2016年3月
Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons
CELL AND TISSUE RESEARCH
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- 巻
- 363
- 号
- 3
- 開始ページ
- 621
- 終了ページ
- 633
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00441-015-2283-8
- 出版者・発行元
- SPRINGER
Activating transcription factor 5 (ATF5) is a member of the CREB/ATF family of transcription factors, which is highly expressed in olfactory chemosensory tissues, the main olfactory epithelium and vomeronasal epithelium (VNE) in mice. The vomeronasal sensory neurons in the VNE detect pheromones in order to regulate social behaviors such as mating and aggression; however, the physiological role of ATF5 in the vomeronasal sensory system remains unknown. In this study, we found that the differentiation of mature vomeronasal sensory neurons, assessed by olfactory marker protein expression, was inhibited in ATF5-deficient VNE. In addition, many apoptotic vomeronasal sensory neurons were evident in ATF5-deficient VNE. The vomeronasal sensory neurons consist of two major types of neuron expressing either vomeronasal 1 receptor (V1r)/G alpha i2 or vomeronasal 2 receptor (V2r)/G alpha o. We demonstrated that the differentiation, survival and axonal projection of V2r/G alpha o-type rather than V1r/G alpha i2-type vomeronasal sensory neurons were severely inhibited in ATF5-deficient VNE. These results suggest that ATF5 is one of the transcription factors crucial for the vomeronasal sensory formation.
- リンク情報
- ID情報
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- DOI : 10.1007/s00441-015-2283-8
- ISSN : 0302-766X
- eISSN : 1432-0878
- Web of Science ID : WOS:000370954400004