2018年7月19日
Enzymatic one-step ring contraction for quinolone biosynthesis.
Nature communications
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- 巻
- 9
- 号
- 1
- 開始ページ
- 2826
- 終了ページ
- 2826
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41467-018-05221-5
The 6,6-quinolone scaffolds on which viridicatin-type fungal alkaloids are built are frequently found in metabolites that display useful biological activities. Here we report in vitro and computational analyses leading to the discovery of a hemocyanin-like protein AsqI from the Aspergillus nidulans aspoquinolone biosynthetic pathway that forms viridicatins via a conversion of the cyclopenin-type 6,7-bicyclic system into the viridicatin-type 6,6-bicyclic core through elimination of carbon dioxide and methylamine through methyl isocyanate.
- リンク情報
- ID情報
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- DOI : 10.1038/s41467-018-05221-5
- PubMed ID : 30026518
- PubMed Central 記事ID : PMC6053404