Jun 1, 2018
Aquaporin Positron Emission Tomography Differentiates Between Grade III and IV Human Astrocytoma
Neurosurgery
- Volume
- 82
- Number
- 6
- First page
- 842
- Last page
- 846
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1093/neuros/nyx314
- Publisher
- Oxford University Press (OUP)
<title>Abstract</title>
<sec>
<title>BACKGROUND</title>
Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade.
</sec>
<sec>
<title>OBJECTIVE</title>
To examine the utility of aquaporin positron emission tomography (PET) for differentiating between astrocytoma grade III and grade IV using the AQP radioligand [11C]TGN-020.
</sec>
<sec>
<title>METHODS</title>
Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10 healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues of astrocytoma patients were examined for histopathological grading using the WHO classification standard and expression of AQP1 and AQP4 immunohistochemically.
</sec>
<sec>
<title>RESULTS</title>
Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs 1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P &lt; .001) for both tumor grades. Importantly, mean standardized uptake values of astrocytoma grade IV were significantly higher than grade III (P &lt; .01).
</sec>
<sec>
<title>CONCLUSION</title>
Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as a noninvasive diagnostic tool would lead to advancements in the management of these malignant brain tumors.
</sec>
<sec>
<title>BACKGROUND</title>
Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade.
</sec>
<sec>
<title>OBJECTIVE</title>
To examine the utility of aquaporin positron emission tomography (PET) for differentiating between astrocytoma grade III and grade IV using the AQP radioligand [11C]TGN-020.
</sec>
<sec>
<title>METHODS</title>
Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10 healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues of astrocytoma patients were examined for histopathological grading using the WHO classification standard and expression of AQP1 and AQP4 immunohistochemically.
</sec>
<sec>
<title>RESULTS</title>
Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs 1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P &lt; .001) for both tumor grades. Importantly, mean standardized uptake values of astrocytoma grade IV were significantly higher than grade III (P &lt; .01).
</sec>
<sec>
<title>CONCLUSION</title>
Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as a noninvasive diagnostic tool would lead to advancements in the management of these malignant brain tumors.
</sec>
- Link information
- ID information
-
- DOI : 10.1093/neuros/nyx314
- ISSN : 0148-396X
- eISSN : 1524-4040
- Pubmed ID : 28645205
- Pubmed Central ID : PMC5952963