2013年
Novel mouse models of hepatocarcinogenesis with stepwise accumulation of genetic alterations.
Digestive diseases (Basel, Switzerland)
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- 巻
- 31
- 号
- 5-6
- 開始ページ
- 454
- 終了ページ
- 8
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1159/000355244
- 出版者・発行元
- KARGER
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Various risk factors are involved in hepatocarcinogenesis. Among them, chronic inflammation, including chronic hepatitis and cirrhosis mainly caused by hepatitis B virus and/or hepatitis C virus infection, plays an important role in HCC development. On the other hand, comprehensive genetic analyses of HCC using whole genome and exome sequencing revealed that cancer cells possess a large number of somatic mutations, suggesting that a wide variety of genetic alterations and the resultant dysregulated molecular pathways contribute to the development of HCC. Activation-induced cytidine deaminase (AID) is a nucleotide-editing enzyme, and aberrant expression of AID induced by inflammatory responses contributes to hepatocarcinogenesis via the accumulation of genetic alterations in various tumor-related genes. Constitutive expression of AID in hepatocyte-lineage cells provides novel mouse models that recapitulate the tumorigenesis of human HCC through stepwise accumulation of genetic alterations.
- リンク情報
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- DOI
- https://doi.org/10.1159/000355244
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/24281020
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000327581700009&DestApp=WOS_CPL
- URL
- http://orcid.org/0000-0003-4426-1491
- ID情報
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- DOI : 10.1159/000355244
- ISSN : 0257-2753
- eISSN : 1421-9875
- ORCIDのPut Code : 25194226
- PubMed ID : 24281020
- Web of Science ID : WOS:000327581700009