論文

査読有り
2016年

Bio-inspired smart hydrogel with temperature-dependent properties and enhanced cell attachment

JOURNAL OF MATERIALS CHEMISTRY B
  • Young-Jin Kim
  • ,
  • Misa Tachibana
  • ,
  • Mitsuo Umezu
  • ,
  • Yukiko T. Matsunaga

4
9
開始ページ
1740
終了ページ
1746
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1039/c5tb02735g
出版者・発行元
ROYAL SOC CHEMISTRY

Stimuli-responsive smart hydrogels have been exploited for various applications, including as biomaterials with environment-dependent changes in hydrophobicity, stiffness or volume. In this study, we report the functionalisation of a temperature-responsive poly(N-isopropylacryamide) (PNIPAAm) smart hydrogel with catechol groups to enhance its stiffness and cell attachment. To introduce biomimetic adhesive catechol group, which is derived from mussel feet, a photo-crosslinkable 3-hydroxytyramine hydrochloride-derived dopamine methacrylamide (DMA) monomer was synthesised. Then, temperature-responsive smart copolymer hydrogels were successfully fabricated by photo-polymerisation of the DMA with N-isopropyl-acryamide (NIPAAm). The fabricated smart hydrogels demonstrated temperature-dependent properties, and the DMA affected the swelling behaviour and compressive mechanical strength. In vitro cell culture experiments showed that the catechol groups in the smart hydrogels promoted cell attachment and spreading. These smart hydrogels will be useful as biomaterials as tissue scaffolds with controllable properties.

リンク情報
DOI
https://doi.org/10.1039/c5tb02735g
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000371062000018&DestApp=WOS_CPL
共同研究・競争的資金等の研究課題
ボトムアップ組織形成術による生体組織システムの構築
URL
http://orcid.org/0000-0002-0483-9423
ID情報
  • DOI : 10.1039/c5tb02735g
  • ISSN : 2050-750X
  • eISSN : 2050-7518
  • ORCIDのPut Code : 38310129
  • Web of Science ID : WOS:000371062000018

エクスポート
BibTeX RIS