2012年5月
Rewiring of Afferent Fibers in the Somatosensory Thalamus of Mice Caused by Peripheral Sensory Nerve Transection
JOURNAL OF NEUROSCIENCE
- ,
- ,
- ,
- ,
- ,
- 巻
- 32
- 号
- 20
- 開始ページ
- 6917
- 終了ページ
- 6930
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1523/JNEUROSCI.5008-11.2012
- 出版者・発行元
- SOC NEUROSCIENCE
The remodeling of neural circuitry and changes in synaptic efficacy after peripheral sensory nerve injury are considered the basis for functional reorganization in the brain, including changes in receptive fields. However, when or how the remodeling occurs is largely unknown. Here we show the rapid rewiring of afferent fibers in the mature ventral posteromedial thalamic nucleus of mice after transection of the peripheral whisker sensory nerve, using the whole-cell voltage-clamp technique. Transection induced the recruitment of afferent fibers to a thalamic relay neuron within 5-6 d of injury. The rewiring was pathway specific, but not sensory experience dependent or peripheral nerve activity dependent. The newly recruited fibers mediated small EPSCs, and postsynaptic GluA2-containing AMPA receptors were selectively upregulated at the new synapses. This rapid and pathway-specific remodeling of thalamic circuitry may be an initial step in the massive axonal reorganization at supraspinal levels, which occurs months or years after peripheral sensory nerve injury.
- リンク情報
- ID情報
-
- DOI : 10.1523/JNEUROSCI.5008-11.2012
- ISSN : 0270-6474
- PubMed ID : 22593060
- Web of Science ID : WOS:000304419700017