Yuichiro Hara - My portal

Profile Information

Affiliation: Chief Researcher, Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science

Degree: 博士(学術)(総合研究大学院大学)

J-GLOBAL ID: 201801006074917840
researchmap Member ID: B000330681

External link: https://sites.google.com/view/yuichirohara/home

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Kitasato University
Jul, 2020 - Present

Chief Researcher, Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science
Oct, 2018 - Mar, 2022

客員研究員, 生命機能科学研究センター, 理化学研究所
Apr, 2019 - Jun, 2020

Research Institute of Environmental Medicine, Nagoya University
Oct, 2018 - Mar, 2020

Graduate School of Science, The University of Tokyo
Oct, 2018 - Mar, 2019

Research Institute of Environmental Medicine, Nagoya University
Apr, 2016 - Oct, 2018

基礎科学特別研究員, ライフサイエンス基盤技術研究センター (2018/4より生命機能科学研究センター), 理化学研究所
Apr, 2013 - Mar, 2016

研究員, 発生・再生科学総合研究センター（2014/11よりライフサイエンス基盤技術研究センター）, 理化学研究所

Papers

PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke

Akari Nakamura, Seiichiro Sakai, Yoshitaka Taketomi, Jun Tsuyama, Yoshimi Miki, Yuichiro Hara, Nobutaka Arai, Yuki Sugiura, Hideya Kawaji, Makoto Murakami …

Neuron, 111(19) 2995-3010.e9, Oct, 2023
The impact of local genomic properties on the evolutionary fate of genes.

Yuichiro Hara, Shigehiro Kuraku

eLife, 12, May 24, 2023
Spatial transcriptome of developmental mouse brain reveals temporal dynamics of gene expressions and heterogeneity of the claustrum

Yuichiro Hara, Takuma Kumamoto, Naoko Yoshizawa-Sugata, Kumiko Hirai, Song Xianghe, Hideya Kawaji, Chiaki Ohtaka-Maruyama

Apr 13, 2023
Transcriptomic exploration of the Coleopteran wings reveals insight into the evolution of novel structures associated with the beetle elytron.

David M Linz, Yuichiro Hara, Kevin D Deem, Shigehiro Kuraku, Shigeo Hayashi, Yoshinori Tomoyasu

Journal of experimental zoology. Part B, Molecular and developmental evolution, 340(2) 197-213, Mar, 2023
Inference of a genome-wide protein-coding gene set of the inshore hagfish Eptatretus burgeri

Osamu Nishimura, Kazuaki Yamaguchi, Yuichiro Hara, Kaori Tatsumi, Jeramiah J Smith, Mitsutaka Kadota, Shigehiro Kuraku

F1000Research, 11 1270-1270, Nov 8, 2022
Metabolome and transcriptome analysis on muscle of sporadic inclusion body myositis

Ayuka Murakami, Seiya Noda, Tomoyuki Kazuta, Satoko Hirano, Seigo Kimura, Hirotaka Nakanishi, Koji Matsuo, Koyo Tsujikawa, Madoka Iida, Haruki Koike …

Annals of Clinical and Translational Neurology, 9(10) 1602-1615, Sep 15, 2022
The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice

Naoya Yamaguchi, Atsushi Suzuki, Aya Yoshida, Tatsushi Tanaka, Kohei Aoyama, Hisashi Oishi, Yuichiro Hara, Tomoo Ogi, Izuki Amano, Satomi Kameo …

Scientific Reports, 12(1), Jul 4, 2022
Ten Years of Collaborative Progress in the Quest for Orthologs.

Benjamin Linard, Ingo Ebersberger, Shawn E McGlynn, Natasha Glover, Tomohiro Mochizuki, Mateus Patricio, Odile Lecompte, Yannis Nevers, QFO Consortium, Paul D Thomas …

Molecular biology and evolution, 38(8) 3033-3045, Jul 29, 2021 Peer-reviewed
Parallel evolution of trehalose production machinery in anhydrobiotic animals via recurrent gene loss and horizontal transfer.

Yuichiro Hara, Reira Shibahara, Koyuki Kondo, Wataru Abe, Takekazu Kunieda

Open biology, 11(7) 200413-200413, Jul, 2021 Peer-reviewed
ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.

Yana van der Weegen, Klaas de Lint, Diana van den Heuvel, Yuka Nakazawa, Tycho E T Mevissen, Janne J M van Schie, Marta San Martin Alonso, Daphne E C Boer, Román González-Prieto, Ishwarya V Narayanan …

Nature cell biology, 23(6) 595-607, Jun, 2021 Peer-reviewed
Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.

