論文

査読有り
2017年12月

Bundle Gel Fibers with a Tunable Microenvironment for in Vitro Neuron Cell Guiding

ACS APPLIED MATERIALS & INTERFACES
  • Sayaka Tachizawa
  • ,
  • Haruko Takahashi
  • ,
  • Young-Jin Kim
  • ,
  • Aoi Odawara
  • ,
  • Joris Pauty
  • ,
  • Yoshiho Ikeuchi
  • ,
  • Ikuro Suzuki
  • ,
  • Akihiko Kikuchi
  • ,
  • Yukiko T. Matsunaga

9
49
開始ページ
43250
終了ページ
43257
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/acsami.7b14585
出版者・発行元
AMER CHEMICAL SOC

As scaffolds for neuron cell guiding in vitro, gel fibers with a bundle structure, comprising multiple microfibrils, were fabricated using a microfluidic device system by casting a phase-separating polymer blend solution comprising hydroxypropyl cellulose (HPC) and sodium alginate (Na-Alg). The topology and stiffness of the obtained bundle gel fibers depended on their microstructure derived by the polymer blend ratio of HPC and Na-Alg. High concentrations of Na-Alg led to the formation of small microfibrils in a one-bundle gel fiber and stiff characteristics. These bundle gel fibers permitted for the elongation of the neuron cells along their axon orientation with the long axis of fibers. In addition, human-induced pluripotent-stem-cell-derived dopaminergic neuron progenitor cells were differentiated into neuronal cells gels. The bundle gel fibers demonstrated an enormous potential as cell culture scaffold materials with an optimal microenvironment for guiding neuron cells.

リンク情報
DOI
https://doi.org/10.1021/acsami.7b14585
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29086563
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000418204300092&DestApp=WOS_CPL
共同研究・競争的資金等の研究課題
ボトムアップ組織形成術による生体組織システムの構築
ID情報
  • DOI : 10.1021/acsami.7b14585
  • ISSN : 1944-8244
  • PubMed ID : 29086563
  • Web of Science ID : WOS:000418204300092

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