2018年2月
Current characteristics of hemophilia patients co-infected with HIV/HCV in Japan.
Experimental and therapeutic medicine
- 巻
- 15
- 号
- 2
- 開始ページ
- 2148
- 終了ページ
- 2155
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3892/etm.2017.5603
Over 30 years have passed since co-infection with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) was first documented in hemophilia patients in Japan. In such cases, the leading cause of mortality is reportedly HCV-associated end-stage liver disease. However, the current characteristics of hemophilia patients co-infected with HIV/HCV are unknown. The aim of the present study was to reveal the current characteristics, notably HCV geno-prevalence and liver function, among hemophilia patients co-infected with HIV/HCV in Japan. Current characteristics were evaluated using cross-sectional retrospective data of 44 hemophilia patients positive for anti-HCV and anti-HIV antibodies who underwent screening of liver dysfunction. A total of 56.8% of hemophilia patients co-infected with HIV/HCV were positive for HCV RNA. The most common HCV genotypes were 1a, 1b and 3a. Liver cirrhosis was diagnosed in 26.3% patients negative for HCV RNA and 60.0% patients positive for HCV RNA. Decompensated liver cirrhosis was diagnosed in 33.3% HCV RNA-positive patients and none of the HCV RNA-negative patients. The rate of liver cirrhosis was greater for HCV genotype 3a compared with other genotypes. Overall, the current primary HCV RNA genotypes among hemophilia patients co-infected with HIV/HCV are 1a, 1b and 3a. Over 50% of HIV/HCV co-infected hemophilia patients positive for HCV RNA were diagnosed with liver cirrhosis and some were diagnosed with decompensated liver cirrhosis.
- リンク情報
-
- DOI
- https://doi.org/10.3892/etm.2017.5603
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29434818
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776657
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000423221600139&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.3892/etm.2017.5603
- ISSN : 1792-0981
- PubMed ID : 29434818
- PubMed Central 記事ID : PMC5776657
- Web of Science ID : WOS:000423221600139