRTの立ち上げ

高橋豊, 小泉雅彦, 隅田伊織, 尾方俊至, 秋野祐一, 井上武宏, 吉岡靖生, 礒橋文明, 小西浩司, 井ノ上信一 …

Japanese Journal of Radiology, 28(Suppl.I) 56-56, Jul, 2010
IMRT QAで検出されたコリメータ回転角度表示の不具合

秋野祐一, 隅田伊織, 高橋豊, 尾方俊至, 井上武宏, 吉岡靖生, 礒橋文明, 小西浩司, 小泉雅彦, 太田誠一 …

Japanese Journal of Radiology, 28(Suppl.I) 56-56, Jul, 2010
Feasibility Study For High-energy Radiotherapy Photon Beams using Radiochromic Film Postal Dosimetry Audit between Multi-institutions

I. Sumida, M. Koizumi, Y. Takahashi, T. Ogata, Y. Akino, K. Konishi, F. Isohashi, Y. Yoshioka, T. Inoue

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78(3) S842-S842, 2010
再発子宮頸癌に対する高線量率組織内照射

礒橋文明, 吉岡靖生, 小西浩司, 隅田伊織, 高橋豊, 尾方俊至, 小泉雅彦, 井上武宏

日本放射線腫よう学会誌, 21(Supplement 1), 2009

Books and Other Publications

放射線治療技術標準テキスト

奥村雅彦, 小口宏, 保品正夫, 高橋豊他 (Role: Joint author)

医学書院, Jan, 2019
Standard Dosimetry of Absorbed Dose to Water in Brachytherapy (Standard Dosimetry in Brachytherapy) 18

Kawamura S, Okamoto H, Kojima T, Takahashi Y, Takenaka T, Hanada T, Yamada T (Role: Joint author)

Apr, 2018
Radiotherapy physics

Endo M, Araki F, Takahashi Y (Role: Joint author)

Mar, 2016
Practice guide of medical radiation technology 3rd edition

(Role: Joint author)

Feb, 2014

Presentations

Translational Research and Radiation Biology

TAKAHASHI Yutaka

Hokkaido Summer Institute 2018 – Radiation Biology School-, Hokkaido, Aug 3, 2018 Invited

Research Projects

Local and Abscopal Effects of Heavy Ion Beam Irradiation in Combination with Immunotherapy for Radioresistant Tumors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
同所移植モデルによる難治性腫瘍免疫応答を誘導する免疫療法と放射線の併用戦略の検討

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

高橋豊, 武島嗣英, 西尾禎治, 小泉雅彦, 皆巳和賢
evelopment of immunoradiotherapy using ultra-high dose rate carbon ion beam irradiation for refractory cancer.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Basic study for the realization of intensity-modulated carbon-ion beam therapy.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
温熱、放射線、免疫チェックポイント阻害剤を組み合わせた新規な複合療法の開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2023

高橋豊, 小川和彦, 小泉雅彦
Development of new treatments for refractory cancer by combining radiation and immune checkpoint inhibitors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

OGAWA KAZUHIKO
Development of prediction of responder in cancer immunotherapy by using radiation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Takahashi Yutaka
Applicator with dosimeter for in vivo dose evaluation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Koizumi Masahiko, Kaneko Akari
Development of novel brachytherapy technique for various tumor sited that had never been treated

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2011

TAKAHASHI Yutaka
Construction of multidisciplinary improvement for radiation treatment machine between multi-institutions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

KOIZUMI Masahiko, SUMIDA Iori, TAKAHASHI Takahashi, AKINO Yuuichi
Improving accuracy of Iodine-125 permanent implant brachytherapy for prostate cancer based on real time in vivo dosimetry

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2007 - 2009

TAKAHASHI Yutaka
Research for irradiation reproducibility of interstitial brachytherapy using in vivo dosietry

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2008

NOSE Takayuki, ITO Akira, KOZUKA Takuyo, SUMIDA Iori, TAKAHASHI Yutaka, YAMASHITA Takashi
前立腺癌に対する外部照射併用I-125永久挿入治療の外部照射治療計画の高精度化

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2005 - 2006

高橋豊
Standard dosimetry of I-125 seeds against prostate cancer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

ITO Akira, TAKAHASHI Yutaka, HINO Yoshiho
The study on the planning of the future radiation therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

YAMASHITA Takashi, HIROKAWA Yutaka, OGUCHI Masahiko, ONISHI Hiroshi, TAKAHASHI Yutaka

Profile Information

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Misc.

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