Akira Sobue, Okiru Komine, Yuichiro Hara, Fumito Endo, Hiroyuki Mizoguchi, Seiji Watanabe, Shigeo Murayama, Takashi Saito, Takaomi C Saido, Naruhiko Sahara …

Acta neuropathologica communications, 9(1) 1-1, Jan 5, 2021 Peer-reviewed
Expanding the phenotype of biallelic loss-of-function variants in the NSUN2 gene: Description of four individuals with juvenile cataract, chronic nephritis, or brain anomaly as novel complications.

Kohji Kato, Seiji Mizuno, Jenny Morton, Miho Toyama, Yuichiro Hara, Evangeline Wasmer, Alan Lehmann, Tomoo Ogi

American journal of medical genetics. Part A, 185(1) 282-285, Jan, 2021 Peer-reviewed
Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.

Yasuyoshi Oka, Motoharu Hamada, Yuka Nakazawa, Hideki Muramatsu, Yusuke Okuno, Koichiro Higasa, Mayuko Shimada, Honoka Takeshima, Katsuhiro Hanada, Taichi Hirano …

Science advances, 6(51), Dec, 2020 Peer-reviewed
Early vertebrate origin of CTCFL, a CTCF paralog, revealed by proximity-guided shark genome scaffolding

Mitsutaka Kadota, Kazuaki Yamaguchi, Yuichiro Hara, Shigehiro Kuraku

Scientific Reports, 10(1), Dec, 2020 Peer-reviewed
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.

Hiroyuki Konishi, Takayuki Okamoto, Yuichiro Hara, Okiru Komine, Hiromi Tamada, Mitsuyo Maeda, Fumika Osako, Masaaki Kobayashi, Akira Nishiyama, Yosky Kataoka …

The EMBO journal, 39(22) e104464, Nov 16, 2020 Peer-reviewed
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.

Yuka Nakazawa, Yuichiro Hara, Yasuyoshi Oka, Okiru Komine, Diana van den Heuvel, Chaowan Guo, Yasukazu Daigaku, Mayu Isono, Yuxi He, Mayuko Shimada …

Cell, Feb 26, 2020 Peer-reviewed
Nodal paralogues underlie distinct mechanisms for visceral left-right asymmetry in reptiles and mammals.

Eriko Kajikawa, Uzuki Horo, Takahiro Ide, Katsutoshi Mizuno, Katsura Minegishi, Yuichiro Hara, Yayoi Ikawa, Hiromi Nishimura, Masanori Uchikawa, Hiroshi Kiyonari …

Nature ecology & evolution, 4(2) 261-269, Feb, 2020 Peer-reviewed
Comprehensive analysis of genes contributing to euryhalinity in the bull shark, Carcharhinus leucas; Na+-Cl- co-transporter is one of the key renal factors upregulated in acclimation to low-salinity environment.

Itaru Imaseki, Midori Wakabayashi, Yuichiro Hara, Taro Watanabe, Souichirou Takabe, Keigo Kakumura, Yuki Honda, Keiichi Ueda, Kiyomi Murakumo, Rui Matsumoto …

The Journal of experimental biology, 222(Pt 12), Jun 27, 2019 Peer-reviewed
Evaluating Genome Assemblies and Gene Models Using gVolante.

Osamu Nishimura, Yuichiro Hara, Shigehiro Kuraku

Methods in molecular biology (Clifton, N.J.), 1962 247-256, 2019 Peer-reviewedInvited
Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates.

Yuichiro Hara, Kazuaki Yamaguchi, Koh Onimaru, Mitsutaka Kadota, Mitsumasa Koyanagi, Sean D Keeley, Kaori Tatsumi, Kaori Tanaka, Fumio Motone, Yuka Kageyama …

Nature ecology & evolution, 2(11) 1761-1771, Nov, 2018 Peer-reviewed

Misc.

オミクス解析にも応える実験動物ソメワケササクレヤモリ—ニワトリに代わる哺乳類の比較対象として (私の実験動物、やっぱり個性派です連載第5回)

原雄一郎, 清成寛, 工樂樹洋

実験医学, 36(9) 1540-1544, Jun, 2018 Invited
どのアセンブリを使うか?: 分子系統学的観点に基づくアセンブリの評価

原雄一郎

日本進化学会ニュース, 17(1) 23-29, Mar, 2016 Invited
脊椎動物ゲノム・トランスクリプトームアセンブリ完全度を評価する

原雄一郎

バイオサイエンスとインダストリー, 74(3) 228-230, 2016 Invited

Professional Memberships

Research Projects

Elucidation of de novo gene birth and pseudogenization processes via reconstruction of ancestral transcriptional regulation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
慢性炎症性疾患の免疫細胞における脂質リプログラミングの意義の解明

科学研究費助成事業, 国際共同研究加速基金(国際共同研究強化(B)), 日本学術振興会, Oct, 2019 - Mar, 2023

伊藤綾香, 菅波孝祥, 原雄一郎
Evolutionary genomics of ultramicro inversions.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

IMANISHI Tadashi, HARA Yuichiro