2017年12月
Bundle Gel Fibers with a Tunable Microenvironment for in Vitro Neuron Cell Guiding
ACS APPLIED MATERIALS & INTERFACES
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- 巻
- 9
- 号
- 49
- 開始ページ
- 43250
- 終了ページ
- 43257
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acsami.7b14585
- 出版者・発行元
- AMER CHEMICAL SOC
As scaffolds for neuron cell guiding in vitro, gel fibers with a bundle structure, comprising multiple microfibrils, were fabricated using a microfluidic device system by casting a phase-separating polymer blend solution comprising hydroxypropyl cellulose (HPC) and sodium alginate (Na-Alg). The topology and stiffness of the obtained bundle gel fibers depended on their microstructure derived by the polymer blend ratio of HPC and Na-Alg. High concentrations of Na-Alg led to the formation of small microfibrils in a one-bundle gel fiber and stiff characteristics. These bundle gel fibers permitted for the elongation of the neuron cells along their axon orientation with the long axis of fibers. In addition, human-induced pluripotent-stem-cell-derived dopaminergic neuron progenitor cells were differentiated into neuronal cells gels. The bundle gel fibers demonstrated an enormous potential as cell culture scaffold materials with an optimal microenvironment for guiding neuron cells.
- リンク情報
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- DOI
- https://doi.org/10.1021/acsami.7b14585
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29086563
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000418204300092&DestApp=WOS_CPL
- 共同研究・競争的資金等の研究課題
- ボトムアップ組織形成術による生体組織システムの構築
- ID情報
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- DOI : 10.1021/acsami.7b14585
- ISSN : 1944-8244
- PubMed ID : 29086563
- Web of Science ID : WOS:000418204300092