2019年
Molecular Dynamics Simulations of Condensin-Mediated Mitotic Chromosome Assembly
Methods in Molecular Biology
- ,
- ,
- 巻
- 2004
- 号
- 開始ページ
- 319
- 終了ページ
- 334
- 記述言語
- 英語
- 掲載種別
- 論文集(書籍)内論文
- DOI
- 10.1007/978-1-4939-9520-2_22
- 出版者・発行元
- Springer New York
Molecular dynamics simulation is a powerful tool used in modern molecular modeling, which enables a deeper comprehension of the physical behavior of atoms and molecules at a micro level. In this study, we simulated mitotic chromosome assembly mediated by condensins, a class of large protein complexes containing a pair of structural maintenance of chromosomes (SMC) subunits that are central to this process. In this chapter, we present the construction of a coarse-grained physical model of chromosomal DNA fibers and condensin molecules, and monitoring of the function of condensins in mitotic chromosome assembly, using computer-based molecular dynamics simulation. We explain how our model of chromosomes and condensins may be simulated using a package of molecular dynamics simulation. Procedures involved in calculating the observables of dynamics are described, together with an example of the simulation results.
- リンク情報
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- DOI
- https://doi.org/10.1007/978-1-4939-9520-2_22
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/31147926
- URL
- http://link.springer.com/content/pdf/10.1007/978-1-4939-9520-2_22
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066796432&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85066796432&origin=inward
- ID情報
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- DOI : 10.1007/978-1-4939-9520-2_22
- ISSN : 1064-3745
- eISSN : 1940-6029
- ORCIDのPut Code : 67378634
- PubMed ID : 31147926
- SCOPUS ID : 85066796432